Profound defects in pancreatic beta-cell function in mice with combined heterozygous mutations in Pdx-1, Hnf-1alpha, and Hnf-3beta - Wikidata - wikimedia - TriplyDB

Profound defects in pancreatic beta-cell function in mice with combined heterozygous mutations in Pdx-1, Hnf-1alpha, and Hnf-3beta

Profound defects in pancreatic beta-cell function in mice with combined heterozygous mutations in Pdx-1, Hnf-1alpha, and Hnf-3beta

http://www.wikidata.org/entity/Q34020577

about

miR-375 maintains normal pancreatic alpha- and beta-cell mass Pancreatic-duodenal homeobox 1 regulates expression of liver receptor homolog 1 during pancreas development Increased islet apoptosis in Pdx1+/- mice Maintenance of β-cell maturity and plasticity in the adult pancreas: developmental biology concepts in adult physiology Epistasis of transcriptomes reveals synergism between transcriptional activators Hnf1alpha and Hnf4alpha Chronic alcohol consumption potentiates the development of diabetes through pancreatic β-cell dysfunction Nkx2.2 regulates beta-cell function in the mature islet Targeted deletion of a cis-regulatory region reveals differential gene dosage requirements for Pdx1 in foregut organ differentiation and pancreas formation.MicroRNAs in adipogenesis and as therapeutic targets for obesity.Assessing tumor progression factors by somatic gene transfer into a mouse model: Bcl-xL promotes islet tumor cell invasion.Activation of PyMT in beta cells induces irreversible hyperplasia, but oncogene-dependent acinar cell carcinomas when activated in pancreatic progenitors.Diabetes and pancreatic cancer.Role of Foxa-2 in adipocyte metabolism and differentiation Glucokinase and IRS-2 are required for compensatory beta cell hyperplasia in response to high-fat diet-induced insulin resistance.Pancreas-specific deletion of mouse Gata4 and Gata6 causes pancreatic agenesis Protein-mediated interactions of pancreatic islet cells The Fox genes in the liver: from organogenesis to functional integration.Role of heme oxygenase in inflammation, insulin-signalling, diabetes and obesity.Impact of islet architecture on β-cell heterogeneity, plasticity and function.Development of novel cell lines of diabetic dysfunction model fit for cell-based screening tests of medicinal materials.Nucleo-cytosolic shuttling of FoxO1 directly regulates mouse Ins2 but not Ins1 gene expression in pancreatic beta cells (MIN6).The involvement of epigenetic silencing of Foxa2 in cellular replicative and premature senescence induced by hydrogen peroxide.PDX-1 haploinsufficiency limits the compensatory islet hyperplasia that occurs in response to insulin resistance.The G115S mutation associated with maturity-onset diabetes of the young impairs hepatocyte nuclear factor 4alpha activities and introduces a PKA phosphorylation site in its DNA-binding domain.Distinct roles for insulin and insulin-like growth factor-1 receptors in pancreatic beta-cell glucose sensing revealed by RNA silencing Functional, persistent, and extended liver to pancreas transdifferentiation.Glucose regulates insulin gene transcription by hyperacetylation of histone h4.The identification of potential factors associated with the development of type 2 diabetes: a quantitative proteomics approach Aldehyde dehydrogenase activity is necessary for beta cell development and functionality in mice.Pleiotropic Roles of PDX-1 in the Pancreas Vascular endothelial growth factor-mediated islet hypervascularization and inflammation contribute to progressive reduction of β-cell mass.Cell-to-cell contact dependence and junctional protein content are correlated with in vivo maturation of pancreatic beta cells.Pdx1 expression in Irs2-deficient mouse beta-cells is regulated in a strain-dependent manner.Reduced PDX-1 expression impairs islet response to insulin resistance and worsens glucose homeostasis.Alx3-deficient mice exhibit decreased insulin in beta cells, altered glucose homeostasis and increased apoptosis in pancreatic islets.Control of beta cell function and proliferation in mice stimulated by small-molecule glucokinase activator under various conditions.

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P2860

Profound defects in pancreatic beta-cell function in mice with combined heterozygous mutations in Pdx-1, Hnf-1alpha, and Hnf-3beta

http://www.wikidata.org/entity/Q34020577

description

2002 nî lūn-bûn

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2002 թուականի Մարտին հրատարակուած գիտական յօդուած

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2002 թվականի մարտին հրատարակված գիտական հոդված

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Profound defects in pancreatic ...... x-1, Hnf-1alpha, and Hnf-3beta

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Profound defects in pancreatic ...... x-1, Hnf-1alpha, and Hnf-3beta

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Profound defects in pancreatic ...... x-1, Hnf-1alpha, and Hnf-3beta

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Profound defects in pancreatic ...... x-1, Hnf-1alpha, and Hnf-3beta

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Profound defects in pancreatic ...... x-1, Hnf-1alpha, and Hnf-3beta

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Profound defects in pancreatic ...... x-1, Hnf-1alpha, and Hnf-3beta

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Profound defects in pancreatic ...... x-1, Hnf-1alpha, and Hnf-3beta

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P1433

Proceedings of the National Academy of Sciences of the United States of America

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Profound defects in pancreatic ...... x-1, Hnf-1alpha, and Hnf-3beta

@en

P2093

Christopher V E Wright

http://www.w3.org/2001/XMLSchema#string

David Q Shih

http://www.w3.org/2001/XMLSchema#string

Markus Heimesaat

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Markus Stoffel

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Roland Stein

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Satoru Kuwajima

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P2860

Tissue-specific deletion of Foxa2 in pancreatic beta cells results in hyperinsulinemic hypoglycemia

Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic beta cells

Essential role for the homeoprotein vHNF1/HNF1beta in visceral endoderm differentiation

Variant hepatocyte nuclear factor 1 is required for visceral endoderm specification

A causal role for E-cadherin in the transition from adenoma to carcinoma

Pancreas development and diabetes.

A transcription factor regulatory circuit in differentiated pancreatic cells.

Regulation of insulin gene transcription.

Developmental biology of the pancreas.

Nucleosome positioning by the winged helix transcription factor HNF3

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10.1073/PNAS.062605899

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6

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99

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2002-03-01T00:00:00Z

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11460474

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11904435

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122607

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