SHIP1 inhibition increases immunoregulatory capacity and triggers apoptosis of hematopoietic cancer cells. - Wikidata - wikimedia - TriplyDB

SHIP1 inhibition increases immunoregulatory capacity and triggers apoptosis of hematopoietic cancer cells.

SHIP1 inhibition increases immunoregulatory capacity and triggers apoptosis of hematopoietic cancer cells.

http://www.wikidata.org/entity/Q34008167

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A small-molecule inhibitor of SHIP1 reverses age- and diet-associated obesity and metabolic syndrome Elevated miR-155 promotes inflammation in cystic fibrosis by driving hyperexpression of interleukin-8 Identification of inhibitors of inositol 5-phosphatases through multiple screening strategies.SHIP1 regulates MSC numbers and their osteolineage commitment by limiting induction of the PI3K/Akt/β-catenin/Id2 axis.Deficiency of lipid phosphatase SHIP enables long-term reconstitution of hematopoietic inductive bone marrow microenvironment.Discovery and development of small molecule SHIP phosphatase modulators.Inositol phospholipid signaling and the biology of natural killer cells.Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia SHIPi Enhances Autologous and Allogeneic Hematolymphoid Stem Cell Transplantation.Therapeutic potential of SH2 domain-containing inositol-5'-phosphatase 1 (SHIP1) and SHIP2 inhibition in cancer TLR signaling that induces weak inflammatory response and SHIP1 enhances osteogenic functions.Hypoxia-induced p53 modulates both apoptosis and radiosensitivity via AKT The phosphoinositide 3-kinase signaling pathway in normal and malignant B cells: activation mechanisms, regulation and impact on cellular functions.Blood miRNomes and transcriptomes reveal novel longevity mechanisms in the long-lived bat, Myotis myotis.Synthesis and initial evaluation of quinoline-based inhibitors of the SH2-containing inositol 5'-phosphatase (SHIP).Characterization of AQX-1125, a small-molecule SHIP1 activator: Part 1. Effects on inflammatory cell activation and chemotaxis in vitro and pharmacokinetic characterization in vivo SWAP70 Organizes the Actin Cytoskeleton and Is Essential for Phagocytosis.Lipid phosphatase SHIP2 functions as oncogene in colorectal cancer by regulating PKB activation.Inhibitor and activator: dual functions for SHIP in immunity and cancer.Inositol 5-phosphatases: insights from the Lowe syndrome protein OCRL.Role of inositol phospholipid signaling in natural killer cell biology.Role of SHIP1 in cancer and mucosal inflammation.Role of inositol poly-phosphatases and their targets in T cell biology.Phosphatidylinositolphosphate phosphatase activities and cancer.FcγRIIB-Independent Mechanisms Controlling Membrane Localization of the Inhibitory Phosphatase SHIP in Human B Cells.SHIP2: Structure, Function and Inhibition.Regulation of immune cell signaling by SHIP1: A phosphatase, scaffold protein, and potential therapeutic target.Lineage extrinsic and intrinsic control of immunoregulatory cell numbers by SHIP.Phosphoinositide phosphatase SHIP-1 regulates apoptosis induced by edelfosine, Fas ligation and DNA damage in mouse lymphoma cells.Human Cytomegalovirus Induces an Atypical Activation of Akt To Stimulate the Survival of Short-Lived Monocytes.Analysis of SHIP1 expression and activity in Crohn's disease patients Impaired T-cell survival promotes mucosal inflammatory disease in SHIP1-deficient mice.SHIP deficiency causes Crohn's disease-like ileitis.Pharmacological targeting of phosphoinositide lipid kinases and phosphatases in the immune system: success, disappointment, and new opportunities.Complement Receptor 3 Has Negative Impact on Tumor Surveillance through Suppression of Natural Killer Cell Function.Timescale Separation of Positive and Negative Signaling Creates History-Dependent Responses to IgE Receptor Stimulation.SHIP negatively regulates type II immune responses in mast cells and macrophages.Two SHIPs passing in the middle of the immune system.Src Homology 2 Domain-Containing Inositol 5'-Phosphatase Ameliorates High Glucose-Induced Extracellular Matrix Deposition via the Phosphatidylinositol 3-Kinase/Protein Kinase B Pathway in Renal Tubular Epithelial Cells.SHIP-1 deficiency in the myeloid compartment is insufficient to induce myeloid expansion or chronic inflammation.

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P2860

SHIP1 inhibition increases immunoregulatory capacity and triggers apoptosis of hematopoietic cancer cells.

http://www.wikidata.org/entity/Q34008167

description

2010 nî lūn-bûn

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2010 թուականի Մարտին հրատարակուած գիտական յօդուած

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2010 թվականի մարտին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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SHIP1 inhibition increases imm ...... of hematopoietic cancer cells.

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SHIP1 inhibition increases imm ...... of hematopoietic cancer cells.

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SHIP1 inhibition increases imm ...... of hematopoietic cancer cells.

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SHIP1 inhibition increases imm ...... of hematopoietic cancer cells.

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SHIP1 inhibition increases imm ...... of hematopoietic cancer cells.

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SHIP1 inhibition increases imm ...... of hematopoietic cancer cells.

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SHIP1 inhibition increases imm ...... of hematopoietic cancer cells.

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SHIP1 inhibition increases imm ...... of hematopoietic cancer cells.

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SHIP1 inhibition increases imm ...... of hematopoietic cancer cells.

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Journal of Immunology

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SHIP1 inhibition increases imm ...... of hematopoietic cancer cells

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Gwenny M Fuhler

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Kim H T Paraiso

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Mi-Young Park

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Michelle J Smith

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Robert Brooks

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Robert W Engelman

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Sonia Iyer

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P2860

Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate

SHIP-deficient mice are severely osteoporotic due to increased numbers of hyper-resorptive osteoclasts

Targeted disruption of SHIP leads to hemopoietic perturbations, lung pathology, and a shortened life span

PI3K pathway alterations in cancer: variations on a theme

Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells

Thrombopoietic growth factors and cytokines.

SH2-inositol phosphatase 1 negatively influences early megakaryocyte progenitors

Intracellular delivery of phosphoinositides and inositol phosphates using polyamine carriers

Optimising management of neutropenia and anaemia in cancer chemotherapy-advances in cytokine therapy.

Differential regulation of B cell development, activation, and death by the src homology 2 domain-containing 5' inositol phosphatase (SHIP)

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3582-3589

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10.4049/JIMMUNOL.0902844

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7

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184

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William G. Kerr

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41722089

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20200281

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4123216

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