C2A activates a cryptic Ca(2+)-triggered membrane penetration activity within the C2B domain of synaptotagmin I. - Wikidata - wikimedia - TriplyDB

C2A activates a cryptic Ca(2+)-triggered membrane penetration activity within the C2B domain of synaptotagmin I.

C2A activates a cryptic Ca(2+)-triggered membrane penetration activity within the C2B domain of synaptotagmin I.

http://www.wikidata.org/entity/Q34010567

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Augmenting neurotransmitter release by enhancing the apparent Ca2+ affinity of synaptotagmin 1 The iTRAPs: Guardians of Synaptic Vesicle Cargo Retrieval During Endocytosis Lateral diffusion of proteins on supported lipid bilayers: additive friction of synaptotagmin 7 C2A-C2B tandem domains.Identification of synaptotagmin effectors via acute inhibition of secretion from cracked PC12 cells Rat and Drosophila synaptotagmin 4 have opposite effects during SNARE-catalyzed membrane fusion Synaptotagmin-mediated bending of the target membrane is a critical step in Ca(2+)-regulated fusion Endocytic recycling proteins EHD1 and EHD2 interact with fer-1-like-5 (Fer1L5) and mediate myoblast fusion PtdInsP2 and PtdSer cooperate to trap synaptotagmin-1 to the plasma membrane in the presence of calcium.Fluorescence applications in molecular neurobiology Partitioning of synaptotagmin I C2 domains between liquid-ordered and liquid-disordered inner leaflet lipid phases Detection of highly curved membrane surfaces using a cyclic peptide derived from synaptotagmin-I.Vesicular reuptake inhibition by a synaptotagmin I C2B domain antibody at the squid giant synapse.Puzzling Out Synaptic Vesicle 2 Family Members Functions.Three distinct kinetic groupings of the synaptotagmin family: candidate sensors for rapid and delayed exocytosis.Synaptotagmin isoforms couple distinct ranges of Ca2+, Ba2+, and Sr2+ concentration to SNARE-mediated membrane fusion Linker mutations reveal the complexity of synaptotagmin 1 action during synaptic transmission.Characterization of the lipid binding properties of Otoferlin reveals specific interactions between PI(4,5)P2 and the C2C and C2F domains.Synaptotagmin VII is targeted to secretory organelles in PC12 cells, where it functions as a high-affinity calcium sensor.Ca2+-dependent, phospholipid-binding residues of synaptotagmin are critical for excitation-secretion coupling in vivo Meeting of the minds: metalloneurochemistry Role of synaptotagmin in Ca2+-triggered exocytosis.Visualization of synaptotagmin I oligomers assembled onto lipid monolayers.New insights into short-term synaptic facilitation at the frog neuromuscular junction.Membrane penetration by synaptotagmin is required for coupling calcium binding to vesicle fusion in vivo.Ca2+-triggered simultaneous membrane penetration of the tandem C2-domains of synaptotagmin I Mechanism and function of synaptotagmin-mediated membrane apposition.C2B polylysine motif of synaptotagmin facilitates a Ca2+-independent stage of synaptic vesicle priming in vivo.Synaptotagmin function illuminated.Identification of a human synaptotagmin-1 mutation that perturbs synaptic vesicle cycling.Calcium binding promotes conformational flexibility of the neuronal Ca(2+) sensor synaptotagmin.The synaptotagmins: calcium sensors for vesicular trafficking.Structural elements that underlie Doc2β function during asynchronous synaptic transmission.An Engineered Metal Sensor Tunes the Kinetics of Synaptic Transmission.Synaptotagmin C2A loop 2 mediates Ca2+-dependent SNARE interactions essential for Ca2+-triggered vesicle exocytosis Calcium binding by synaptotagmin's C2A domain is an essential element of the electrostatic switch that triggers synchronous synaptic transmission.Functional analysis of the interface between the tandem C2 domains of synaptotagmin-1.Genetic analysis of synaptotagmin C2 domain specificity in regulating spontaneous and evoked neurotransmitter release.Phosphatidylserine regulation of Ca2+-triggered exocytosis and fusion pores in PC12 cells.Mutations that disrupt Ca²⁺-binding activity endow Doc2β with novel functional properties during synaptic transmission.Ferlin proteins in myoblast fusion and muscle growth.

P2860

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P2860

C2A activates a cryptic Ca(2+)-triggered membrane penetration activity within the C2B domain of synaptotagmin I.

http://www.wikidata.org/entity/Q34010567

description

2002 nî lūn-bûn

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2002 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2002 թվականի հունվարին հրատարակված գիտական հոդված

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2002年の論文

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2002年論文

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name

C2A activates a cryptic Ca

@nl

C2A activates a cryptic Ca(2+) ...... C2B domain of synaptotagmin I.

@ast

C2A activates a cryptic Ca(2+) ...... C2B domain of synaptotagmin I.

@en

type

label

C2A activates a cryptic Ca

@nl

C2A activates a cryptic Ca(2+) ...... C2B domain of synaptotagmin I.

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C2A activates a cryptic Ca(2+) ...... C2B domain of synaptotagmin I.

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prefLabel

C2A activates a cryptic Ca

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C2A activates a cryptic Ca(2+) ...... C2B domain of synaptotagmin I.

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C2A activates a cryptic Ca(2+) ...... C2B domain of synaptotagmin I.

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Proceedings of the National Academy of Sciences of the United States of America

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C2A activates a cryptic Ca(2+) ...... C2B domain of synaptotagmin I

@en

P2093

Jihong Bai

http://www.w3.org/2001/XMLSchema#string

Ping Wang

http://www.w3.org/2001/XMLSchema#string

P2860

Initial sequencing and analysis of the human genome

Relationship between presynaptic calcium current and postsynaptic potential in squid giant synapse.

The C2 domain calcium-binding motif: structural and functional diversity

Crystal structure of the cytosolic C2A-C2B domains of synaptotagmin III. Implications for Ca(+2)-independent snare complex interaction

Structure of the first C2 domain of synaptotagmin I: a novel Ca2+/phospholipid-binding fold

C2 domain conformational changes in phospholipase C-delta 1

Synaptotagmin I functions as a calcium regulator of release probability

A single C2 domain from synaptotagmin I is sufficient for high affinity Ca2+/phospholipid binding

Synaptotagmin IV is an immediate early gene induced by depolarization in PC12 cells and in brain

The evolutionary pressure to inactivate. A subclass of synaptotagmins with an amino acid substitution that abolishes Ca2+ binding

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1665-1670

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scholarly article

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10.1073/PNAS.032541099

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3

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99

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Edwin R Chapman

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2002-01-22T00:00:00Z

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11554420

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11805296

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122248

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