Detailed analysis of the site 3 region of the human beta-globin dominant control region
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Purification of the human NF-E2 complex: cDNA cloning of the hematopoietic cell-specific subunit and evidence for an associated partnerCloning of Nrf1, an NF-E2-related transcription factor, by genetic selection in yeastSmall Maf proteins interact with the human transcription factor TCF11/Nrf1/LCR-F1Cloning and functional characterization of LCR-F1: a bZIP transcription factor that activates erythroid-specific, human globin gene expressionIsolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control regionA novel, erythroid cell-specific murine transcription factor that binds to the CACCC element and is related to the Krüppel family of nuclear proteinsIn vivo footprinting of the human alpha-globin locus upstream regulatory element by guanine and adenine ligation-mediated polymerase chain reactionThe ubiquitous subunit of erythroid transcription factor NF-E2 is a small basic-leucine zipper protein related to the v-maf oncogenep45(NFE2) is a negative regulator of erythroid proliferation which contributes to the progression of Friend virus-induced erythroleukemiasComplexity of the erythroid transcription factor NF-E2 as revealed by gene targeting of the mouse p18 NF-E2 locusNF-E2 disrupts chromatin structure at human beta-globin locus control region hypersensitive site 2 in vitroEffect of deletion of 5'HS3 or 5'HS2 of the human beta-globin locus control region on the developmental regulation of globin gene expression in beta-globin locus yeast artificial chromosome transgenic mice.Mutation of a transcriptional motif of a distant regulatory element reduces the expression of embryonic and fetal globin genes.Requirements for utilization of CREB binding protein by hypersensitive site two of the beta-globin locus control regionIn vivo protein-DNA interactions at hypersensitive site 3 of the human beta-globin locus control region.Pathological interactions between hematopoietic stem cells and their niche revealed by mouse models of primary myelofibrosis.Developmental specificity of the interaction between the locus control region and embryonic or fetal globin genes in transgenic mice with an HS3 core deletionConservation of the primary structure, organization, and function of the human and mouse beta-globin locus-activating regions.Beta-globin locus activation regions: conservation of organization, structure, and functionSynergistic enhancement of globin gene expression by activator protein-1-like proteins.Evaluation of regulatory potential and conservation scores for detecting cis-regulatory modules in aligned mammalian genome sequences.Erythropoiesis and globin gene expression in mice lacking the transcription factor NF-E2The beta-globin dominant control region: hypersensitive site 2Synergistic and additive properties of the beta-globin locus control region (LCR) revealed by 5'HS3 deletion mutations: implication for LCR chromatin architecture.Erythroid-specific activity of the glycophorin B promoter requires GATA-1 mediated displacement of a repressorAnalysis of the human alpha globin upstream regulatory element (HS-40) in transgenic miceAnalysis of mice with single and multiple copies of transgenes reveals a novel arrangement for the lambda5-VpreB1 locus control region.Hypersensitive site 2 specifies a unique function within the human beta-globin locus control region to stimulate globin gene transcription.Enhancement of beta-globin locus control region-mediated transactivation by mitogen-activated protein kinases through stochastic and graded mechanismsStructural and functional cross-talk between a distant enhancer and the epsilon-globin gene promoter shows interdependence of the two elements in chromatin.Sequences flanking hypersensitive sites of the beta-globin locus control region are required for synergistic enhancementSynthetic human beta-globin 5'HS2 constructs function as locus control regions only in multicopy transgene concatamers.The minimal requirements for activity in transgenic mice of hypersensitive site 3 of the beta globin locus control region.Conditional expression of the ubiquitous transcription factor MafK induces erythroleukemia cell differentiation.The two zinc finger-like domains of GATA-1 have different DNA binding specificitiesGeneration of a high-titer retroviral vector capable of expressing high levels of the human beta-globin gene.Multiple interactions between regulatory regions are required to stabilize an active chromatin hub.Retroviral transfer of a human beta-globin/delta-globin hybrid gene linked to beta locus control region hypersensitive site 2 aimed at the gene therapy of sickle cell disease.An Erythroid-Specific Chromatin Opening Element Increases β-Globin Gene Expression from Integrated Retroviral Gene Transfer Vectors.Evaluation of beta-globin gene therapy constructs in single copy transgenic mice.
P2860
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P2860
Detailed analysis of the site 3 region of the human beta-globin dominant control region
description
1990 nî lūn-bûn
@nan
1990 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
1990 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
1990年の論文
@ja
1990年論文
@yue
1990年論文
@zh-hant
1990年論文
@zh-hk
1990年論文
@zh-mo
1990年論文
@zh-tw
1990年论文
@wuu
name
Detailed analysis of the site 3 region of the human beta-globin dominant control region
@ast
Detailed analysis of the site 3 region of the human beta-globin dominant control region
@en
type
label
Detailed analysis of the site 3 region of the human beta-globin dominant control region
@ast
Detailed analysis of the site 3 region of the human beta-globin dominant control region
@en
prefLabel
Detailed analysis of the site 3 region of the human beta-globin dominant control region
@ast
Detailed analysis of the site 3 region of the human beta-globin dominant control region
@en
P2093
P2860
P1433
P1476
Detailed analysis of the site 3 region of the human beta-globin dominant control region
@en
P2093
P2860
P304
P356
10.1002/J.1460-2075.1990.TB07386.X
P407
P577
1990-07-01T00:00:00Z