Identification of a small molecule inhibitor of the hedgehog signaling pathway: effects on basal cell carcinoma-like lesions. - Wikidata - wikimedia - TriplyDB

Identification of a small molecule inhibitor of the hedgehog signaling pathway: effects on basal cell carcinoma-like lesions.

Identification of a small molecule inhibitor of the hedgehog signaling pathway: effects on basal cell carcinoma-like lesions.

http://www.wikidata.org/entity/Q33965304

about

NVP-LDE225, a potent and selective SMOOTHENED antagonist reduces melanoma growth in vitro and in vivo Oxysterols stimulate Sonic hedgehog signal transduction and proliferation of medulloblastoma cells Arsenic antagonizes the Hedgehog pathway by preventing ciliary accumulation and reducing stability of the Gli2 transcriptional effector A small molecule that binds Hedgehog and blocks its signaling in human cells Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists Agonizing hedgehog.Roughing up Smoothened: chemical modulators of hedgehog signaling The therapeutic potential of modulators of the Hedgehog-Gli signaling pathway Targeting the Sonic Hedgehog Signaling Pathway: Review of Smoothened and GLI Inhibitors The Role of Hedgehog Signaling in Tumor Induced Bone Disease Hedgehog Signaling in the Maintenance of Cancer Stem Cells Cooperative integration between HEDGEHOG-GLI signalling and other oncogenic pathways: implications for cancer therapy Basal cell carcinoma - molecular biology and potential new therapies Hedgehog signaling pathway and its targets for treatment in basal cell carcinoma Novel small molecules targeting ciliary transport of Smoothened and oncogenic Hedgehog pathway activation.Molecular pathways: novel approaches for improved therapeutic targeting of Hedgehog signaling in cancer stem cells Arsenic trioxide prevents osteosarcoma growth by inhibition of GLI transcription via DNA damage accumulation Hedgehog signaling is critical for maintenance of the adult coronary vasculature in mice Targeting GLI1 expression in human inflammatory breast cancer cells enhances apoptosis and attenuates migration.Stem cell biology and drug discovery.Indian hedgehog signaling pathway: expression and regulation in pancreatic cancer.Gli-1 siRNA induced apoptosis in Huh7 cells.Converse conformational control of smoothened activity by structurally related small molecules.Recent patents for Hedgehog pathway inhibitors for the treatment of malignancy.Identification of Hedgehog signaling inhibitors with relevant human exposure by small molecule screening.Effects of inhibition of hedgehog signaling on cell growth and migration of uveal melanoma cells.Sustained Hedgehog signaling is required for basal cell carcinoma proliferation and survival: conditional skin tumorigenesis recapitulates the hair growth cycle New hedgehog/GLI-signaling inhibitors from Adenium obesum.Targeting superficial or nodular Basal cell carcinoma with topically formulated small molecule inhibitor of smoothened Targeting Hedgehog--a cancer stem cell pathway Recent advances on skin-resident stem/progenitor cell functions in skin regeneration, aging and cancers and novel anti-aging and cancer therapies.Computational analysis of expression of human embryonic stem cell-associated signatures in tumors.Cleft lip and palate results from Hedgehog signaling antagonism in the mouse: Phenotypic characterization and clinical implications Dose- and route-dependent teratogenicity, toxicity, and pharmacokinetic profiles of the hedgehog signaling antagonist cyclopamine in the mouse.Small-molecule modulators of the Sonic Hedgehog signaling pathway.Functional diversity of ESC-derived motor neuron subtypes revealed through intraspinal transplantation.Frequent deregulations in the hedgehog signaling network and cross-talks with the epidermal growth factor receptor pathway involved in cancer progression and targeted therapies.Hedgehog and spinal cord injury.Bone morphogenetic protein antagonist gremlin 1 is widely expressed by cancer-associated stromal cells and can promote tumor cell proliferation.Hedgehog activity controls opening of the primary mouth.

P2860

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P2860

Identification of a small molecule inhibitor of the hedgehog signaling pathway: effects on basal cell carcinoma-like lesions.

http://www.wikidata.org/entity/Q33965304

description

2003 nî lūn-bûn

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2003 թուականի Ապրիլին հրատարակուած գիտական յօդուած

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2003 թվականի ապրիլին հրատարակված գիտական հոդված

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2003年の論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年论文

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Identification of a small mole ...... l cell carcinoma-like lesions.

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Identification of a small mole ...... l cell carcinoma-like lesions.

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Identification of a small mole ...... l cell carcinoma-like lesions.

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Identification of a small mole ...... l cell carcinoma-like lesions.

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Identification of a small mole ...... l cell carcinoma-like lesions.

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Identification of a small mole ...... l cell carcinoma-like lesions.

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Identification of a small mole ...... al cell carcinoma-like lesions

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Beatrice I Zaharian

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Charlene Kon

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Christine Gatchalian

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Frank Y Wang

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Hynek Wichterle

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Jeffery A Porter

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Juliet A Williams

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Ling Chai

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Oivin M Guicherit

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Yin Xu

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P2860

Activating Smoothened mutations in sporadic basal-cell carcinoma

Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome

Small molecule modulation of Smoothened activity

Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation

Induction of basal cell carcinomas and trichoepitheliomas in mice overexpressing GLI-1

Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened

Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists

Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine

The Hedgehog and Wnt signalling pathways in cancer

Hedgehog signaling in animal development: paradigms and principles

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