Rapid directional shift of mitochondrial DNA heteroplasmy in animal tissues by a mitochondrially targeted restriction endonuclease
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Generation of Rho Zero Cells: Visualization and Quantification of the mtDNA Depletion ProcessMitochondrial Function in Allergic Disease.Bioenergetics in human evolution and disease: implications for the origins of biological complexity and the missing genetic variation of common diseases.Establishment of a new method for precisely determining the functions of individual mitochondrial genes, using Dictyostelium cells.Modeling of antigenomic therapy of mitochondrial diseases by mitochondrially addressed RNA targeting a pathogenic point mutation in mitochondrial DNAParkin overexpression selects against a deleterious mtDNA mutation in heteroplasmic cybrid cellsSpecific elimination of mutant mitochondrial genomes in patient-derived cells by mitoTALENs.Leber's Hereditary Optic Neuropathy-Gene Therapy: From Benchtop to Bedside.Cell and animal models of mtDNA biology: progress and prospects.The use of mitochondria-targeted endonucleases to manipulate mtDNAMitochondrial nucleoids maintain genetic autonomy but allow for functional complementation.Efficiency and safety of AAV-mediated gene delivery of the human ND4 complex I subunit in the mouse visual systemUV-laser-based microscopic dissection of tree rings - a novel sampling tool for δ(13) C and δ(18) O studies.Organ-specific shifts in mtDNA heteroplasmy following systemic delivery of a mitochondria-targeted restriction endonuclease.Mitochondrial energetics and therapeutics.Real-Time PCR Quantification of Heteroplasmy in a Mouse Model with Mitochondrial DNA of C57BL/6 and NZB/BINJ StrainsMitochondrial Diseases Part III: Therapeutic interventions in mouse models of OXPHOS deficiencies.Near-complete elimination of mutant mtDNA by iterative or dynamic dose-controlled treatment with mtZFNs.Manipulation of mtDNA heteroplasmy in all striated muscles of newborn mice by AAV9-mediated delivery of a mitochondria-targeted restriction endonuclease.Induction of rapid and highly efficient expression of the human ND4 complex I subunit in the mouse visual system by self-complementary adeno-associated virus.The mitochondrial genome, a growing interest inside an organelle.Modifying the Mitochondrial Genome.Persistent damage induces mitochondrial DNA degradation.Phosphorylated neurofilament heavy chain is a marker of neurodegeneration in Leber hereditary optic neuropathy (LHON)Absence of autophagy results in reactive oxygen species-dependent amplification of RLR signaling.Mouse models of oxidative phosphorylation defects: powerful tools to study the pathobiology of mitochondrial diseases.Intra- and inter-molecular recombination of mitochondrial DNA after in vivo induction of multiple double-strand breaks.A Phenotype-Driven Approach to Generate Mouse Models with Pathogenic mtDNA Mutations Causing Mitochondrial Disease.Modulating mtDNA heteroplasmy by mitochondria-targeted restriction endonucleases in a 'differential multiple cleavage-site' model.Selective removal of deletion-bearing mitochondrial DNA in heteroplasmic Drosophila.Mitochondrial medicine for neurodegenerative diseases.Mitochondrially targeted ZFNs for selective degradation of pathogenic mitochondrial genomes bearing large-scale deletions or point mutations.Altering the balance between healthy and mutated mitochondrial DNA.Neurodevelopmental manifestations of mitochondrial disease.Targeting autophagy and mitophagy for mitochondrial diseases treatment.MitoTALEN: A General Approach to Reduce Mutant mtDNA Loads and Restore Oxidative Phosphorylation Function in Mitochondrial Diseases.Advances in molecular diagnostics for mitochondrial diseases.Development of a single-chain, quasi-dimeric zinc-finger nuclease for the selective degradation of mutated human mitochondrial DNA.Mechanisms of formation and accumulation of mitochondrial DNA deletions in aging neurons.Transient mitochondrial DNA double strand breaks in mice cause accelerated aging phenotypes in a ROS-dependent but p53/p21-independent manner.
P2860
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P2860
Rapid directional shift of mitochondrial DNA heteroplasmy in animal tissues by a mitochondrially targeted restriction endonuclease
description
2005 nî lūn-bûn
@nan
2005 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Rapid directional shift of mit ...... geted restriction endonuclease
@ast
Rapid directional shift of mit ...... geted restriction endonuclease
@en
Rapid directional shift of mit ...... geted restriction endonuclease
@nl
type
label
Rapid directional shift of mit ...... geted restriction endonuclease
@ast
Rapid directional shift of mit ...... geted restriction endonuclease
@en
Rapid directional shift of mit ...... geted restriction endonuclease
@nl
prefLabel
Rapid directional shift of mit ...... geted restriction endonuclease
@ast
Rapid directional shift of mit ...... geted restriction endonuclease
@en
Rapid directional shift of mit ...... geted restriction endonuclease
@nl
P2093
P2860
P356
P1476
Rapid directional shift of mit ...... geted restriction endonuclease
@en
P2093
Brendan J Battersby
Carlos T Moraes
Eric A Shoubridge
Maria Pilar Bayona-Bafaluy
P2860
P304
14392-14397
P356
10.1073/PNAS.0502896102
P407
P577
2005-09-22T00:00:00Z