Inhibition of hypoxia-inducible factor (HIF) hydroxylases by citric acid cycle intermediates: possible links between cell metabolism and stabilization of HIF. - Wikidata - wikimedia - TriplyDB

Inhibition of hypoxia-inducible factor (HIF) hydroxylases by citric acid cycle intermediates: possible links between cell metabolism and stabilization of HIF.

Inhibition of hypoxia-inducible factor (HIF) hydroxylases by citric acid cycle intermediates: possible links between cell metabolism and stabilization of HIF.

http://www.wikidata.org/entity/Q34001546

about

The FH mutation database: an online database of fumarate hydratase mutations involved in the MCUL (HLRCC) tumor syndrome and congenital fumarase deficiency Pyruvate dehydrogenase complex activity controls metabolic and malignant phenotype in cancer cells Screening chelating inhibitors of HIF-prolyl hydroxylase domain 2 (PHD2) and factor inhibiting HIF (FIH)HIF-1: upstream and downstream of cancer metabolism Germline mutations and variants in the succinate dehydrogenase genes in Cowden and Cowden-like syndromes Mitochondria, cholesterol and cancer cell metabolism Hypoxia-Inducible Histone Lysine Demethylases: Impact on the Aging Process and Age-Related Diseases Mitochondria-controlled signaling mechanisms of brain protection in hypoxia Succinate Dehydrogenase Loss in Familial Paraganglioma: Biochemistry, Genetics, and Epigenetics Ascorbate as a co-factor for fe- and 2-oxoglutarate dependent dioxygenases: physiological activity in tumor growth and progression Nutrient sensing, metabolism, and cell growth control HIF1A reduces acute lung injury by optimizing carbohydrate metabolism in the alveolar epithelium Succinate dehydrogenase upregulation destabilize complex I and limits the lifespan of gas-1 mutant Insulin/IGF-1 and hypoxia signaling act in concert to regulate iron homeostasis in Caenorhabditis elegans Hepatitis C Virus-Linked Mitochondrial Dysfunction Promotes Hypoxia-Inducible Factor 1 -Mediated Glycolytic Adaptation Inhibition of 2-oxoglutarate dependent oxygenases Redox regulation of mitochondrial function Abnormal sympathoadrenal development and systemic hypotension in PHD3-/- mice The role of PHD2 mutations in the pathogenesis of erythrocytosis.Bacteria, yeast, worms, and flies: exploiting simple model organisms to investigate human mitochondrial diseases No evidence for the role of somatic mutations and promoter hypermethylation of FH gene in the tumorigenesis of nonsyndromic uterine leiomyomas.Metabolic changes and inflammation in cultured astrocytes from the 5xFAD mouse model of Alzheimer's disease: Alleviation by pantethine.Succinate is an inflammatory signal that induces IL-1β through HIF-1α.Intracellular succinylation of 8-chloroadenosine and its effect on fumarate levels.Hypoxia and aerobic metabolism adaptations of human endothelial cells.Metabolic regulation of stem cell function.Altered dynamics of intestinal cell maturation in Apc1638N/+ mice.The oncometabolite fumarate promotes pseudohypoxia through noncanonical activation of NF-κB signaling D-beta-hydroxybutyrate extends lifespan in C. elegans.Metabolic control of renin secretion Reporter ligand NMR screening method for 2-oxoglutarate oxygenase inhibitors.Immunosuppressive activity enhances central carbon metabolism and bioenergetics in myeloid-derived suppressor cells in vitro models.Transplantation of prokaryotic two-component signaling pathways into mammalian cells.2-Oxoglutarate-dependent dioxygenases are sensors of energy metabolism, oxygen availability, and iron homeostasis: potential role in the regulation of aging process.Deregulation of E2-EPF ubiquitin carrier protein in papillary renal cell carcinoma.The proto-oncometabolite fumarate binds glutathione to amplify ROS-dependent signaling.Cardiac anaplerosis in health and disease: food for thought.Proline oxidase functions as a mitochondrial tumor suppressor in human cancers.Prolyl hydroxylation- and glycosylation-dependent functions of Skp1 in O2-regulated development of Dictyostelium Fumaric acid esters stimulate astrocytic VEGF expression through HIF-1α and Nrf2.

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P2860

Inhibition of hypoxia-inducible factor (HIF) hydroxylases by citric acid cycle intermediates: possible links between cell metabolism and stabilization of HIF.

http://www.wikidata.org/entity/Q34001546

description

2006 nî lūn-bûn

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2006 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2006 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2006年の論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年论文

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name

Inhibition of hypoxia-inducibl ...... lism and stabilization of HIF.

@ast

Inhibition of hypoxia-inducibl ...... lism and stabilization of HIF.

@en

Inhibition of hypoxia-inducible factor

@nl

type

label

Inhibition of hypoxia-inducibl ...... lism and stabilization of HIF.

@ast

Inhibition of hypoxia-inducibl ...... lism and stabilization of HIF.

@en

Inhibition of hypoxia-inducible factor

@nl

prefLabel

Inhibition of hypoxia-inducibl ...... lism and stabilization of HIF.

@ast

Inhibition of hypoxia-inducibl ...... lism and stabilization of HIF.

@en

Inhibition of hypoxia-inducible factor

@nl

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P1433

Journal of Biological Chemistry

P1476

Inhibition of hypoxia-inducibl ...... lism and stabilization of HIF.

@en

P2093

Anne M Remes

http://www.w3.org/2001/XMLSchema#string

Ilmo E Hassinen

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Johanna Myllyharju

http://www.w3.org/2001/XMLSchema#string

Kari I Kivirikko

http://www.w3.org/2001/XMLSchema#string

Maija Hirsilä

http://www.w3.org/2001/XMLSchema#string

Peppi Koivunen

http://www.w3.org/2001/XMLSchema#string

P2860

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

A conserved family of prolyl-4-hydroxylases that modify HIF

FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor

Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor.

HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation

HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia

Targeting HIF-1 for cancer therapy

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

Characterization of the human prolyl 4-hydroxylase tetramer and its multifunctional protein disulfide-isomerase subunit synthesized in a baculovirus expression system.

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4524-4532

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scholarly article

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10.1074/JBC.M610415200

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7

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P478

282

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2006-12-19T00:00:00Z

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17182618

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P921