Mdm2 is required for survival of hematopoietic stem cells/progenitors via dampening of ROS-induced p53 activity - Wikidata - wikimedia - TriplyDB

Mdm2 is required for survival of hematopoietic stem cells/progenitors via dampening of ROS-induced p53 activity

Mdm2 is required for survival of hematopoietic stem cells/progenitors via dampening of ROS-induced p53 activity

http://www.wikidata.org/entity/Q42579780

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Oxidative stress, bone marrow failure, and genome instability in hematopoietic stem cells To breathe or not to breathe: the haematopoietic stem/progenitor cells dilemma Reactive oxygen species in cancer stem cells Redox regulation of stem/progenitor cells and bone marrow niche Reactive oxygen species adversely impacts bone marrow microenvironment in diabetes Roles of FGF signaling in stem cell self-renewal, senescence and aging Emerging Non-Canonical Functions and Regulation by p53: p53 and Stemness Redox homeostasis: the linchpin in stem cell self-renewal and differentiation The C terminus of p53 regulates gene expression by multiple mechanisms in a target- and tissue-specific manner in vivo Cadmium-Induced Pathologies: Where Is the Oxidative Balance Lost (or Not)?Therapeutic inducers of the HSP70/HSP110 protect mice against traumatic brain injury Regulation of stem-like cancer cells by glutamine through β-catenin pathway mediated by redox signaling.ROS-mediated platelet generation: a microenvironment-dependent manner for megakaryocyte proliferation, differentiation, and maturation.Total body irradiation causes long-term mouse BM injury via induction of HSC premature senescence in an Ink4a- and Arf-independent manner.Novel roles of reactive oxygen species in the pathogenesis of acute myeloid leukemia.Postexercise essential amino acid supplementation amplifies skeletal muscle satellite cell proliferation in older men 24 hours postexercise Regulation of high-density lipoprotein on hematopoietic stem/progenitor cells in atherosclerosis requires scavenger receptor type BI expression.Tissue-specific and age-dependent effects of global Mdm2 loss Ribosomal protein S27-like is a physiological regulator of p53 that suppresses genomic instability and tumorigenesis Validation of MdmX as a therapeutic target for reactivating p53 in tumors Reactive oxygen species in normal and tumor stem cells.Stem cells and the impact of ROS signaling.Hematopoietic stem cell quiescence and function are controlled by the CYLD-TRAF2-p38MAPK pathway.Accelerated hematopoietic stem cell aging in a mouse model of dyskeratosis congenita responds to antioxidant treatment.The redox-sensitive transcription factor Nrf2 regulates murine hematopoietic stem cell survival independently of ROS levels.Dysfunction of the TP53 tumor suppressor gene in lymphoid malignancies.Microvesicles from Mesenchymal Stromal Cells Are Involved in HPC-Microenvironment Crosstalk in Myelodysplastic Patients.Reactive oxygen species and hematopoietic stem cell senescence.Gene and protein analysis reveals that p53 pathway is functionally inactivated in cytogenetically normal Acute Myeloid Leukemia and Acute Promyelocytic Leukemia The p53 pathway in hematopoiesis: lessons from mouse models, implications for humans.Cell autonomous and nonautonomous mechanisms drive hematopoietic stem/progenitor cell loss in the absence of DNA repair.Regulation of hematopoietic stem cell fate by the ubiquitin proteasome system Protective Effect of Ginsenoside Rg1 on Hematopoietic Stem/Progenitor Cells through Attenuating Oxidative Stress and the Wnt/β-Catenin Signaling Pathway in a Mouse Model of d-Galactose-induced Aging The p53-Mdm2 feedback loop protects against DNA damage by inhibiting p53 activity but is dispensable for p53 stability, development, and longevity BRPF1 is essential for development of fetal hematopoietic stem cells Genetic control of quiescence in hematopoietic stem cells.Hyperactivation of mammalian target of rapamycin complex 1 (mTORC1) promotes breast cancer progression through enhancing glucose starvation-induced autophagy and Akt signaling.Hematopoietic stem cell injury induced by ionizing radiation.Hematopoietic stem cell senescence and cancer therapy-induced long-term bone marrow injury.Stem cells, redox signaling, and stem cell aging.

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Mdm2 is required for survival of hematopoietic stem cells/progenitors via dampening of ROS-induced p53 activity

http://www.wikidata.org/entity/Q42579780

description

2010 nî lūn-bûn

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

Mdm2 is required for survival ...... ng of ROS-induced p53 activity

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Mdm2 is required for survival ...... ng of ROS-induced p53 activity

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type

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Mdm2 is required for survival ...... ng of ROS-induced p53 activity

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Mdm2 is required for survival ...... ng of ROS-induced p53 activity

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Mdm2 is required for survival ...... ng of ROS-induced p53 activity

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Mdm2 is required for survival ...... ng of ROS-induced p53 activity

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J.STEM.2010.09.013

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P1476

Mdm2 is required for survival ...... ng of ROS-induced p53 activity

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Amy L Hazen

http://www.w3.org/2001/XMLSchema#string

Daniela R Maccio

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Guillermina Lozano

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Hussein A Abbas

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Karen K Hirschi

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M James You

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Suleyman Coskun

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Tiffany M Sills

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P2860

A model for p53-induced apoptosis

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

The genetics of the p53 pathway, apoptosis and cancer therapy.

Proline oxidase, encoded by p53-induced gene-6, catalyzes the generation of proline-dependent reactive oxygen species

Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells

Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells

Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

p53: puzzle and paradigm

Hematopoiesis: an evolving paradigm for stem cell biology

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606-617

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scholarly article

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10.1016/J.STEM.2010.09.013

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5

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7

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James G Jackson

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2010-11-01T00:00:00Z

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47644198

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21040902

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3026610

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