An erythroid-specific, developmental-stage-independent enhancer far upstream of the human "beta-like globin" genes.
about
Defining functional DNA elements in the human genomeIntestinal apolipoprotein AI gene transcription is regulated by multiple distinct DNA elements and is synergistically activated by the orphan nuclear receptor, hepatocyte nuclear factor 4Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control regionBach proteins belong to a novel family of BTB-basic leucine zipper transcription factors that interact with MafK and regulate transcription through the NF-E2 sitehMAF, a small human transcription factor that heterodimerizes specifically with Nrf1 and Nrf2NF-E2 disrupts chromatin structure at human beta-globin locus control region hypersensitive site 2 in vitroA negative cis-element regulates the level of enhancement by hypersensitive site 2 of the beta-globin locus control region.Identification and characterization of cell type-specific and ubiquitous chromatin regulatory structures in the human genome.5'HS5 of the human beta-globin locus control region is dispensable for the formation of the beta-globin active chromatin hub.Function-based identification of mammalian enhancers using site-specific integration.Requirements for utilization of CREB binding protein by hypersensitive site two of the beta-globin locus control regionThe role of trans-acting factors and DNA-bending in the silencing of human beta-globin gene expression.The locus control region is necessary for gene expression in the human beta-globin locus but not the maintenance of an open chromatin structure in erythroid cells.Substitution of the human beta-spectrin promoter for the human agamma-globin promoter prevents silencing of a linked human beta-globin gene in transgenic miceDNase I hypersensitivity and epsilon-globin transcriptional enhancement are separable in locus control region (LCR) HS1 mutant human beta-globin YAC transgenic miceConservation of the primary structure, organization, and function of the human and mouse beta-globin locus-activating regions.Adjacent DNA elements dominantly restrict the ubiquitous activity of a novel chromatin-opening region to specific tissues.Divergence in cis-regulatory sequences surrounding the opsin gene arrays of African cichlid fishes.Synergistic enhancement of globin gene expression by activator protein-1-like proteins.Evaluation of regulatory potential and conservation scores for detecting cis-regulatory modules in aligned mammalian genome sequences.Definition of the minimal requirements within the human beta-globin gene and the dominant control region for high level expression.The beta-globin dominant control region: hypersensitive site 2Detailed analysis of the site 3 region of the human beta-globin dominant control regionSynergistic and additive properties of the beta-globin locus control region (LCR) revealed by 5'HS3 deletion mutations: implication for LCR chromatin architecture.Identification of a stage selector element in the human gamma-globin gene promoter that fosters preferential interaction with the 5' HS2 enhancer when in competition with the beta-promoter.Analysis of the human alpha globin upstream regulatory element (HS-40) in transgenic miceA new element within the T-cell receptor alpha locus required for tissue-specific locus control region activityHypersensitive site 2 specifies a unique function within the human beta-globin locus control region to stimulate globin gene transcription.Structural and functional cross-talk between a distant enhancer and the epsilon-globin gene promoter shows interdependence of the two elements in chromatin.Evolution of hemoglobin and its genesSp1 functions in a chromatin-dependent manner to augment human alpha-globin promoter activity.Synthetic human beta-globin 5'HS2 constructs function as locus control regions only in multicopy transgene concatamers.The minimal requirements for activity in transgenic mice of hypersensitive site 3 of the beta globin locus control region.The beta-globin locus control region versus gene therapy vectors: a struggle for expression.Molecular analysis of the human beta-globin locus activation region.Human beta-globin gene expression in transgenic mice is enhanced by a distant DNase I hypersensitive siteGamma delta beta-thalassemia due to a de novo mutation deleting the 5' beta-globin gene activation-region hypersensitive sites.Localization and characterization of the DNase I-hypersensitive site II (HS II) enhancer. A critical regulatory element within the beta-globin locus-activating region.Permanent and panerythroid correction of murine beta thalassemia by multiple lentiviral integration in hematopoietic stem cells.Retroviral transfer of a human beta-globin/delta-globin hybrid gene linked to beta locus control region hypersensitive site 2 aimed at the gene therapy of sickle cell disease.
