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The ups and downs of p53: understanding protein dynamics in single cells

The ups and downs of p53: understanding protein dynamics in single cells

http://www.wikidata.org/entity/Q33941653

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Caspase-2-mediated cleavage of Mdm2 creates a p53-induced positive feedback loop The RNA Splicing Response to DNA Damage The DNA Damage Response: Making It Safe to Play with Knives The cyclin-dependent kinase inhibitor p21 is regulated by RNA-binding protein PCBP4 via mRNA stability Toxicity testing in the 21 century: defining new risk assessment approaches based on perturbation of intracellular toxicity pathways Prolonged mitotic arrest triggers partial activation of apoptosis, resulting in DNA damage and p53 induction A light-inducible organelle-targeting system for dynamically activating and inactivating signaling in budding yeast Dynamics of p53 and NF-κB regulation in response to DNA damage and identification of target proteins suitable for therapeutic intervention.Statistical model comparison applied to common network motifs Stress-specific response of the p53-Mdm2 feedback loop Interplay between Mdm2 and HIPK2 in the DNA damage response.The regulation of the p53-mediated stress response by MDM2 and MDM4.Response acceleration in post-translationally regulated genetic circuits.Downregulation of VRK1 by p53 in response to DNA damage is mediated by the autophagic pathway.Simulating quantitative cellular responses using asynchronous threshold Boolean network ensembles.Noise amplification in human tumor suppression following gamma irradiation.Identification of novel targets for breast cancer by exploring gene switches on a genome scale.Modeling the basal dynamics of p53 system.Probabilistic reconstruction of the tumor progression process in gene regulatory networks in the presence of uncertainty.Differential gene expression regulated by oscillatory transcription factors.Coordination between cell cycle progression and cell fate decision by the p53 and E2F1 pathways in response to DNA damage.Dynamic modelling of oestrogen signalling and cell fate in breast cancer cells The p53 network: cellular and systemic DNA damage responses in aging and cancer.Tension and robustness in multitasking cellular networks.Stochastic Boolean networks: an efficient approach to modeling gene regulatory networks.New insights into the link between DNA damage and apoptosis.A protein turnover signaling motif controls the stimulus-sensitivity of stress response pathways An evolutionary firefly algorithm for the estimation of nonlinear biological model parameters Boolean network model for cancer pathways: predicting carcinogenesis and targeted therapy outcomes Two-phase dynamics of p53 in the DNA damage response.The p53 response in single cells is linearly correlated to the number of DNA breaks without a distinct threshold.Computational analysis of signaling patterns in single cells.Gene perturbation and intervention in context-sensitive stochastic Boolean networks.The role of mRNA decay in p53-induced gene expression Single-cell protein analysis Precritical State Transition Dynamics in the Attractor Landscape of a Molecular Interaction Network Underlying Colorectal Tumorigenesis.Design principles of cell circuits with paradoxical components.Human umbilical cord blood-derived mesenchymal stem cells undergo cellular senescence in response to oxidative stress.Identification of control targets in Boolean molecular network models via computational algebra.Photonic gene circuits by optically addressable siRNA-Au nanoantennas

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P2860

The ups and downs of p53: understanding protein dynamics in single cells

http://www.wikidata.org/entity/Q33941653

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2009 nî lūn-bûn

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2009 թուականի Ապրիլին հրատարակուած գիտական յօդուած

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2009 թվականի ապրիլին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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The ups and downs of p53: understanding protein dynamics in single cells

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The ups and downs of p53: understanding protein dynamics in single cells

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The ups and downs of p53: understanding protein dynamics in single cells

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The ups and downs of p53: understanding protein dynamics in single cells

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Nature Reviews Cancer

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The ups and downs of p53: understanding protein dynamics in single cells

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Alexander Loewer

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Eric Batchelor

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Galit Lahav

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P2860

Explaining oscillations and variability in the p53-Mdm2 system

A quantitative description of membrane current and its application to conduction and excitation in nerve

Thresholds and plateaus in the Hodgkin-Huxley nerve equations

ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex

An acetylation switch in p53 mediates holo-TFIID recruitment

ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints

Impulses and Physiological States in Theoretical Models of Nerve Membrane.

Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro

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