Identification of novel substrates for the serine protease HTRA1 in the human RPE secretome - Wikidata - wikimedia - TriplyDB

Identification of novel substrates for the serine protease HTRA1 in the human RPE secretome

Identification of novel substrates for the serine protease HTRA1 in the human RPE secretome

http://www.wikidata.org/entity/Q33994138

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Complement in age-related macular degeneration: a focus on function Alpha-1-antitrypsin: a novel human high temperature requirement protease A1 (HTRA1) substrate in human placental tissue Overexpression of HTRA1 leads to ultrastructural changes in the elastic layer of Bruch's membrane via cleavage of extracellular matrix components Heritability and genome-wide association study to assess genetic differences between advanced age-related macular degeneration subtypes Specific correlation between the major chromosome 10q26 haplotype conferring risk for age-related macular degeneration and the expression of HTRA1 Characterisation of the vitreous proteome in proliferative diabetic retinopathy.Complement system in pathogenesis of AMD: dual player in degeneration and protection of retinal tissue.Characterization of functional reprogramming during osteoclast development using quantitative proteomics and mRNA profiling.Effect of the Gas6 c.834+7G>A polymorphism and the interaction of known risk factors on AMD pathogenesis in Hungarian patients Genetics of age-related macular degeneration: current concepts, future directions.Cerebral small vessel disease-related protease HtrA1 processes latent TGF-β binding protein 1 and facilitates TGF-β signaling Risk- and non-risk-associated variants at the 10q26 AMD locus influence ARMS2 mRNA expression but exclude pathogenic effects due to protein deficiency.Cell-deposited matrix improves retinal pigment epithelium survival on aged submacular human Bruch's membrane.Increased expression of multifunctional serine protease, HTRA1, in retinal pigment epithelium induces polypoidal choroidal vasculopathy in mice.Genetic insights into age-related macular degeneration: controversies addressing risk, causality, and therapeutics.Angiographic features of transgenic mice with increased expression of human serine protease HTRA1 in retinal pigment epithelium Secretome survey of human plexiform neurofibroma derived Schwann Cells reveals a secreted form of the RARRES1 protein.Advances in the proteomic investigation of the cell secretome.Common polymorphisms in angiogenesis.Perturbations of the cerebrovascular matrisome: A convergent mechanism in small vessel disease of the brain?The human secretome atlas initiative: implications in health and disease conditions.Stable isotope dilution mass spectrometry for membrane transporter quantitation.Repressed SIRT1/PGC-1α pathway and mitochondrial disintegration in iPSC-derived RPE disease model of age-related macular degeneration.Dysfunctional autophagy in RPE, a contributing factor in age-related macular degeneration.Genetic factors associated with age-related macular degeneration.Architecture and regulation of HtrA-family proteins involved in protein quality control and stress response.Mechanism of inflammation in age-related macular degeneration Differential Gene Expression in Age-Related Macular Degeneration Analytical platforms in vitreoretinal proteomics.Protective effects of an HTRA1 insertion-deletion variant against age-related macular degeneration in the Chinese populations.Inhibition of cell proliferation and migration after HTRA1 knockdown in retinal pigment epithelial cells.Overexpression of HTRA1 leads to down-regulation of fibronectin and functional changes in RF/6A cells and HUVECs.HtrA1 activation is driven by an allosteric mechanism of inter-monomer communication.Lipopolysaccharide increases the incidence of collagen-induced arthritis in mice through induction of protease HTRA-1 expression.Macrophage migration inhibitory factor (MIF) modulates trophic signaling through interaction with serine protease HTRA1.Nicotinamide Ameliorates Disease Phenotypes in a Human iPSC Model of Age-Related Macular Degeneration.Proteomics of Human Retinal Pigment Epithelium (RPE) Cells.

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P2860

Identification of novel substrates for the serine protease HTRA1 in the human RPE secretome

http://www.wikidata.org/entity/Q33994138

description

2010 nî lūn-bûn

@nan

2010 թուականի Մարտին հրատարակուած գիտական յօդուած

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2010 թվականի մարտին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

Identification of novel substr ...... RA1 in the human RPE secretome

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Identification of novel substr ...... RA1 in the human RPE secretome

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type

label

Identification of novel substr ...... RA1 in the human RPE secretome

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Identification of novel substr ...... RA1 in the human RPE secretome

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prefLabel

Identification of novel substr ...... RA1 in the human RPE secretome

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Identification of novel substr ...... RA1 in the human RPE secretome

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Investigative Ophthalmology & Visual Science

P1476

Identification of novel substr ...... RA1 in the human RPE secretome

@en

P2093

Eunkyung An

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Heather Gordish-Dressman

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Sung Kyu Park

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Supti Sen

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Yetrib Hathout

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P2860

Human HtrA, an evolutionarily conserved serine protease identified as a differentially expressed gene product in osteoarthritic cartilage

A secreted form of human ADAM9 has an alpha-secretase activity for APP

Age-related macular degeneration is associated with an unstable ARMS2 (LOC387715) mRNA

Implications of the serine protease HtrA1 in amyloid precursor protein processing

A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration

Susceptibility genes for age-related maculopathy on chromosome 10q26.

Complement factor H polymorphism in age-related macular degeneration

A variant of mitochondrial protein LOC387715/ARMS2, not HTRA1, is strongly associated with age-related macular degeneration

Stable isotope labeling by amino acids in cell culture, SILAC, as a simple and accurate approach to expression proteomics

The HtrA1 serine protease is down-regulated during human melanoma progression and represses growth of metastatic melanoma cells

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3379-3386

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scholarly article

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10.1167/IOVS.09-4853

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7

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51

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41808593

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20207970

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2904004

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