Targeting of Rac GTPases blocks the spread of intact human breast cancer.
about
Computer-based identification of a novel LIMK1/2 inhibitor that synergizes with salirasib to destabilize the actin cytoskeletonPLEKHG2 promotes heterotrimeric G protein βγ-stimulated lymphocyte migration via Rac and Cdc42 activation and actin polymerization.Dynamic interplay between adhesion surfaces in carcinomas: Cell-cell and cell-matrix crosstalkModulation of actin dynamics by Rac1 to target cognitive functionmTOR Directs Breast Morphogenesis through the PKC-alpha-Rac1 Signaling AxisQuantification of dynamic morphological drug responses in 3D organotypic cell cultures by automated image analysisPreclinical development of novel Rac1-GEF signaling inhibitors using a rational design approach in highly aggressive breast cancer cell lines.Interplay of PKA and Rac: fine-tuning of Rac localization and signaling.Therapeutic sensitivity to Rac GTPase inhibition requires consequential suppression of mTORC1, AKT, and MEK signaling in breast cancerRac1 as a potential therapeutic target for chemo-radioresistant head and neck squamous cell carcinomas (HNSCC)Two distinct mTORC2-dependent pathways converge on Rac1 to drive breast cancer metastasis.Deregulation of the EGFR/PI3K/PTEN/Akt/mTORC1 pathway in breast cancer: possibilities for therapeutic intervention.MicroRNA-200b targets protein kinase Cα and suppresses triple-negative breast cancer metastasisThe Rac Inhibitor EHop-016 Inhibits Mammary Tumor Growth and Metastasis in a Nude Mouse Model.Subtype-specific overexpression of the Rac-GEF P-REX1 in breast cancer is associated with promoter hypomethylation.Proteomics of cancer stem cells.EHT 1864, a small molecule inhibitor of Ras-related C3 botulinum toxin substrate 1 (Rac1), attenuates glucose-stimulated insulin secretion in pancreatic β-cells.CD147 promotes Src-dependent activation of Rac1 signaling through STAT3/DOCK8 during the motility of hepatocellular carcinoma cells.Characterising the tumour morphological response to therapeutic intervention: an ex vivo model.Two Rac paralogs regulate polarized growth in the human fungal pathogen Cryptococcus neoformansResearch resource: progesterone receptor targetome underlying mammary gland branching morphogenesisA new role of the Rac-GAP β2-chimaerin in cell adhesion reveals opposite functions in breast cancer initiation and tumor progression.Identification of p130Cas/ErbB2-dependent invasive signatures in transformed mammary epithelial cells.Putative biomarkers and therapeutic targets associated with radiation resistance.Targeting tumour hypoxia to prevent cancer metastasis. From biology, biosensing and technology to drug development: the METOXIA consortium.Transcriptome- and proteome-oriented identification of dysregulated eIF4G, STAT3, and Hippo pathways altered by PIK3CA H1047R in HER2/ER-positive breast cancer.Rac1 as a multifunctional therapeutic target to prevent and combat cancer metastasisIntegrin β1: A Mechanosignaling Sensor Essential for Connective Tissue Deposition by Fibroblasts.Frizzled 8 promotes the cell proliferation and metastasis of renal cell carcinoma.The Level of TWIST1 expression determines the response of colon cancer cells to mitogen-activated protein kinases inhibitors.The crosstalk between breast carcinoma-associated fibroblasts and cancer cells promotes RhoA-dependent invasion via IGF-1 and PAI-1.Genome-Wide Inhibition of Pro-atherogenic Gene Expression by Multi-STAT Targeting Compounds as a Novel Treatment Strategy of CVDs
P2860
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P2860
Targeting of Rac GTPases blocks the spread of intact human breast cancer.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Targeting of Rac GTPases blocks the spread of intact human breast cancer.
@ast
Targeting of Rac GTPases blocks the spread of intact human breast cancer.
@en
type
label
Targeting of Rac GTPases blocks the spread of intact human breast cancer.
@ast
Targeting of Rac GTPases blocks the spread of intact human breast cancer.
@en
prefLabel
Targeting of Rac GTPases blocks the spread of intact human breast cancer.
@ast
Targeting of Rac GTPases blocks the spread of intact human breast cancer.
@en
P2093
P2860
P50
P356
P1433
P1476
Targeting of Rac GTPases blocks the spread of intact human breast cancer
@en
P2093
Duncan Sproul
Helen Caldwell
Michael J Dixon
P2860
P304
P356
10.18632/ONCOTARGET.520
P407
P577
2012-06-01T00:00:00Z