P2860
Q22066251-91707158-CB78-42CD-BF0C-3916F947A8A7Q24318945-6DB0394B-9ED8-4627-B548-7FC3D1755BF0Q24563505-4CD5BE17-93E3-4F9D-A241-AAFC9AFBCC34Q24647985-2C294138-B7D3-45D7-8F29-62B5004C5EDCQ28241711-C102C40C-CEF4-45B3-877F-D0D805E90F89Q28610614-15BCA817-C3B7-48D1-8ED5-BB741F3F72FCQ31621466-1EC03B04-3CF7-4C31-AE4A-5B3DF03496BDQ33294656-1FD36B80-3C55-4B3E-B133-703E9D460CC9Q33332161-2AEE9FB6-1536-4DDD-8B58-5BC5EB202E52Q33559746-65DEE486-CD34-4092-8753-84C23A80DD32Q33600935-B96DED18-9EE7-4FCC-B673-D987F1CCD543Q33616959-C520028A-0833-4CFF-AF18-BB7C9D3441DBQ33780942-CE1DBE71-5975-407D-A6D0-4D839CEB6866Q33781540-96A6A2A6-96F3-44A0-9F62-03CD3C271652Q33825041-DBAFA5BE-51A4-42D6-8BB8-A47966995925Q33826188-5827CAC8-B51B-4DA9-B9C4-965A924C6789Q33887308-5B025254-FAC3-42A9-91E6-C26ABE4514C7Q33893358-774136CD-3605-46B6-B162-78DFC1D3FA92Q33901560-5804B5D1-EB04-448F-9489-E06082AA4E88Q33910867-977A3A10-F07F-454B-AA6D-FE9607D33BE2Q33917150-BC428B9F-D3C5-4232-AEF8-0466740C77ECQ33920685-48BE64FC-5923-4C0C-B541-6D9EFA117C6DQ33920690-12089AF2-ED17-4499-8837-8EEC03218B92Q33924906-1558AC46-C1FF-4CFD-BEB4-EA2A209F7F48Q33938186-88D05C5C-D8CA-4A46-B377-CE44708961F9Q33938795-780E4A24-B68B-4B77-994F-093120EF7F82Q33957415-C2869585-43C3-4BE3-B9A4-D10CF603D468Q33957790-DA0B9F69-8B3E-4FC2-A65D-79A31FFBD714Q33960162-1790385E-09E1-469C-954A-3624FC260402Q34034627-5329A87D-F516-48A6-BDE4-40C4AFE87084Q34039291-8702F920-5852-4244-82B5-FD7D61610FD3Q34040808-8E8EEFE7-1EFB-4E78-A5F8-FE2AC2DE292AQ34046036-89C26768-C22D-478F-A37E-2C465907F8A7Q34135439-8EA8E55B-6097-41E2-9FA2-2D9202E74AD6Q34290946-375EB2BF-1B56-451E-B032-FA23536B2548Q34304020-2366D98B-B615-48C4-9FCC-C101A8BBDE81Q34307556-465E882D-2067-4F3F-89D4-151AFD91079DQ34390353-5A4FE1E8-7032-4F93-A5D9-7104891E0A14Q34393866-3A5F216B-F3FA-4590-B760-C17527F6E11EQ34528437-BB805DD3-62EB-4B96-A0A1-C842A0DD375D
P2860
An erythroid-specific, developmental-stage-independent enhancer far upstream of the human "beta-like globin" genes.
description
1989 nî lūn-bûn
@nan
1989 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
1989 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
1989年の論文
@ja
1989年論文
@yue
1989年論文
@zh-hant
1989年論文
@zh-hk
1989年論文
@zh-mo
1989年論文
@zh-tw
1989年论文
@wuu
name
An erythroid-specific, develop ...... uman "beta-like globin" genes.
@ast
An erythroid-specific, develop ...... uman "beta-like globin" genes.
@en
type
label
An erythroid-specific, develop ...... uman "beta-like globin" genes.
@ast
An erythroid-specific, develop ...... uman "beta-like globin" genes.
@en
prefLabel
An erythroid-specific, develop ...... uman "beta-like globin" genes.
@ast
An erythroid-specific, develop ...... uman "beta-like globin" genes.
@en
P2093
P2860
P356
P1476
An erythroid-specific, develop ...... uman "beta-like globin" genes.
@en
P2093
P2860
P304
P356
10.1073/PNAS.86.8.2554
P407
P577
1989-04-01T00:00:00Z