p53-dependent senescence delays Emu-myc-induced B-cell lymphomagenesis.
about
p53-mediated senescence impairs the apoptotic response to chemotherapy and clinical outcome in breast cancer.Separase loss of function cooperates with the loss of p53 in the initiation and progression of T- and B-cell lymphoma, leukemia and aneuploidy in miceAberrant anaplastic lymphoma kinase activity induces a p53 and Rb-dependent senescence-like arrest in the absence of detectable p53 stabilizationMitotic chromosome condensation mediated by the retinoblastoma protein is tumor-suppressiveDevelopments in Burkitt's lymphoma: novel cooperations in oncogenic MYC signaling.A high-frequency regulatory polymorphism in the p53 pathway accelerates tumor development.The codon 72 polymorphism of p53 regulates interaction with NF-{kappa}B and transactivation of genes involved in immunity and inflammationApoptosis is the essential target of selective pressure against p53, whereas loss of additional p53 functions facilitates carcinoma progression.Depletion of the histone chaperone tNASP inhibits proliferation and induces apoptosis in prostate cancer PC-3 cells.Tissue-specific apoptotic effects of the p53 codon 72 polymorphism in a mouse model.Mutant p53 disrupts role of ShcA protein in balancing Smad protein-dependent and -independent signaling activity of transforming growth factor-β (TGF-β).Novel ARF/p53-independent senescence pathways in cancer repression.Dysfunction of the TP53 tumor suppressor gene in lymphoid malignancies.Cell cycle- and DNA repair pathway-specific effects of apoptosis on tumor suppression.Expression and activity of eIF6 trigger malignant pleural mesothelioma growth in vivo.Senescence sensitivity of breast cancer cells is defined by positive feedback loop between CIP2A and E2F1.The ATM signaling network in development and disease.E6AP ubiquitin ligase regulates PML-induced senescence in Myc-driven lymphomagenesis.Phosphorylation of the Mdm2 oncoprotein by the c-Abl tyrosine kinase regulates p53 tumor suppression and the radiosensitivity of mice.Multi-focal control of mitochondrial gene expression by oncogenic MYC provides potential therapeutic targets in cancer.Two sides of the Myc-induced DNA damage response: from tumor suppression to tumor maintenance.Unravelling mechanisms of p53-mediated tumour suppression.The Cell-Cycle Arrest and Apoptotic Functions of p53 in Tumor Initiation and Progression.The Regulation of Cellular Functions by the p53 Protein: Cellular Senescence.Regulation of the Mdm2-p53 signaling axis in the DNA damage response and tumorigenesis.The ups and downs of p53 regulation in hematopoietic stem cells.Multiple stress signals activate mutant p53 in vivo.Mantle cell lymphoma-like lymphomas in c-myc-3'RR/p53+/- mice and c-myc-3'RR/Cdk4R24C mice: differential oncogenic mechanisms but similar cellular origin.Mdm2 is required for survival of hematopoietic stem cells/progenitors via dampening of ROS-induced p53 activityMYC-driven tumorigenesis is inhibited by WRN syndrome gene deficiency.Mnt modulates Myc-driven lymphomagenesis.Combined loss of PUMA and p21 accelerates c-MYC-driven lymphoma development considerably less than loss of one allele of p53.Deconstructing networks of p53-mediated tumor suppression in vivo.
P2860
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P2860
p53-dependent senescence delays Emu-myc-induced B-cell lymphomagenesis.
description
2009 nî lūn-bûn
@nan
2009 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
p53-dependent senescence delays Emu-myc-induced B-cell lymphomagenesis.
@ast
p53-dependent senescence delays Emu-myc-induced B-cell lymphomagenesis.
@en
type
label
p53-dependent senescence delays Emu-myc-induced B-cell lymphomagenesis.
@ast
p53-dependent senescence delays Emu-myc-induced B-cell lymphomagenesis.
@en
prefLabel
p53-dependent senescence delays Emu-myc-induced B-cell lymphomagenesis.
@ast
p53-dependent senescence delays Emu-myc-induced B-cell lymphomagenesis.
@en
P2093
P2860
P356
P1433
P1476
p53-dependent senescence delays Emu-myc-induced B-cell lymphomagenesis.
@en
P2093
A Quintás-Cardama
C M Eischen
P2860
P2888
P304
P356
10.1038/ONC.2009.423
P407
P577
2009-11-23T00:00:00Z
P5875
P6179
1052312262