Hypersensitive site 2 specifies a unique function within the human beta-globin locus control region to stimulate globin gene transcription.
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Heterogeneous nuclear ribonucleoprotein C1/C2, MeCP1, and SWI/SNF form a chromatin remodeling complex at the beta-globin locus control regionLocus control regionsThe human beta-globin locus control region5'HS5 of the human beta-globin locus control region is dispensable for the formation of the beta-globin active chromatin hub.Mutation of a transcriptional motif of a distant regulatory element reduces the expression of embryonic and fetal globin genes.DNase I hypersensitivity and epsilon-globin transcriptional enhancement are separable in locus control region (LCR) HS1 mutant human beta-globin YAC transgenic miceSynergistic and additive properties of the beta-globin locus control region (LCR) revealed by 5'HS3 deletion mutations: implication for LCR chromatin architecture.Sequences flanking hypersensitive sites of the beta-globin locus control region are required for synergistic enhancementCharacterization of the transcriptome profiles related to globin gene switching during in vitro erythroid maturation.Promoters of the murine embryonic beta-like globin genes Ey and betah1 do not compete for interaction with the beta-globin locus control region.Beta-globin locus control region HS2 and HS3 interact structurally and functionallyFurther understanding of the beta-globin locus regulation at the molecular level: looping or linking models?Human beta-globin locus control region HS5 contains CTCF- and developmental stage-dependent enhancer-blocking activity in erythroid cells.Regulation of Gγ-globin gene by ATF2 and its associated proteins through the cAMP-response element.The beta-globin promoter is important for recruitment of erythroid Krüppel-like factor to the locus control region in erythroid cellsDeletion of the core region of 5' HS2 of the mouse beta-globin locus control region reveals a distinct effect in comparison with human beta-globin transgenesThe hypersensitive sites of the murine β-globin locus control region act independently to affect nuclear localization and transcriptional elongation.A facilitated tracking and transcription mechanism of long-range enhancer function.LCR 5' hypersensitive site specificity for globin gene activation within the active chromatin hub.Recruitment of transcription complexes to the beta-globin gene locus in vivo and in vitroTranscriptional mechanisms underlying hemoglobin synthesis.Current status of globin gene therapy for the treatment of beta-thalassaemia.A spectrum of gene regulatory phenomena at mammalian beta-globin gene loci.Reconstitution of human beta-globin locus control region hypersensitive sites in the absence of chromatin assembly.Nuclear matrix association of the human beta-globin locus utilizing a novel approach to quantitative real-time PCRCharacteristics of the adeno-associated virus preintegration site in human chromosome 19: open chromatin conformation and transcription-competent environment.The polyoma virus enhancer cannot substitute for DNase I core hypersensitive sites 2-4 in the human beta-globin LCR.The higher structure of chromatin in the LCR of the beta-globin locus changes during development.HS5 of the human beta-globin locus control region: a developmental stage-specific border in erythroid cells.Recruitment of coregulator complexes to the beta-globin gene locus by TFII-I and upstream stimulatory factor.Embryonic and fetal beta-globin gene repression by the orphan nuclear receptors, TR2 and TR4.Deletion of the human beta-globin LCR 5'HS4 or 5'HS1 differentially affects beta-like globin gene expression in beta-YAC transgenic mice.Cooperativeness of the higher chromatin structure of the beta-globin locus revealed by the deletion mutations of DNase I hypersensitive site 3 of the LCR.Differential requirement of a distal regulatory region for pre-initiation complex formation at globin gene promoters.Hb S/β+-thalassemia due to Hb sickle and a novel deletion of DNase I hypersensitive sites HS3 and HS4 of the β locus control region.Evidence for a bigenic chromatin subdomain in regulation of the fetal-to-adult hemoglobin switch.HS2 enhancer function is blocked by a transcriptional terminator inserted between the enhancer and the promoter.Locus control region elements HS2 and HS3 in combination with chromatin boundaries confer high-level expression of a human beta-globin transgene in a centromeric region.Expression of green fluorescent protein under the regulation of human locus control region elements HS2 and HS3 in transgenic mice.
P2860
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P2860
Hypersensitive site 2 specifies a unique function within the human beta-globin locus control region to stimulate globin gene transcription.
description
1999 nî lūn-bûn
@nan
1999 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Hypersensitive site 2 specifie ...... ate globin gene transcription.
@ast
Hypersensitive site 2 specifie ...... ate globin gene transcription.
@en
type
label
Hypersensitive site 2 specifie ...... ate globin gene transcription.
@ast
Hypersensitive site 2 specifie ...... ate globin gene transcription.
@en
prefLabel
Hypersensitive site 2 specifie ...... ate globin gene transcription.
@ast
Hypersensitive site 2 specifie ...... ate globin gene transcription.
@en
P2093
P2860
P356
P1476
Hypersensitive site 2 specifie ...... ate globin gene transcription.
@en
P2093
P2860
P304
P356
10.1128/MCB.19.4.3062
P407
P577
1999-04-01T00:00:00Z