about
Structure based approaches for targeting non-coding RNAs with small moleculesOral administration of erythromycin decreases RNA toxicity in myotonic dystrophyDesign of a bioactive small molecule that targets r(AUUCU) repeats in spinocerebellar ataxia 10Studying a Drug-like, RNA-Focused Small Molecule Library Identifies Compounds That Inhibit RNA Toxicity in Myotonic DystrophyBiological Efficacy and Toxicity of Diamidines in Myotonic Dystrophy Type 1 Models.Targeting toxic RNAs that cause myotonic dystrophy type 1 (DM1) with a bisamidinium inhibitor.MBNL proteins and their target RNAs, interaction and splicing regulation.Synthesis of N-substituted aryl amidines by strong base activation of amines.Therapeutic impact of systemic AAV-mediated RNA interference in a mouse model of myotonic dystrophy.In silico discovery of substituted pyrido[2,3-d]pyrimidines and pentamidine-like compounds with biological activity in myotonic dystrophy models.Actinomycin D Specifically Reduces Expanded CUG Repeat RNA in Myotonic Dystrophy Models.Pentamidine rescues contractility and rhythmicity in a Drosophila model of myotonic dystrophy heart dysfunction.In Vitro and In Vivo Modulation of Alternative Splicing by the Biguanide MetforminDevelopmental insights into the pathology of and therapeutic strategies for DM1: Back to the basics.Development of pharmacophore models for small molecules targeting RNA: Application to the RNA repeat expansion in myotonic dystrophy type 1.Myotonic dystrophy: approach to therapy.HIV-1 Frameshift RNA-Targeted Triazoles Inhibit Propagation of Replication-Competent and Multi-Drug-Resistant HIV in Human Cells.Dmpk gene deletion or antisense knockdown does not compromise cardiac or skeletal muscle function in miceCells of Matter-In Vitro Models for Myotonic Dystrophy.Small Molecules Which Improve Pathogenesis of Myotonic Dystrophy Type 1.miR-23b and miR-218 silencing increase Muscleblind-like expression and alleviate myotonic dystrophy phenotypes in mammalian models.
P2860
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P2860
description
2013 nî lūn-bûn
@nan
2013 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Reducing levels of toxic RNA with small molecules
@ast
Reducing levels of toxic RNA with small molecules
@en
type
label
Reducing levels of toxic RNA with small molecules
@ast
Reducing levels of toxic RNA with small molecules
@en
prefLabel
Reducing levels of toxic RNA with small molecules
@ast
Reducing levels of toxic RNA with small molecules
@en
P2093
P2860
P356
P1433
P1476
Reducing levels of toxic RNA with small molecules
@en
P2093
Aaron G Docter
Cameron L Hilton
Charles A Thornton
J Andrew Berglund
Leslie A Coonrod
Micah J Bodner
Michael M Haley
Ruth B Siboni
Samuel Carrell
Wenli Wang
P2860
P304
P356
10.1021/CB400431F
P50
P577
2013-09-27T00:00:00Z