Destabilization of the A1 domain in von Willebrand factor dissociates the A1A2A3 tri-domain and provokes spontaneous binding to glycoprotein Ibalpha and platelet activation under shear stress
about
Von Willebrand factor-A1 domain binds platelet glycoprotein Ibα in multiple states with distinctive force-dependent dissociation kineticsThe linker between the D3 and A1 domains of vWF suppresses A1-GPIbα catch bonds by site-specific binding to the A1 domain.Platelet adhesion involves a novel interaction between vimentin and von Willebrand factor under high shear stressAn HMM-based algorithm for evaluating rates of receptor-ligand binding kinetics from thermal fluctuation data.A recombinant fragment of von Willebrand factor reduces fibrin-rich microthrombi formation in mice with endotoxemiaInteraction of Shiga toxin with the A-domains and multimers of von Willebrand Factor.Misfolding of vWF to pathologically disordered conformations impacts the severity of von Willebrand diseaseEnhanced Local Disorder in a Clinically Elusive von Willebrand Factor Provokes High-Affinity Platelet Clumping.N-terminal flanking region of A1 domain in von Willebrand factor stabilizes structure of A1A2A3 complex and modulates platelet activation under shear stress.Structural origins of misfolding propensity in the platelet adhesive von Willebrand factor A1 domain.Free hemoglobin increases von Willebrand factor-mediated platelet adhesion in vitro: implications for circulatory devices.Differential surface activation of the A1 domain of von Willebrand factor.Acquired von Willebrand syndrome associated with left ventricular assist device.A mechanism for localized dynamics-driven affinity regulation of the binding of von Willebrand factor to platelet glycoprotein Ibα.The N-terminal flanking region of the A1 domain regulates the force-dependent binding of von Willebrand factor to platelet glycoprotein Ibα.An evaluation tool for FKBP12-dependent and -independent mTOR inhibitors using a combination of FKBP-mTOR fusion protein, DSC and NMR.Flow-induced elongation of von Willebrand factor precedes tension-dependent activation.Quantification of Von Willebrand Factor Cleavage by adamts-13 in Patients Supported by Left Ventricular Assist Devices.The Von Willebrand Factor A1-Collagen III Interaction Is Independent of Conformation and Type 2 Von Willebrand Disease Phenotype.The Chaperonin GroEL: A Versatile Tool for Applied Biotechnology Platforms.The functions of the A1A2A3 domains in von Willebrand factor include multimerin 1 binding.Destabilization of the von Willebrand factor A2 domain under oxidizing conditions investigated by molecular dynamics simulationsvon Willebrand Factor, Free Hemoglobin and Thrombosis in ECMO
P2860
Q27303207-07777BC3-C1EC-4478-8D40-958C899D680FQ30557410-BC314D1A-B60A-4268-97E9-DD61C3F7A3DDQ30577008-CCA6D4D1-E478-478D-B0B0-0C424FCD3006Q30618745-A864B9C6-7EBF-47B1-93D3-F4DD2304D3E3Q30836660-C41CF306-AF4A-4881-8F74-B0C5FBFBABF9Q33410767-8A142B42-736B-4B0E-9EA4-2B0C9FC9CB01Q33417479-E9DC650C-D1B2-4B7D-82B0-951FCF1A07CAQ33442035-EBE5B317-015A-4B91-A114-F776D6C57773Q35922561-FE8CD9E4-4066-4F2D-86BF-A53C35C56C01Q36209889-1A77F5B8-8609-46CE-BE6F-89A738A10833Q36274849-F6EB1EBF-5B61-40CB-B750-8672C41A880BQ36678324-4960E134-7692-4864-95AB-6C656DDEFFEDQ37035825-61DBCB9A-AA4C-47FD-98EA-AB72BD7C7C80Q37168411-FC58424C-F902-44AE-9272-ABFD66E5CC76Q37289199-EC446A17-2466-42D9-9558-0A3301F0586EQ38755521-9BFFE454-9EF5-4722-BFC9-CBAB72DDE07EQ41490553-DC60255D-3D22-4803-A3B1-276033DE78B8Q47953130-023B535A-BDED-4CEE-8A22-A283D88F9CEFQ49971473-366F71E4-5774-4406-A95D-546A96E1F500Q54982349-A012B946-269E-4BD1-BEEF-C2FC103F69FDQ55153557-A9830467-1155-40B7-8739-A39C054849F4Q58734805-27B415B7-5C20-4D47-B469-3718719BD94FQ58769597-B1AA79EB-BCE5-4137-A772-0B54E4D1C091
P2860
Destabilization of the A1 domain in von Willebrand factor dissociates the A1A2A3 tri-domain and provokes spontaneous binding to glycoprotein Ibalpha and platelet activation under shear stress
description
2010 nî lūn-bûn
@nan
2010 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Destabilization of the A1 doma ...... activation under shear stress
@ast
Destabilization of the A1 doma ...... activation under shear stress
@en
Destabilization of the A1 doma ...... activation under shear stress
@nl
type
label
Destabilization of the A1 doma ...... activation under shear stress
@ast
Destabilization of the A1 doma ...... activation under shear stress
@en
Destabilization of the A1 doma ...... activation under shear stress
@nl
prefLabel
Destabilization of the A1 doma ...... activation under shear stress
@ast
Destabilization of the A1 doma ...... activation under shear stress
@en
Destabilization of the A1 doma ...... activation under shear stress
@nl
P2093
P2860
P356
P1476
Destabilization of the A1 doma ...... activation under shear stress
@en
P2093
K Vinod Vijayan
Katie E Sowa
Matthew Auton
Miguel A Cruz
Scott M Smith
P2860
P304
22831-22839
P356
10.1074/JBC.M110.103358
P407
P50
P577
2010-05-24T00:00:00Z