Register shifting of an insulin peptide-MHC complex allows diabetogenic T cells to escape thymic deletion
about
Human leukocyte Antigen-DM polymorphisms in autoimmune diseasesBeta cell antigens in type 1 diabetes: triggers in pathogenesis and therapeutic targetsMHC Class II Auto-Antigen Presentation is UnconventionalType 1 diabetes: translating mechanistic observations into effective clinical outcomesVasostatin-1 antigenic epitope mapping for induction of cellular and humoral immune responses to chromogranin A autoantigen in NOD micePathways of antigen processing.TCR affinity and tolerance mechanisms converge to shape T cell diabetogenic potential.γδ T cells recognize the insulin B:9-23 peptide antigen when it is dimerized through thiol oxidation.The central role of antigen presentation in islets of Langerhans in autoimmune diabetesOn the perils of poor editing: regulation of peptide loading by HLA-DQ and H2-A molecules associated with celiac disease and type 1 diabetes.ZnT8-reactive T cells are weakly pathogenic in NOD mice but can participate in diabetes under inflammatory conditionsAutoreactive T cells specific for insulin B:11-23 recognize a low-affinity peptide register in human subjects with autoimmune diabetesReduction of T cell receptor diversity in NOD mice prevents development of type 1 diabetes but not Sjögren's syndrome.BDC12-4.1 T-cell receptor transgenic insulin-specific CD4 T cells are resistant to in vitro differentiation into functional Foxp3+ T regulatory cells.Divergent paths for the selection of immunodominant epitopes from distinct antigenic sources.The nonconventional MHC class II molecule DM governs diabetes susceptibility in NOD miceA missing PD-L1/PD-1 coinhibition regulates diabetes induction by preproinsulin-specific CD8 T-cells in an epitope-specific mannerT cells in the control of organ-specific autoimmunityMechanisms of human autoimmunity.Following the fate of one insulin-reactive CD4 T cell: conversion into Teffs and Tregs in the periphery controls diabetes in NOD mice.Beta cells transfer vesicles containing insulin to phagocytes for presentation to T cells.Current and future immunomodulation strategies to restore tolerance in autoimmune diseases.Tolerant anti-insulin B cells are effective APCsGeorge S. Eisenbarth: insulin and type 1 diabetes.Class-switched anti-insulin antibodies originate from unconventional antigen presentation in multiple lymphoid sites.Progress and challenges for treating Type 1 diabetes.Antigen presentation events during the initiation of autoimmune diabetes in the NOD mousePeripherally induced tregs - role in immune homeostasis and autoimmunityThe role of islet antigen presenting cells and the presentation of insulin in the initiation of autoimmune diabetes in the NOD mouse.Pathogenic mechanisms in type 1 diabetes: the islet is both target and driver of disease.Mechanisms of peptide repertoire selection by HLA-DMPathogenic CD4⁺ T cells recognizing an unstable peptide of insulin are directly recruited into islets bypassing local lymph nodes.PD-1 pathway-mediated regulation of islet-specific CD4+ T cell subsets in autoimmune diabetesInsulinoma-released exosomes activate autoreactive marginal zone-like B cells that expand endogenously in prediabetic NOD mice.Monoclonal antibody blocking the recognition of an insulin peptide-MHC complex modulates type 1 diabetes.Cutting edge: type 1 diabetes occurs despite robust anergy among endogenous insulin-specific CD4 T cells in NOD miceThe multiple origins of Type 1 diabetes.A novel pathway of presentation by class II-MHC molecules involving peptides or denatured proteins important in autoimmunity.The Repertoires of Peptides Presented by MHC-II in the Thymus and in Peripheral Tissue: A Clue for Autoimmunity?Antigen-specific therapy against type 1 diabetes: mechanisms and perspectives.
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P2860
Register shifting of an insulin peptide-MHC complex allows diabetogenic T cells to escape thymic deletion
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Register shifting of an insuli ...... ells to escape thymic deletion
@ast
Register shifting of an insuli ...... ells to escape thymic deletion
@en
type
label
Register shifting of an insuli ...... ells to escape thymic deletion
@ast
Register shifting of an insuli ...... ells to escape thymic deletion
@en
prefLabel
Register shifting of an insuli ...... ells to escape thymic deletion
@ast
Register shifting of an insuli ...... ells to escape thymic deletion
@en
P2860
P356
P1476
Register shifting of an insuli ...... ells to escape thymic deletion
@en
P2093
James F Mohan
Shirley J Petzold
P2860
P304
P356
10.1084/JEM.20111502
P407
P577
2011-11-07T00:00:00Z