Terminally differentiated human neurons repair transcribed genes but display attenuated global DNA repair and modulation of repair gene expression.
about
Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivoTargeted DNA mutagenesis for the cure of chronic viral infectionsImpaired nucleotide excision repair upon macrophage differentiation is corrected by E1 ubiquitin-activating enzymeIncreased apoptosis, p53 up-regulation, and cerebellar neuronal degeneration in repair-deficient Cockayne syndrome miceGenome Engineering with TALE and CRISPR Systems in NeuroscienceThe Response to Oxidative DNA Damage in Neurons: Mechanisms and DiseaseDifferentiation driven changes in the dynamic organization of Basal transcription initiationInvolvement of global genome repair, transcription coupled repair, and chromatin remodeling in UV DNA damage response changes during developmentBalancing self-renewal against genome preservation in stem cells: How do they manage to have the cake and eat it too?Early transcriptional response to aminoglycoside antibiotic suggests alternate pathways leading to apoptosis in sensory hair cells in the mouse inner earEarly postnatal ataxia and abnormal cerebellar development in mice lacking Xeroderma pigmentosum Group A and Cockayne syndrome Group B DNA repair genesClusters of transcription-coupled repair in the human genome.Highly conserved regimes of neighbor-base-dependent mutation generated the background primary-structural heterogeneities along vertebrate chromosomes.Telomeres and disease.Large-scale expression analysis reveals distinct microRNA profiles at different stages of human neurodevelopment.Effects of obesogenic diet and estradiol on dorsal raphe gene expression in old female macaquesMechanisms and consequences of aneuploidy and chromosome instability in the aging brainOxidative stress triggers the preferential assembly of base excision repair complexes on open chromatin regionsDNA repair proteins affect the lifecycle of herpes simplex virus 1.Evidence that herpes simplex virus DNA derived from quiescently infected cells in vitro, and latently infected cells in vivo, is physically damagedDNA repair deficiency in neurodegeneration.Abrupt onset of mutations in a developmentally regulated gene during terminal differentiation of post-mitotic photoreceptor neurons in mice.Ischemic injury and faulty gene transcripts in the brainPathway reporter genes define molecular phenotypes of human cellsBlinded by the UV light: how the focus on transcription-coupled NER has distracted from understanding the mechanisms of Cockayne syndrome neurologic diseaseTranscription restores DNA repair to heterochromatin, determining regional mutation rates in cancer genomes.DNA repair mechanisms in dividing and non-dividing cells.Transcription domain-associated repair in human cells.Regulation of nucleotide excision repair in bacteria and mammalian cells.Long-term ovariectomy decreases serotonin neuron number and gene expression in free ranging macaques.Ovarian steroids regulate gene expression related to DNA repair and neurodegenerative diseases in serotonin neurons of macaques.Direct evidence that HSV DNA damaged by ultraviolet (UV) irradiation can be repaired in a cell type-dependent manner.CUX2 protein functions as an accessory factor in the repair of oxidative DNA damage.Terminally differentiated muscle cells are defective in base excision DNA repair and hypersensitive to oxygen injury.Accumulation of oxidatively generated DNA damage in the brain: a mechanism of neurotoxicity.Photobiological Origins of the Field of Genomic Maintenance.Synaptic dysfunction and oxidative stress in Alzheimer's disease: emerging mechanisms.DNA damage promotes herpes simplex virus-1 protein expression in a neuroblastoma cell line.The oxidatively induced DNA lesions 8,5'-cyclo-2'-deoxyadenosine and 8-hydroxy-2'-deoxyadenosine are strongly resistant to acid-induced hydrolysis of the glycosidic bondClinical implications of the basic defects in Cockayne syndrome and xeroderma pigmentosum and the DNA lesions responsible for cancer, neurodegeneration and aging
P2860
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P2860
Terminally differentiated human neurons repair transcribed genes but display attenuated global DNA repair and modulation of repair gene expression.
description
2000 nî lūn-bûn
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2000年の論文
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name
Terminally differentiated huma ...... ion of repair gene expression.
@ast
Terminally differentiated huma ...... ion of repair gene expression.
@en
type
label
Terminally differentiated huma ...... ion of repair gene expression.
@ast
Terminally differentiated huma ...... ion of repair gene expression.
@en
prefLabel
Terminally differentiated huma ...... ion of repair gene expression.
@ast
Terminally differentiated huma ...... ion of repair gene expression.
@en
P2860
P1476
Terminally differentiated huma ...... ion of repair gene expression.
@en
P2093
P C Hanawalt
T Nouspikel
P2860
P304
P356
10.1128/MCB.20.5.1562-1570.2000
P407
P577
2000-03-01T00:00:00Z