Synaptotagmin C2A loop 2 mediates Ca2+-dependent SNARE interactions essential for Ca2+-triggered vesicle exocytosis
about
Dynamic binding mode of a Synaptotagmin-1-SNARE complex in solutionSynaptotagmin-1 binds to PIP(2)-containing membrane but not to SNAREs at physiological ionic strengthSynaptotagmin 1 and SNAREs form a complex that is structurally heterogeneous.Conformation and membrane position of the region linking the two C2 domains in synaptotagmin 1 by site-directed spin labeling.Accessory proteins stabilize the acceptor complex for synaptobrevin, the 1:1 syntaxin/SNAP-25 complexSynaptotagmin interaction with SNAP-25 governs vesicle docking, priming, and fusion triggering.Identification of Differentially Expressed Gene after Femoral Fracture via Microarray ProfilingDifferential regulation of synchronous versus asynchronous neurotransmitter release by the C2 domains of synaptotagmin 1.Solution single-vesicle assay reveals PIP2-mediated sequential actions of synaptotagmin-1 on SNAREs.New insights into short-term synaptic facilitation at the frog neuromuscular junction.Membrane penetration by synaptotagmin is required for coupling calcium binding to vesicle fusion in vivo.Synaptotagmin-1 may be a distance regulator acting upstream of SNARE nucleation.Mechanism and function of synaptotagmin-mediated membrane apposition.Expression, localization, and functional role for synaptotagmins in pancreatic acinar cells.Copper binding affinity of the C2B domain of synaptotagmin-1 and its potential role in the nonclassical secretion of acidic fibroblast growth factor.GPCR mediated regulation of synaptic transmission.Munc13-4 reconstitutes calcium-dependent SNARE-mediated membrane fusion.A role for soluble N-ethylmaleimide-sensitive factor attachment protein receptor complex dimerization during neurosecretion.Synaptic vesicle fusion.The SNAP-25 linker as an adaptation toward fast exocytosis.Synaptotagmins bind calcium to release insulin.Analysis of SNARE complex/synaptotagmin-1 interactions by one-dimensional NMR spectroscopy.The c2 domains of human synaptotagmin 1 have distinct mechanical propertiesThe pre-synaptic vesicle protein synaptotagmin is a novel biomarker for Alzheimer's disease.PI(4,5)P₂-binding effector proteins for vesicle exocytosis.Synaptotagmin-1 utilizes membrane bending and SNARE binding to drive fusion pore expansion.Synaptotagmin C2B domain regulates Ca2+-triggered fusion in vitro: critical residues revealed by scanning alanine mutagenesis.Cyclic AMP-mediated endocytosis of intestinal epithelial NHE3 requires binding to synaptotagmin 1.Direct interaction of otoferlin with syntaxin 1A, SNAP-25, and the L-type voltage-gated calcium channel Cav1.3.Calcium-dependent freezing tolerance in Arabidopsis involves membrane resealing via synaptotagmin SYT1.Small molecules that inhibit the late stage of Munc13-4-dependent secretory granule exocytosis in mast cells.
P2860
Q26269828-4907FE48-2F8C-4944-981B-8C106EC32E3BQ30278658-24BF6727-4472-4D25-AD92-D6A9725B93F0Q30428681-83105364-23EF-436F-A306-D9A0FD5619C2Q30437821-67BE2B64-DB51-4C62-BE0D-8528D2740D7FQ33797927-8374AAB9-4091-4AA4-B891-08F02FEA7800Q33923426-D2E319B7-C310-456E-BA95-F0720DB5B2B5Q33992777-F773E8C7-6123-4831-9D86-96AF888897FBQ34093007-E4DA92FB-23E3-428B-8A4F-B3B27CC0CDE0Q34190825-8E3588F7-01E6-4EEA-9546-FA5C20372698Q34959611-84F89C2B-BDB4-45DF-BF20-AAB3BBE7A928Q34974283-6EA14BFF-BF29-475E-AA3C-563723CAE4A2Q35089488-7A5C4633-7ECD-463E-AA3F-7C78AA125E62Q35089614-EC1E4D97-3D98-498C-9EE7-877B74F9B112Q35159649-F3A57693-E888-4EA1-BE22-3911B56A322DQ35185846-F567FDF6-024C-4F98-B82B-496030940F34Q35870239-B7FF5513-0DF3-441C-BC7D-3072C8D7F7B2Q35894259-A53EB3D7-8757-4D42-8BA0-E6679AC5804DQ36796896-D1D94FDF-B1DA-4D59-9DD1-1A081B610D2DQ36844178-6DD27619-648B-49C0-B053-11421F8BC581Q36854892-F5D38AAB-30CB-43BC-9C5E-A41F178BF81DQ37247487-3548D2B8-4129-4B73-A3CF-F08F38B0E3EBQ37265752-CB879D0E-7DEC-49A9-8E96-37362809BCFBQ37277575-B5C81BA3-F917-4F8E-9C57-9911083E4855Q37307728-D7B53B4C-4ADE-491E-912E-974FEFCA569EQ38256514-63345C20-AB19-44D1-8A92-1102CAA90FFEQ41413294-556FAF2D-84A8-4FE3-8F98-ED3D0A8863C3Q41894155-FD1175C6-BBDA-4FB0-A0FC-BB8AEB81EC23Q42053980-50515D8B-AA73-4856-A42E-9D7B27327BCAQ42138536-78061B51-103F-428F-B6DA-7489586A2E32Q48071856-FA6750D4-4A52-4236-8204-2795D717105AQ55119972-9BF39B5B-C82E-4336-8F81-D423E74BB861
P2860
Synaptotagmin C2A loop 2 mediates Ca2+-dependent SNARE interactions essential for Ca2+-triggered vesicle exocytosis
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Synaptotagmin C2A loop 2 media ...... +-triggered vesicle exocytosis
@ast
Synaptotagmin C2A loop 2 media ...... +-triggered vesicle exocytosis
@en
type
label
Synaptotagmin C2A loop 2 media ...... +-triggered vesicle exocytosis
@ast
Synaptotagmin C2A loop 2 media ...... +-triggered vesicle exocytosis
@en
prefLabel
Synaptotagmin C2A loop 2 media ...... +-triggered vesicle exocytosis
@ast
Synaptotagmin C2A loop 2 media ...... +-triggered vesicle exocytosis
@en
P2093
P2860
P356
P1476
Synaptotagmin C2A loop 2 media ...... +-triggered vesicle exocytosis
@en
P2093
E C Larsen
J C Mitchell
R F Marcia
R R L Gerona
T F J Martin
P2860
P304
P356
10.1091/MBC.E07-04-0368
P577
2007-10-03T00:00:00Z