about
MafA is a glucose-regulated and pancreatic beta-cell-specific transcriptional activator for the insulin geneIdentification of an INSM1-binding site in the insulin promoter: negative regulation of the insulin gene transcriptionThe MafA transcription factor appears to be responsible for tissue-specific expression of insulinGli-similar (Glis) Krüppel-like zinc finger proteins: insights into their physiological functions and critical roles in neonatal diabetes and cystic renal diseaseFoxA2, Nkx2.2, and PDX-1 regulate islet beta-cell-specific mafA expression through conserved sequences located between base pairs -8118 and -7750 upstream from the transcription start siteHES6 reverses nuclear reprogramming of insulin-producing cells following cell fusionTranscription factor regulation of pancreatic organogenesis, differentiation and maturationGlucose induced MAPK signalling influences NeuroD1-mediated activation and nuclear localizationRole of the mitogen-activated protein kinases in cytokine-mediated inhibition of insulin gene expressionRole of intrinsic DNA binding specificity in defining target genes of the mammalian transcription factor PDX1An siRNA screen in pancreatic beta cells reveals a role for Gpr27 in insulin productionRole of chromatin accessibility in the occupancy and transcription of the insulin gene by the pancreatic and duodenal homeobox factor 1.Mechanism of insulin gene regulation by the pancreatic transcription factor Pdx-1: application of pre-mRNA analysis and chromatin immunoprecipitation to assess formation of functional transcriptional complexes.Pdx-1 links histone H3-Lys-4 methylation to RNA polymerase II elongation during activation of insulin transcriptionPdx1 and BETA2/NeuroD1 participate in a transcriptional complex that mediates short-range DNA looping at the insulin gene.In vivo detection of extrapancreatic insulin gene expression in diabetic mice by bioluminescence imagingMultiple chromatin-bound protein kinases assemble factors that regulate insulin gene transcription.Profound defects in pancreatic beta-cell function in mice with combined heterozygous mutations in Pdx-1, Hnf-1alpha, and Hnf-3betaPalmitate inhibits insulin gene expression by altering PDX-1 nuclear localization and reducing MafA expression in isolated rat islets of Langerhans.Global epigenomic analysis of primary human pancreatic islets provides insights into type 2 diabetes susceptibility loci.The insulin gene in diabetes.Development and diseases of the pancreas.Identification of glucose-regulated miRNAs from pancreatic {beta} cells reveals a role for miR-30d in insulin transcriptionWidespread dysregulation of peptide hormone release in mice lacking adaptor protein AP-3.Heterogeneity in predisposition of hepatic cells to be induced into pancreatic endocrine cells by PDX-1.Modulation of the transactivation function and stability of Krüppel-like zinc finger protein Gli-similar 3 (Glis3) by Suppressor of Fused.Pancreatic islet cell therapy for type I diabetes: understanding the effects of glucose stimulation on islets in order to produce better islets for transplantation.A small molecule differentiation inducer increases insulin production by pancreatic β cellsConserved role for the Dachshund protein with Drosophila Pax6 homolog Eyeless in insulin expressionPlasticity of the beta cell insulin secretory competence: preparing the pancreatic beta cell for the next meal.Glucose induces MafA expression in pancreatic beta cell lines via the hexosamine biosynthetic pathway.Differential regulation of CHOP-10/GADD153 gene expression by MAPK signaling in pancreatic beta-cells.GPR41 gene expression is mediated by internal ribosome entry site (IRES)-dependent translation of bicistronic mRNA encoding GPR40 and GPR41 proteins.Islet autoantigens: structure, function, localization, and regulation.MicroRNA-30d induces insulin transcription factor MafA and insulin production by targeting mitogen-activated protein 4 kinase 4 (MAP4K4) in pancreatic β-cells.Extrapancreatic insulin-producing cells in multiple organs in diabetesAntidiabetic effect and mode of action of cytopiloyneUpdate on the protective molecular pathways improving pancreatic beta-cell dysfunctionChromatin-bound mitogen-activated protein kinases transmit dynamic signals in transcription complexes in beta-cells.Multiple kinases regulate mafA expression in the pancreatic beta cell line MIN6.
P2860
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P2860
description
2000 nî lūn-bûn
@nan
2000 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Regulation of insulin gene transcription.
@ast
Regulation of insulin gene transcription.
@en
Regulation of insulin gene transcription.
@nl
type
label
Regulation of insulin gene transcription.
@ast
Regulation of insulin gene transcription.
@en
Regulation of insulin gene transcription.
@nl
prefLabel
Regulation of insulin gene transcription.
@ast
Regulation of insulin gene transcription.
@en
Regulation of insulin gene transcription.
@nl
P2093
P356
P1476
Regulation of insulin gene transcription.
@en
P2093
P304
P356
10.1006/SCDB.2000.0171
P577
2000-08-01T00:00:00Z