Herpes simplex virus type 1 latency-associated transcription unit promotes anatomical site-dependent establishment and reactivation from latency.
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Potential role for luman, the cellular homologue of herpes simplex virus VP16 (alpha gene trans-inducing factor), in herpesvirus latencyThe probability of in vivo reactivation of herpes simplex virus type 1 increases with the number of latently infected neurons in the ganglia.Macrophages and cytokines in the early defence against herpes simplex virusBovine Herpes Virus 1 (BHV-1) and Herpes Simplex Virus Type 1 (HSV-1) Promote Survival of Latently Infected Sensory Neurons, in Part by Inhibiting ApoptosisOcular herpes simplex virus: how are latency, reactivation, recurrent disease and therapy interrelated?Inhibition of herpes simplex virus reactivation by dipyridamoleIdentification and Function of MicroRNAs Encoded by HerpesvirusesLaser-capture microdissection: refining estimates of the quantity and distribution of latent herpes simplex virus 1 and varicella-zoster virus DNA in human trigeminal Ganglia at the single-cell level.De novo synthesis of VP16 coordinates the exit from HSV latency in vivo.A herpes simplex virus type 1 latency-associated transcript mutant with increased virulence and reduced spontaneous reactivationTowards an understanding of the herpes simplex virus type 1 latency-reactivation cycleThe locus encompassing the latency-associated transcript of herpes simplex virus type 1 interferes with and delays interferon expression in productively infected neuroblastoma cells and trigeminal Ganglia of acutely infected mice.Human thymidine kinase can functionally replace herpes simplex virus type 1 thymidine kinase for viral replication in mouse sensory ganglia and reactivation from latency upon explant.Alternative splicing of the latency-related transcript of bovine herpesvirus 1 yields RNAs containing unique open reading framesThe latent herpes simplex virus type 1 genome copy number in individual neurons is virus strain specific and correlates with reactivationImmunohistochemical analysis of primary sensory neurons latently infected with herpes simplex virus type 1.Long-term transgene expression in mice infected with a herpes simplex virus type 1 mutant severely impaired for immediate-early gene expression.Replication of herpes simplex virus type 1 within trigeminal ganglia is required for high frequency but not high viral genome copy number latency.The latency-associated transcript gene enhances establishment of herpes simplex virus type 1 latency in rabbits.Evidence for a bidirectional element located downstream from the herpes simplex virus type 1 latency-associated promoter that increases its activity during latencyAnalysis of protein expression from within the region encoding the 2.0-kilobase latency-associated transcript of herpes simplex virus type 1Enhancer and long-term expression functions of herpes simplex virus type 1 latency-associated promoter are both located in the same regionICP0, ICP4, or VP16 expressed from adenovirus vectors induces reactivation of latent herpes simplex virus type 1 in primary cultures of latently infected trigeminal ganglion cells.Three herpes simplex virus type 1 latency-associated transcript mutants with distinct and asymmetric effects on virulence in mice compared with rabbits.The 2.2-kilobase latency-associated transcript of herpes simplex virus type 2 does not modulate viral replication, reactivation, or establishment of latency in transgenic miceHerpes simplex virus type 1 2-kilobase latency-associated transcript intron associates with ribosomal proteins and splicing factors.Rapid in vivo reactivation of herpes simplex virus in latently infected murine ganglionic neurons after transient hyperthermia.A herpes simplex virus type 1 mutant expressing a baculovirus inhibitor of apoptosis gene in place of latency-associated transcript has a wild-type reactivation phenotype in the mouse.HSV-1-based vectors for gene therapy of neurological diseases and brain tumors: part I. HSV-1 structure, replication and pathogenesis.A gene capable of blocking apoptosis can substitute for the herpes simplex virus type 1 latency-associated transcript gene and restore wild-type reactivation levelsA mutation in the latency-related gene of bovine herpesvirus 1 disrupts the latency reactivation cycle in calves.Regions of the herpes simplex virus type 1 latency-associated transcript that protect cells from apoptosis in vitro and protect neuronal cells in vivo.MicroRNAs expressed by herpes simplex virus 1 during latent infection regulate viral mRNAsTegument protein control of latent herpesvirus establishment and animation.The stable 2.0-kilobase intron of the herpes simplex virus type 1 latency-associated transcript does not function as an antisense repressor of ICP0 in nonneuronal cellsInfection of cattle with a bovine herpesvirus 1 strain that contains a mutation in the latency-related gene leads to increased apoptosis in trigeminal ganglia during the transition from acute infection to latency.A novel herpes simplex virus type 1 transcript (AL-RNA) antisense to the 5' end of the latency-associated transcript produces a protein in infected rabbits.Herpes simplex virus type 1 latently infected neurons differentially express latency-associated and ICP0 transcripts.Herpes simplex virus type 1 and bovine herpesvirus 1 latency.Herpes simplex virus 2 microRNA miR-H6 is a novel latency-associated transcript-associated microRNA, but reduction of its expression does not influence the establishment of viral latency or the recurrence phenotype.
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P2860
Herpes simplex virus type 1 latency-associated transcription unit promotes anatomical site-dependent establishment and reactivation from latency.
description
1992 nî lūn-bûn
@nan
1992 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
1992 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
1992年の論文
@ja
1992年論文
@yue
1992年論文
@zh-hant
1992年論文
@zh-hk
1992年論文
@zh-mo
1992年論文
@zh-tw
1992年论文
@wuu
name
Herpes simplex virus type 1 la ...... and reactivation from latency.
@ast
Herpes simplex virus type 1 la ...... and reactivation from latency.
@en
type
label
Herpes simplex virus type 1 la ...... and reactivation from latency.
@ast
Herpes simplex virus type 1 la ...... and reactivation from latency.
@en
prefLabel
Herpes simplex virus type 1 la ...... and reactivation from latency.
@ast
Herpes simplex virus type 1 la ...... and reactivation from latency.
@en
P2860
P1433
P1476
Herpes simplex virus type 1 la ...... and reactivation from latency.
@en
P2093
N M Sawtell
R L Thompson
P2860
P304
P407
P577
1992-04-01T00:00:00Z