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Lipid receptors and islet function: therapeutic implications?

Lipid receptors and islet function: therapeutic implications?

http://www.wikidata.org/entity/Q33930824

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Glucose activates free fatty acid receptor 1 gene transcription via phosphatidylinositol-3-kinase-dependent O-GlcNAcylation of pancreas-duodenum homeobox-1 Membrane Potential and Calcium Dynamics in Beta Cells from Mouse Pancreas Tissue Slices: Theory, Experimentation, and Analysis Potential roles of GPR120 and its agonists in the management of diabetes Mechanisms of gene regulation by fatty acids Omega-3 Fatty Acids and FFAR4 Computational modeling of glucose transport in pancreatic β-cells identifies metabolic thresholds and therapeutic targets in diabetes An siRNA screen in pancreatic beta cells reveals a role for Gpr27 in insulin production AMP-activated protein kinase (AMPK) mediates nutrient regulation of thioredoxin-interacting protein (TXNIP) in pancreatic beta-cells GPR120 (FFAR4) is preferentially expressed in pancreatic delta cells and regulates somatostatin secretion from murine islets of Langerhans.The dual DPP4 inhibitor and GPR119 agonist HBK001 regulates glycemic control and beta cell function ex and in vivo Alteration of the glucagon axis in GPR120 (FFAR4) knockout mice: a role for GPR120 in glucagon secretion.A role for cytosolic isocitrate dehydrogenase as a negative regulator of glucose signaling for insulin secretion in pancreatic ß-cells.Differential Gene Expression in GPR40-Overexpressing Pancreatic β-cells Treated with Linoleic Acid.Inhibition of Id1 augments insulin secretion and protects against high-fat diet-induced glucose intolerance.The short-chain fatty acid receptor, FFA2, contributes to gestational glucose homeostasis.Targeting GPR120 and other fatty acid-sensing GPCRs ameliorates insulin resistance and inflammatory diseases.GPR40 modulators: new kid on the block Failure of the adaptive unfolded protein response in islets of obese mice is linked with abnormalities in β-cell gene expression and progression to diabetes Deficiency of G-protein coupled receptor 40, a lipid-activated receptor, heightens in vitro- and in vivo-induced murine osteoarthritis.Drugs or diet?--Developing novel therapeutic strategies targeting the free fatty acid family of GPCRs β-Hydroxybutyrate modulates N-type calcium channels in rat sympathetic neurons by acting as an agonist for the G-protein-coupled receptor FFA3.Pathway to diabetes through attenuation of pancreatic beta cell glycosylation and glucose transport.The future of incretin-based therapy: novel avenues--novel targets.Dietary fatty acids linking postprandial metabolic response and chronic diseases.Diabetes mellitus and the β cell: the last ten years.Low affinity GPCRs for metabolic intermediates: challenges for pharmacologists.Evolving therapeutic options for type 2 diabetes mellitus: an overview.Minireview: The effects of species ortholog and SNP variation on receptors for free fatty acids.Review of insulin-dependent and insulin-independent agents for treating patients with type 2 diabetes mellitus and potential role for sodium-glucose co-transporter 2 inhibitors.Continual evolution of type 2 diabetes: an update on pathophysiology and emerging treatment options Therapeutic application of GPR119 ligands in metabolic disorders.Molecular mechanisms of target recognition by lipid GPCRs: relevance for cancer.G protein-coupled receptors: signalling and regulation by lipid agonists for improved glucose homoeostasis.Evaluation of the insulin-releasing and glucose-lowering effects of GPR120 activation in pancreatic β-cells.FFAR3 modulates insulin secretion and global gene expression in mouse islets.Polymorphic Variation in FFA Receptors: Functions and Consequences.In vitro and mouse in vivo characterization of the potent free fatty acid 1 receptor agonist TUG-469.Chemically engineering ligand selectivity at the free fatty acid receptor 2 based on pharmacological variation between species orthologs.Conjugated linoleic acids mediate insulin release through islet G protein-coupled receptor FFA1/GPR40.Characterization of the post-prandial insulinemic response and low glycaemic index of a soy beverage.

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P2860

Lipid receptors and islet function: therapeutic implications?

http://www.wikidata.org/entity/Q33930824

description

2009 nî lūn-bûn

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2009 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի նոյեմբերին հրատարակված գիտական հոդված

@hy

2009年の論文

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2009年論文

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2009年論文

@zh-hant

2009年論文

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2009年論文

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2009年論文

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2009年论文

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name

Lipid receptors and islet function: therapeutic implications?

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Lipid receptors and islet function: therapeutic implications?

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Lipid receptors and islet function: therapeutic implications?

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Lipid receptors and islet function: therapeutic implications?

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Lipid receptors and islet function: therapeutic implications?

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J.1463-1326.2009.01114.X

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Diabetes, Obesity and Metabolism

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Lipid receptors and islet function: therapeutic implications?

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M A Kebede

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M G Latour

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T Alquier

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V Poitout

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P2860

Short-chain fatty acids stimulate leptin production in adipocytes through the G protein-coupled receptor GPR41

A cluster of four novel human G protein-coupled receptor genes occurring in close proximity to CD22 gene on chromosome 19q13.1

The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids

Endogenous and synthetic agonists of GPR119 differ in signalling pathways and their effects on insulin secretion in MIN6c4 insulinoma cells

Mechanisms and physiological significance of the cholinergic control of pancreatic beta-cell function.

The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids.

A human cell surface receptor activated by free fatty acids and thiazolidinedione drugs.

Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40.

Oleic acid interacts with GPR40 to induce Ca2+ signaling in rat islet beta-cells: mediation by PLC and L-type Ca2+ channel and link to insulin release.

Role of GPR40 in fatty acid action on the beta cell line INS-1E.

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10-20

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scholarly article

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10.1111/J.1463-1326.2009.01114.X

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11 Suppl 4

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2009-11-01T00:00:00Z

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