A novel small molecule, LLL12, inhibits STAT3 phosphorylation and activities and exhibits potent growth-suppressive activity in human cancer cells. - Wikidata - wikimedia - TriplyDB

A novel small molecule, LLL12, inhibits STAT3 phosphorylation and activities and exhibits potent growth-suppressive activity in human cancer cells.

A novel small molecule, LLL12, inhibits STAT3 phosphorylation and activities and exhibits potent growth-suppressive activity in human cancer cells.

http://www.wikidata.org/entity/Q30492764

about

Dinosaurs and ancient civilizations: reflections on the treatment of cancer Targeted inhibition of STATs and IRFs as a potential treatment strategy in cardiovascular disease Cancer microenvironment, inflammation and cancer stem cells: A hypothesis for a paradigm change and new targets in cancer control Split green fluorescent protein as a modular binding partner for protein crystallization CYP3A4 mediates growth of estrogen receptor-positive breast cancer cells in part by inducing nuclear translocation of phospho-Stat3 through biosynthesis of (±)-14,15-epoxyeicosatrienoic acid (EET)Identification of STAT1 and STAT3 specific inhibitors using comparative virtual screening and docking validation Ultrasound mediated delivery of oxygen and LLL12 loaded stimuli responsive microdroplets for the treatment of hypoxic cancer cells.Discovery of monocarbonyl curcumin-BTP hybrids as STAT3 inhibitors for drug-sensitive and drug-resistant breast cancer therapy.Endogenously Expressed IL-4Rα Promotes the Malignant Phenotype of Human Pancreatic Cancer In Vitro and In Vivo.STAT inhibitors for cancer therapy.The nontoxic natural compound Curcumin exerts anti-proliferative, anti-migratory, and anti-invasive properties against malignant gliomas.Development, characterization, and reversal of acquired resistance to the MEK1 inhibitor selumetinib (AZD6244) in an in vivo model of childhood astrocytoma.The small molecule, LLL12, inhibits STAT3 phosphorylation and induces apoptosis in medulloblastoma and glioblastoma cells.STAT3 serine 727 phosphorylation influences clinical outcome in glioblastoma.The small molecule curcumin analog FLLL32 induces apoptosis in melanoma cells via STAT3 inhibition and retains the cellular response to cytokines with anti-tumor activity Inhibition of STAT3 signaling blocks the anti-apoptotic activity of IL-6 in human liver cancer cells.Anti-angiogenic activity of a small molecule STAT3 inhibitor LLL12.Calpain/SHP-1 interaction by honokiol dampening peritoneal dissemination of gastric cancer in nu/nu mice STAT3 expression, molecular features, inflammation patterns, and prognosis in a database of 724 colorectal cancers STAT3 activation promotes oncolytic HSV1 replication in glioma cells.STAT3 is necessary for proliferation and survival in colon cancer-initiating cells.Stat3 signaling in acute myeloid leukemia: ligand-dependent and -independent activation and induction of apoptosis by a novel small-molecule Stat3 inhibitor.Evaluation of STAT3 signaling in ALDH+ and ALDH+/CD44+/CD24- subpopulations of breast cancer cells.Glioma cell migration on three-dimensional nanofiber scaffolds is regulated by substrate topography and abolished by inhibition of STAT3 signaling.Antagonism of the Stat3-Stat3 protein dimer with salicylic acid based small molecules.STAT3 upregulation in pituitary somatotroph adenomas induces growth hormone hypersecretion.A small molecule, LLL12 inhibits constitutive STAT3 and IL-6-induced STAT3 signaling and exhibits potent growth suppressive activity in human multiple myeloma cells.The interconnectedness of cancer cell signaling.Characterization of STAT3 expression, signaling and inhibition in feline oral squamous cell carcinoma Hirsutinolide Series Inhibit Stat3 Activity, Alter GCN1, MAP1B, Hsp105, G6PD, Vimentin, TrxR1, and Importin α-2 Expression, and Induce Antitumor Effects against Human Glioma.LLL12, a novel small inhibitor targeting STAT3 for hepatocellular carcinoma therapy.Salinomycin Promotes Anoikis and Decreases the CD44+/CD24- Stem-Like Population via Inhibition of STAT3 Activation in MDA-MB-231 Cells Rational combination of MEK inhibitor and the STAT3 pathway modulator for the therapy in K-Ras mutated pancreatic and colon cancer cells.Targeting of Rac GTPases blocks the spread of intact human breast cancer.Hydroxamic Acid and Benzoic Acid-Based STAT3 Inhibitors Suppress Human Glioma and Breast Cancer Phenotypes In Vitro and In Vivo.Erdr1 Suppresses Murine Melanoma Growth via Regulation of Apoptosis.A novel small molecule STAT3 inhibitor, LY5, inhibits cell viability, colony formation, and migration of colon and liver cancer cells.STAT3 as a potential therapeutic target in ALDH+ and CD44+/CD24+ stem cell-like pancreatic cancer cells Signal transducer and activator of transcription 3 (STAT3): a promising target for anticancer therapy.Novel inhibitors of signal transducer and activator of transcription 3 signaling pathway: an update on the recent patent literature.

