Differential regulation of B cell development, activation, and death by the src homology 2 domain-containing 5' inositol phosphatase (SHIP)
about
Subcellular localization of Grb2 by the adaptor protein Dok-3 restricts the intensity of Ca2+ signaling in B cellsInhibition of the Jun N-terminal protein kinase pathway by SHIP-1, a lipid phosphatase that interacts with the adaptor molecule Dok-3Vav3 modulates B cell receptor responses by regulating phosphoinositide 3-kinase activationA crucial role for the p110delta subunit of phosphatidylinositol 3-kinase in B cell development and activationRedirection of B cell responsiveness by transforming growth factor beta receptorB-cell receptor signalling and its crosstalk with other pathways in normal and malignant cellsTwo distinct tyrosine-based motifs enable the inhibitory receptor FcgammaRIIB to cooperatively recruit the inositol phosphatases SHIP1/2 and the adapters Grb2/Grap.Fc gamma RIIB1/SHIP-mediated inhibitory signaling in B cells involves lipid rafts.Regulation of the Src homology 2 domain-containing inositol 5'-phosphatase (SHIP1) by the cyclic AMP-dependent protein kinaseSHIP-1 increases early oxidative burst and regulates phagosome maturation in macrophages.Vav activation and function as a rac guanine nucleotide exchange factor in macrophage colony-stimulating factor-induced macrophage chemotaxis.SHIP1 inhibition increases immunoregulatory capacity and triggers apoptosis of hematopoietic cancer cells.Coordinate suppression of B cell lymphoma by PTEN and SHIP phosphatases.Regulation of hematopoietic cell function by inhibitory immunoglobulin G receptors and their inositol lipid phosphatase effectors.Regulation of cell polarity during eukaryotic chemotaxis: the chemotactic compass.PI3Ks in lymphocyte signaling and developmentT cell-specific deletion of the inositol phosphatase SHIP reveals its role in regulating Th1/Th2 and cytotoxic responses.The phosphoinositide 3-kinase signaling pathway in normal and malignant B cells: activation mechanisms, regulation and impact on cellular functions.Cbl-b negatively regulates B cell antigen receptor signaling in mature B cells through ubiquitination of the tyrosine kinase Syk.Phospholipids: "greasing the wheels" of humoral immunityp110δ PI3 kinase pathway: emerging roles in cancer.Ca(2+) signaling in antigen receptor-activated B lymphocytes.Role of phosphoinositide 3-kinase signaling in autoimmunity.Phosphatase regulation of immunoreceptor signaling in T cells, B cells and mast cells.The inhibitory potential of Fc receptor homolog 4 on memory B cells.SHIP is required for a functional hematopoietic stem cell niche.SHIP limits immunoregulatory capacity in the T-cell compartment.Prolactin levels correlate with abnormal B cell maturation in MRL and MRL/lpr mouse models of systemic lupus erythematosus-like diseaseAberrant antibody affinity selection in SHIP-deficient B cells.Inhibitor and activator: dual functions for SHIP in immunity and cancer.Role of inositol poly-phosphatases and their targets in T cell biology.Signaling mechanisms regulating B-lymphocyte activation and tolerance.The Dok-3/Grb2 adaptor module promotes inducible association of the lipid phosphatase SHIP with the BCR in a coreceptor-independent manner.FcγRIIB-Independent Mechanisms Controlling Membrane Localization of the Inhibitory Phosphatase SHIP in Human B Cells.Regulation of immune cell signaling by SHIP1: A phosphatase, scaffold protein, and potential therapeutic target.A critical role for FcgammaRIIB in up-regulation of Fas ligand induced by a microbial polysaccharide.Concerted action of Helios and Ikaros controls the expression of the inositol 5-phosphatase SHIP.Vav and Rac activation in B cell antigen receptor endocytosis involves Vav recruitment to the adapter protein LAB.B cell antigen receptor endocytosis and antigen presentation to T cells require Vav and dynamin.Role of SHIP1 in Invariant NKT Cell Development and Functions.
P2860
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P2860
Differential regulation of B cell development, activation, and death by the src homology 2 domain-containing 5' inositol phosphatase (SHIP)
description
2000 nî lūn-bûn
@nan
2000年の論文
@ja
2000年学术文章
@wuu
2000年学术文章
@zh-cn
2000年学术文章
@zh-hans
2000年学术文章
@zh-my
2000年学术文章
@zh-sg
2000年學術文章
@yue
2000年學術文章
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2000年學術文章
@zh-hant
name
Differential regulation of B c ...... 5' inositol phosphatase (SHIP)
@ast
Differential regulation of B c ...... 5' inositol phosphatase (SHIP)
@en
type
label
Differential regulation of B c ...... 5' inositol phosphatase (SHIP)
@ast
Differential regulation of B c ...... 5' inositol phosphatase (SHIP)
@en
prefLabel
Differential regulation of B c ...... 5' inositol phosphatase (SHIP)
@ast
Differential regulation of B c ...... 5' inositol phosphatase (SHIP)
@en
P2093
P2860
P356
P1476
Differential regulation of B c ...... 5' inositol phosphatase (SHIP)
@en
P2093
A Brauweiler
C D Helgason
J C Cambier
J Dal Porto
R J Benschop
R K Humphries
P2860
P304
P356
10.1084/JEM.191.9.1545
P407
P577
2000-05-01T00:00:00Z