The Down syndrome-related protein kinase DYRK1A phosphorylates p27(Kip1) and Cyclin D1 and induces cell cycle exit and neuronal differentiation - Wikidata - wikimedia - TriplyDB

The Down syndrome-related protein kinase DYRK1A phosphorylates p27(Kip1) and Cyclin D1 and induces cell cycle exit and neuronal differentiation

The Down syndrome-related protein kinase DYRK1A phosphorylates p27(Kip1) and Cyclin D1 and induces cell cycle exit and neuronal differentiation

http://www.wikidata.org/entity/Q33952905

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DYRK1A, a Dosage-Sensitive Gene Involved in Neurodevelopmental Disorders, Is a Target for Drug Development in Down Syndrome Case report of novel DYRK1A mutations in 2 individuals with syndromic intellectual disability and a review of the literature Cyclin D1 Again Caught in the Act: Dyrk1a Links G1 and Neurogenesis in Down Syndrome The adaptor protein DCAF7 mediates the interaction of the adenovirus E1A oncoprotein with the protein kinases DYRK1A and HIPK2 Selectivity Profiling and Biological Activity of Novel β-Carbolines as Potent and Selective DYRK1 Kinase Inhibitors The biology, pathogenesis and clinical aspects of acute lymphoblastic leukemia in children with Down syndrome.The Tumor Suppressor NKX3.1 Is Targeted for Degradation by DYRK1B Kinase DYRK1A controls the transition from proliferation to quiescence during lymphoid development by destabilizing Cyclin D3 Autism spectrum disorder and epilepsy: Disorders with a shared biology.Ten new cases further delineate the syndromic intellectual disability phenotype caused by mutations in DYRK1A.DYRK1A overexpression enhances STAT activity and astrogliogenesis in a Down syndrome mouse model.Inhibition of DYRK1A Stimulates Human β-Cell Proliferation E3 Ligase SCFβTrCP-induced DYRK1A Protein Degradation Is Essential for Cell Cycle Progression in HEK293 Cells.Generation of improved human cerebral organoids from single copy DYRK1A knockout induced pluripotent stem cells in trisomy 21: hypothetical solutions for neurodevelopmental models and therapeutic alternatives in down syndrome.DYRK1A: the double-edged kinase as a protagonist in cell growth and tumorigenesis.TGF-β Regulates Survivin to Affect Cell Cycle and the Expression of EGFR and MMP9 in Glioblastoma.RETRACTED: SDF-1/CXCR4 Axis Regulates Cell Cycle Progression and Epithelial-Mesenchymal Transition via Up-regulation of Survivin in Glioblastoma.A cluster of protein kinases and phosphatases modulated in fetal Down syndrome (trisomy 21) brain.DYRK1A-mediated Cyclin D1 Degradation in Neural Stem Cells Contributes to the Neurogenic Cortical Defects in Down Syndrome.DYRK1B mutations associated with metabolic syndrome impair the chaperone-dependent maturation of the kinase domain.Dual-specificity tyrosine-phosphorylation regulated kinase 1A Gene Transcription is regulated by Myocyte Enhancer Factor 2D Potential Role of Microtubule Stabilizing Agents in Neurodevelopmental Disorders.Identification of DYRK1B as a substrate of ERK1/2 and characterisation of the kinase activity of DYRK1B mutants from cancer and metabolic syndrome.Zebrafish knockout of Down syndrome gene, DYRK1A, shows social impairments relevant to autism.Inhibition of DYRK1A disrupts neural lineage specification in human pluripotent stem cells Effect of tyrosine autophosphorylation on catalytic activity and subcellular localisation of homeodomain-interacting protein kinases (HIPK).DYRK1A regulates Hap1-Dcaf7/WDR68 binding with implication for delayed growth in Down syndrome.Live imaging of transforming growth factor-β activated kinase 1 activation in Lewis lung carcinoma 3LL cells implanted into syngeneic mice and treated with polyinosinic:polycytidylic acid.Metabolic and Growth Rate Alterations in Lymphoblastic Cell Lines Discriminate Between Down Syndrome and Alzheimer's Disease.A wake-up call to quiescent cancer cells - potential use of DYRK1B inhibitors in cancer therapy.Marine-Derived 2-Aminoimidazolone Alkaloids. Leucettamine B-Related Polyandrocarpamines Inhibit Mammalian and Protozoan DYRK & CLK Kinases.Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors: a survey of recent patent literature.nNOS Translocates into the Nucleus and Interacts with Sox2 to Protect Neurons Against Early Excitotoxicity via Promotion of Shh Transcription.Muscle stem cell dysfunction impairs muscle regeneration in a mouse model of Down syndrome.The Temporal Regulation of S Phase Proteins During G1.Dyrk1a regulates the cardiomyocyte cell cycle via D-cyclin-dependent Rb/E2f-signalling.Correction of cognitive deficits in mouse models of Down syndrome by a pharmacological inhibitor of DYRK1A

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The Down syndrome-related protein kinase DYRK1A phosphorylates p27(Kip1) and Cyclin D1 and induces cell cycle exit and neuronal differentiation

http://www.wikidata.org/entity/Q33952905

description

2014 nî lūn-bûn

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2014 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2014 թվականի մայիսին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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The Down syndrome-related prot ...... t and neuronal differentiation

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The Down syndrome-related prot ...... t and neuronal differentiation

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The Down syndrome-related prot ...... t and neuronal differentiation

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The Down syndrome-related prot ...... t and neuronal differentiation

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The Down syndrome-related prot ...... t and neuronal differentiation

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The Down syndrome-related prot ...... t and neuronal differentiation

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The Down syndrome-related prot ...... t and neuronal differentiation

@en

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Julian Schumacher

http://www.w3.org/2001/XMLSchema#string

Tobias Pasqualon

http://www.w3.org/2001/XMLSchema#string

Ulf Soppa

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Victoria Florencio Ortiz

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P2860

DYRK1A and DYRK3 promote cell survival through phosphorylation and activation of SIRT1

A growth factor-dependent nuclear kinase phosphorylates p27(Kip1) and regulates cell cycle progression.

Phosphorylation-dependent ubiquitination of cyclin D1 by the SCF(FBX4-alphaB crystallin) complex

Extra-cell cycle regulatory functions of cyclin-dependent kinases (CDK) and CDK inhibitor proteins contribute to brain development and neurological disorders

Co-ordination of cell cycle and differentiation in the developing nervous system

Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B

Phosphorylation-dependent regulation of cyclin D1 nuclear export and cyclin D1-dependent cellular transformation

Human minibrain homologue (MNBH/DYRK1): characterization, alternative splicing, differential tissue expression, and overexpression in Down syndrome

Akt-dependent phosphorylation of p27Kip1 promotes binding to 14-3-3 and cytoplasmic localization

Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2

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2084-2100

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scholarly article

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10.4161/CC.29104

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13

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13

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Francisco J. Tejedor

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2014-05-07T00:00:00Z

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24806449

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phosphorylation

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4111700

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