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Identification of the enzymatic mechanism of nitroglycerin bioactivation

Identification of the enzymatic mechanism of nitroglycerin bioactivation

http://www.wikidata.org/entity/Q34032459

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An essential role for mitochondrial aldehyde dehydrogenase in nitroglycerin bioactivation Recent advances in the management of chronic stable angina II. Anti-ischemic therapy, options for refractory angina, risk factor reduction, and revascularization.NO-independent stimulators and activators of soluble guanylate cyclase: discovery and therapeutic potential Nitroxyl (HNO): A Reduced Form of Nitric Oxide with Distinct Chemical, Pharmacological, and Therapeutic Properties Organic Nitrate Therapy, Nitrate Tolerance, and Nitrate-Induced Endothelial Dysfunction: Emphasis on Redox Biology and Oxidative Stress Nitric oxide synthases in heart failure S-nitrosothiols and the S-nitrosoproteome of the cardiovascular system Development of an on-animal separation-based sensor for monitoring drug metabolism in freely roaming sheep Structural and Functional Consequences of Coenzyme Binding to the Inactive Asian Variant of Mitochondrial Aldehyde Dehydrogenase: ROLES OF RESIDUES 475 AND 487 Vascular Bioactivation of Nitroglycerin by Aldehyde Dehydrogenase-2: REACTION INTERMEDIATES REVEALED BY CRYSTALLOGRAPHY AND MASS SPECTROMETRY Aldehyde dehydrogenase inhibitors: a comprehensive review of the pharmacology, mechanism of action, substrate specificity, and clinical application Characterization of the mechanism of cytochrome P450 reductase-cytochrome P450-mediated nitric oxide and nitrosothiol generation from organic nitrates Mitochondrial aldehyde dehydrogenase attenuates hyperoxia-induced cell death through activation of ERK/MAPK and PI3K-Akt pathways in lung epithelial cells Characterization of the molecular mechanisms underlying increased ischemic damage in the aldehyde dehydrogenase 2 genetic polymorphism using a human induced pluripotent stem cell model system.Mitochondrial oxidative stress and nitrate tolerance--comparison of nitroglycerin and pentaerithrityl tetranitrate in Mn-SOD+/- mice.Assessment of endothelial cell function and physiological microcirculatory reserve by video microscopy using a topical acetylcholine and nitroglycerin challenge.Development of selective inhibitors for human aldehyde dehydrogenase 3A1 (ALDH3A1) for the enhancement of cyclophosphamide cytotoxicity.European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS).Synthesis and characterization of a novel organic nitrate NDHP: Role of xanthine oxidoreductase-mediated nitric oxide formation.Mitochondrial aldehyde dehydrogenase-2 deficiency compromises therapeutic effect of ALDH bright cell on peripheral ischemia Aldehyde dehydrogenase 2 in cardiac protection: a new therapeutic target?Discovery of novel regulators of aldehyde dehydrogenase isoenzymes Nitrates and nitrites in the treatment of ischemic cardiac disease Aldehyde dehydrogenases: from eye crystallins to metabolic disease and cancer stem cells After 130 years, the molecular mechanism of action of nitroglycerin is revealed.The nitric oxide pathway and possible therapeutic options in pre-eclampsia Disruption of the coenzyme binding site and dimer interface revealed in the crystal structure of mitochondrial aldehyde dehydrogenase "Asian" variant.Mitochondrial aldehyde dehydrogenase and cardiac diseases.Mitochondrial aldehyde dehydrogenase mediates vasodilator responses of glyceryl trinitrate and sodium nitrite in the pulmonary vascular bed of the rat The Reemergence of Nitrite as a Beneficial Agent in the Treatment of Ischemic Cardiovascular Diseases Mitochondrial aldehyde dehydrogenase-2 (ALDH2) Glu504Lys polymorphism contributes to the variation in efficacy of sublingual nitroglycerin.Daily low-dose folic acid supplementation does not prevent nitroglycerin-induced nitric oxide synthase dysfunction and tolerance: a human in vivo study.Targeting aldehyde dehydrogenase 2: new therapeutic opportunities.Nitrolinoleate, a nitric oxide-derived mediator of cell function: synthesis, characterization, and vasomotor activity.Organic nitrates and nitrate resistance in diabetes: the role of vascular dysfunction and oxidative stress with emphasis on antioxidant properties of pentaerithrityl tetranitrate.The sodium-glucose co-transporter 2 inhibitor empagliflozin improves diabetes-induced vascular dysfunction in the streptozotocin diabetes rat model by interfering with oxidative stress and glucotoxicity Reversal to cisplatin sensitivity in recurrent human ovarian cancer cells by NCX-4016, a nitro derivative of aspirin Mitochondrial aldehyde dehydrogenase prevents ROS-induced vascular contraction in angiotensin-II hypertensive mice.A new class of organic nitrates: investigations on bioactivation, tolerance and cross-tolerance phenomena.Insights into the effect of nitric oxide and its metabolites nitrite and nitrate at inhibiting neointimal hyperplasia.

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P2860

Identification of the enzymatic mechanism of nitroglycerin bioactivation

http://www.wikidata.org/entity/Q34032459

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2002 nî lūn-bûn

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2002 թուականի Յունիսին հրատարակուած գիտական յօդուած

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name

Identification of the enzymatic mechanism of nitroglycerin bioactivation

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Identification of the enzymatic mechanism of nitroglycerin bioactivation

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Identification of the enzymatic mechanism of nitroglycerin bioactivation

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Identification of the enzymatic mechanism of nitroglycerin bioactivation

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Identification of the enzymatic mechanism of nitroglycerin bioactivation

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Identification of the enzymatic mechanism of nitroglycerin bioactivation

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Identification of the enzymatic mechanism of nitroglycerin bioactivation

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Identification of the enzymatic mechanism of nitroglycerin bioactivation

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Identification of the enzymatic mechanism of nitroglycerin bioactivation

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Proceedings of the National Academy of Sciences of the United States of America

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Identification of the enzymatic mechanism of nitroglycerin bioactivation

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Jian Zhang

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Jonathan S Stamler

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Zhiqiang Chen

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P2860

Inhibition of NADPH-cytochrome P450 reductase and glyceryl trinitrate biotransformation by diphenyleneiodonium sulfate

Isoform-specific biotransformation of glyceryl trinitrate by rat aortic glutathione S-transferases

Nitrate tolerance is specific for nitric acid esters and its recovery requires an intact protein synthesis.

Role of disulfiram in the in vitro inhibition of rat liver mitochondrial aldehyde dehydrogenase.

Role of aldehyde dehydrogenases in endogenous and xenobiotic metabolism.

Evidence for enhanced vascular superoxide anion production in nitrate tolerance. A novel mechanism underlying tolerance and cross-tolerance.

Human aldehyde dehydrogenase: mechanism of inhibition of disulfiram.

Guanylate cyclase: activation by azide, nitro compounds, nitric oxide, and hydroxyl radical and inhibition by hemoglobin and myoglobin.

Biotransformation of glyceryl trinitrate and elevation of cyclic GMP precede glyceryl trinitrate-induced vasodilation.

Biotransformation of glyceryl trinitrate and isosorbide dinitrate in vascular smooth muscle made tolerant to organic nitrates.

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