Anti-human immunodeficiency virus type 1 activity and resistance profile of 2',3'-didehydro-3'-deoxy-4'-ethynylthymidine in vitro
about
From the chemistry of epoxy-sugar nucleosides to the discovery of anti-HIV agent 4'-ethynylstavudine-FestinavirComparison of the phosphorylation of 4'-ethynyl 2',3'-dihydro-3'-deoxythymidine with that of other anti-human immunodeficiency virus thymidine analogs.Balancing antiviral potency and host toxicity: identifying a nucleotide inhibitor with an optimal kinetic phenotype for HIV-1 reverse transcriptase.The Nucleoside Analog BMS-986001 Shows Greater In Vitro Activity against HIV-2 than against HIV-1.Intracellular metabolism and persistence of the anti-human immunodeficiency virus activity of 2',3'-didehydro-3'-deoxy-4'-ethynylthymidine, a novel thymidine analog.Mechanism of inhibition of human immunodeficiency virus type 1 reverse transcriptase by a stavudine analogue, 4'-ethynyl stavudine triphosphatePractical Considerations For Developing Nucleoside Reverse Transcriptase Inhibitors.Retention of metabolites of 2',3'-didehydro-3'-deoxy-4'-ethynylthymidine, a novel anti-human immunodeficiency virus type 1 thymidine analog, in cellsImpact of novel human immunodeficiency virus type 1 reverse transcriptase mutations P119S and T165A on 4'-ethynylthymidine analog resistance profile.Mechanism of inhibition of HIV-1 reverse transcriptase by 4'-Ethynyl-2-fluoro-2'-deoxyadenosine triphosphate, a translocation-defective reverse transcriptase inhibitor.Novel compounds for the treatment of HIV type-1 infection.Selective inhibition of porcine endogenous retrovirus replication in human cells by acyclic nucleoside phosphonates.4'-Ethynylstavudine (4'-Ed4T) has potent anti-HIV-1 activity with reduced toxicity and shows a unique activity profile against drug-resistant mutants.In vitro cross-resistance profile of nucleoside reverse transcriptase inhibitor (NRTI) BMS-986001 against known NRTI resistance mutations.Xenotropic murine leukemia virus-related virus is susceptible to AZT.Nonclinical Safety Profile of BMS-986001, a Nucleoside Transcriptase Inhibitor for Combination Retroviral Therapy.An alternative synthetic method for 4'-C-ethynylstavudine by means of nucleophilic substitution of 4'-benzoyloxythymine nucleoside.Synthetic use of epoxy-sugar nucleosides.A guided tour through the antiviral drug field
P2860
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P2860
Anti-human immunodeficiency virus type 1 activity and resistance profile of 2',3'-didehydro-3'-deoxy-4'-ethynylthymidine in vitro
description
2005 nî lūn-bûn
@nan
2005 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2005年の論文
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2005年学术文章
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2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
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2005年學術文章
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name
Anti-human immunodeficiency vi ...... y-4'-ethynylthymidine in vitro
@ast
Anti-human immunodeficiency vi ...... y-4'-ethynylthymidine in vitro
@en
type
label
Anti-human immunodeficiency vi ...... y-4'-ethynylthymidine in vitro
@ast
Anti-human immunodeficiency vi ...... y-4'-ethynylthymidine in vitro
@en
prefLabel
Anti-human immunodeficiency vi ...... y-4'-ethynylthymidine in vitro
@ast
Anti-human immunodeficiency vi ...... y-4'-ethynylthymidine in vitro
@en
P2093
P2860
P1476
Anti-human immunodeficiency vi ...... y-4'-ethynylthymidine in vitro
@en
P2093
Hiroki Kumamoto
Hiromichi Tanaka
Kazuhiro Haraguchi
Masanori Baba
Takao Nitanda
Yung-Chi Cheng
P2860
P304
P356
10.1128/AAC.49.8.3355-3360.2005
P407
P577
2005-08-01T00:00:00Z