ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration. - Wikidata - wikimedia - TriplyDB

ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration.

ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration.

http://www.wikidata.org/entity/Q33954016

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The amyotrophic lateral sclerosis 8 protein VAPB is cleaved, secreted, and acts as a ligand for Eph receptors Pericytes control key neurovascular functions and neuronal phenotype in the adult brain and during brain aging Biphasic mechanisms of neurovascular unit injury and protection in CNS diseases Development, maintenance and disruption of the blood-brain barrier The pericyte: a forgotten cell type with important implications for Alzheimer's disease?Novel molecular biomarkers at the blood-brain barrier in ALS Microglia centered pathogenesis in ALS: insights in cell interconnectivity Developmental and pathological angiogenesis in the central nervous system Blood-CNS Barrier Impairment in ALS patients versus an animal model Chronic administration of AMD3100 increases survival and alleviates pathology in SOD1(G93A) mice model of ALS In Vivo imaging reveals distinct inflammatory activity of CNS microglia versus PNS macrophages in a mouse model for ALS Aquaporins in the Spinal Cord A perspective on stem cell modeling of amyotrophic lateral sclerosis The blood-spinal cord barrier: morphology and clinical implications The complex molecular biology of amyotrophic lateral sclerosis (ALS)Reactive oxygen species in inflammation and tissue injury Mfsd2a is critical for the formation and function of the blood-brain barrier Reduction of circulating endothelial cells in peripheral blood of ALS patients Phosphatase 2A Inhibition Affects Endoplasmic Reticulum and Mitochondria Homeostasis Via Cytoskeletal Alterations in Brain Endothelial Cells Pharmacological targeting of the PDGF-CC signaling pathway for blood-brain barrier restoration in neurological disorders Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders A genetic model of amyotrophic lateral sclerosis in zebrafish displays phenotypic hallmarks of motoneuron disease Loss of ALS-associated TDP-43 in zebrafish causes muscle degeneration, vascular dysfunction, and reduced motor neuron axon outgrowth.Presymptomatic activation of the PDGF-CC pathway accelerates onset of ALS neurodegeneration.Sporadic ALS has compartment-specific aberrant exon splicing and altered cell-matrix adhesion biology.Interleukin-25 expressed by brain capillary endothelial cells maintains blood-brain barrier function in a protein kinase Cepsilon-dependent manner.T₂-weighted MRI detects presymptomatic pathology in the SOD1 mouse model of ALS.Central nervous system pericytes in health and disease.Roles of vascular endothelial growth factor in amyotrophic lateral sclerosis.Inflammation in ALS and SMA: sorting out the good from the evil.Emerging roles of PGE2 receptors in models of neurological disease.Neurovascular mechanisms and blood-brain barrier disorder in Alzheimer's disease.Impaired spine formation and learning in GPCR kinase 2 interacting protein-1 (GIT1) knockout mice.Disease-related changes in the cerebrospinal fluid metabolome in amyotrophic lateral sclerosis detected by GC/TOFMS.Stem cell-derived motor neurons: applications and challenges in amyotrophic lateral sclerosis.Protein S controls hypoxic/ischemic blood-brain barrier disruption through the TAM receptor Tyro3 and sphingosine 1-phosphate receptor.Apelin deficiency accelerates the progression of amyotrophic lateral sclerosis.Local transplantation of granulocyte colony-stimulating factor-mobilized human peripheral blood mononuclear cells for unhealing bone fractures.NG2+ CNS glial progenitors remain committed to the oligodendrocyte lineage in postnatal life and following neurodegeneration.Effects of caspase-1 knockout on chronic neural recording quality and longevity: insight into cellular and molecular mechanisms of the reactive tissue response.

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P2860

ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration.

http://www.wikidata.org/entity/Q33954016

description

2008 nî lūn-bûn

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2008 թուականի Մարտին հրատարակուած գիտական յօդուած

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2008 թվականի մարտին հրատարակված գիտական հոդված

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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name

ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration.

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ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration.

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type

label

ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration.

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ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration.

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prefLabel

ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration.

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ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration.

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Nature Neuroscience

P1476

ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration.

@en

P2093

Abhay Sagare

http://www.w3.org/2001/XMLSchema#string

Berislav V Zlokovic

http://www.w3.org/2001/XMLSchema#string

Don W Cleveland

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Konstantin Stojanovic

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M Kerry O'Banion

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Margaret Parisi

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Rashid Deane

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Severine Boillee

http://www.w3.org/2001/XMLSchema#string

Yuriy Shapovalov

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Zarina Ali

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P2860

Evidence of compromised blood-spinal cord barrier in early and late symptomatic SOD1 mice modeling ALS

Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation

ALS: a disease of motor neurons and their nonneuronal neighbors

Onset and progression in inherited ALS determined by motor neurons and microglia

Toxicity from different SOD1 mutants dysregulates the complement system and the neuronal regenerative response in ALS motor neurons.

Ultrastructure of blood-brain barrier and blood-spinal cord barrier in SOD1 mice modeling ALS.

Caspase-1 is activated in neural cells and tissue with amyotrophic lateral sclerosis-associated mutations in copper-zinc superoxide dismutase.

Neurovascular mechanisms of Alzheimer's neurodegeneration.

Microglia as potential contributors to motor neuron injury in amyotrophic lateral sclerosis.

VEGF is a modifier of amyotrophic lateral sclerosis in mice and humans and protects motoneurons against ischemic death.

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P304

420-422

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10.1038/NN2073

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P433

4

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11

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2008-03-16T00:00:00Z

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5507312

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18344992

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amyotrophic lateral sclerosis

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2895310

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