P2860

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P2860

A novel small molecule, LLL12, inhibits STAT3 phosphorylation and activities and exhibits potent growth-suppressive activity in human cancer cells.

http://www.wikidata.org/entity/Q30492764

description

2010 nî lūn-bûn

@nan

2010 թուականի Յունուարին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի հունվարին հրատարակված գիտական հոդված

@hy

2010年の論文

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2010年論文

@yue

2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

name

A novel small molecule, LLL12, ...... ctivity in human cancer cells.

@ast

A novel small molecule, LLL12, ...... ctivity in human cancer cells.

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type

label

A novel small molecule, LLL12, ...... ctivity in human cancer cells.

@ast

A novel small molecule, LLL12, ...... ctivity in human cancer cells.

@en

prefLabel

A novel small molecule, LLL12, ...... ctivity in human cancer cells.

@ast

A novel small molecule, LLL12, ...... ctivity in human cancer cells.

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P2860

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A novel small molecule, LLL12, ...... ctivity in human cancer cells.

@en

P2093

Brian Hutzen

http://www.w3.org/2001/XMLSchema#string

Chenglong Li

http://www.w3.org/2001/XMLSchema#string

Deepak Bhasin

http://www.w3.org/2001/XMLSchema#string

Elizabeth Foust

http://www.w3.org/2001/XMLSchema#string

Jiayuh Lin

http://www.w3.org/2001/XMLSchema#string

Lauren Friedman

http://www.w3.org/2001/XMLSchema#string

Li Lin

http://www.w3.org/2001/XMLSchema#string

Ling Cen

http://www.w3.org/2001/XMLSchema#string

Matthew Sobo

http://www.w3.org/2001/XMLSchema#string

Mingxin Zuo

http://www.w3.org/2001/XMLSchema#string

P2860

The Hallmarks of Cancer

Stable expression of constitutively-activated STAT3 in benign prostatic epithelial cells changes their phenotype to that resembling malignant cells

Signal transducer and activator of transcription 3 (STAT3) activation in prostate cancer: Direct STAT3 inhibition induces apoptosis in prostate cancer lines.

Cancer statistics, 2008

Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma

New and old functions of STAT3: a pivotal target for individualized treatment of cancer

Dominant negative stat3 mutant inhibits interleukin-6-induced Jak-STAT signal transduction

The experimental use of antisense oligonucleotides: a guide for the perplexed

Phosphotyrosyl peptides block Stat3-mediated DNA binding activity, gene regulation, and cell transformation

Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors

P304

39-50

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scholarly article

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10.1593/NEO.91196

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P433

1

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P478

12

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2010-01-01T00:00:00Z

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41013927

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20072652

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P921

phosphorylation

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2805882

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