Diabetogenic T cells recognize insulin bound to IAg7 in an unexpected, weakly binding register. - Wikidata - wikimedia - TriplyDB

Diabetogenic T cells recognize insulin bound to IAg7 in an unexpected, weakly binding register.

Diabetogenic T cells recognize insulin bound to IAg7 in an unexpected, weakly binding register.

http://www.wikidata.org/entity/Q33934705

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Human leukocyte Antigen-DM polymorphisms in autoimmune diseases Beta cell antigens in type 1 diabetes: triggers in pathogenesis and therapeutic targets MHC Class II Auto-Antigen Presentation is Unconventional Targeting the trimolecular complex Risk factors and primary prevention trials for type 1 diabetes Immunotherapy in autoimmune type 1 diabetes Bidirectional binding of invariant chain peptides to an MHC class II molecule Structure of a TCR with high affinity for self-antigen reveals basis for escape from negative selection Molecular Interactions Governing Autoantigen Presentation in Type 1 Diabetes T cells and their eons-old obsession with MHC Type 1 diabetes: translating mechanistic observations into effective clinical outcomes Insulin as a key autoantigen in the development of type 1 diabetes Autoimmune responses in T1DM: quantitative methods to understand onset, progression, and prevention of disease TCR affinity and tolerance mechanisms converge to shape T cell diabetogenic potential.γδ T cells recognize the insulin B:9-23 peptide antigen when it is dimerized through thiol oxidation.Prevention of type 1 diabetes in mice by tolerogenic vaccination with a strong agonist insulin mimetope Extra-thymically induced regulatory T cells: do they have potential in disease prevention?Structure-based selection of small molecules to alter allele-specific MHC class II antigen presentation Low 2-dimensional CD4 T cell receptor affinity for myelin sets in motion delayed response kinetics.Treg vaccination with a strong-agonistic insulin mimetope.Autoreactive T cells specific for insulin B:11-23 recognize a low-affinity peptide register in human subjects with autoimmune diabetes Flanking residues are central to DO11.10 T cell hybridoma stimulation by ovalbumin 323-339.Reduction of T cell receptor diversity in NOD mice prevents development of type 1 diabetes but not Sjögren's syndrome.Divergent paths for the selection of immunodominant epitopes from distinct antigenic sources.T cell receptor recognition of self and foreign antigens in the induction of autoimmunity.Treg vaccination in autoimmune type 1 diabetes.A missing PD-L1/PD-1 coinhibition regulates diabetes induction by preproinsulin-specific CD8 T-cells in an epitope-specific manner T cell receptor cross-reactivity between similar foreign and self peptides influences naive cell population size and autoimmunity.Immune intervention in type 1 diabetes.Cell-surface MHC density profiling reveals instability of autoimmunity-associated HLA.Specificity and detection of insulin-reactive CD4+ T cells in type 1 diabetes in the nonobese diabetic (NOD) mouse.Regulatory vs. inflammatory cytokine T-cell responses to mutated insulin peptides in healthy and type 1 diabetic subjects.Type 1 diabetes: A predictable disease.Opposing signals from the Bcl6 transcription factor and the interleukin-2 receptor generate T helper 1 central and effector memory cells.Evolutionarily conserved features contribute to αβ T cell receptor specificity Register shifting of an insulin peptide-MHC complex allows diabetogenic T cells to escape thymic deletion How does type 1 diabetes develop?: the notion of homicide or β-cell suicide revisited.T cells in the control of organ-specific autoimmunity Germline TRAV5D-4 T-cell receptor sequence targets a primary insulin peptide of NOD mice.Prevention of type 1 diabetes in the rat with an allele-specific anti-T-cell receptor antibody: Vβ13 as a therapeutic target and biomarker

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P2860

Diabetogenic T cells recognize insulin bound to IAg7 in an unexpected, weakly binding register.

http://www.wikidata.org/entity/Q33934705

description

2010 nî lūn-bûn

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2010 թուականի Յունիսին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի հունիսին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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Diabetogenic T cells recognize ...... cted, weakly binding register.

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Diabetogenic T cells recognize ...... cted, weakly binding register.

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Proceedings of the National Academy of Sciences of the United States of America

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Diabetogenic T cells recognize ...... cted, weakly binding register.

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Brian D Stadinski

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Frances Crawford

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George S Eisenbarth

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Li Zhang

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P2860

Chromogranin A is an autoantigen in type 1 diabetes

Mimotopes for alloreactive and conventional T cells in a peptide-MHC display library

A structural framework for deciphering the link between I-Ag7 and autoimmune diabetes

Structural basis of peptide binding and presentation by the type I diabetes-associated MHC class II molecule of NOD mice

Structural and functional consequences of altering a peptide MHC anchor residue

Structure of a human insulin peptide-HLA-DQ8 complex and susceptibility to type 1 diabetes

Structural snapshot of aberrant antigen presentation linked to autoimmunity: the immunodominant epitope of MBP complexed with I-Au

SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling

HLA DR-DQ haplotypes and genotypes and type 1 diabetes risk: analysis of the type 1 diabetes genetics consortium families

The I-Ag7 MHC class II molecule linked to murine diabetes is a promiscuous peptide binder.

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107

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Philippa Marrack

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2890771

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