Rapid directional shift of mitochondrial DNA heteroplasmy in animal tissues by a mitochondrially targeted restriction endonuclease - Wikidata - wikimedia - TriplyDB

Rapid directional shift of mitochondrial DNA heteroplasmy in animal tissues by a mitochondrially targeted restriction endonuclease

Rapid directional shift of mitochondrial DNA heteroplasmy in animal tissues by a mitochondrially targeted restriction endonuclease

http://www.wikidata.org/entity/Q34063452

about

Generation of Rho Zero Cells: Visualization and Quantification of the mtDNA Depletion Process Mitochondrial Function in Allergic Disease.Bioenergetics in human evolution and disease: implications for the origins of biological complexity and the missing genetic variation of common diseases.Establishment of a new method for precisely determining the functions of individual mitochondrial genes, using Dictyostelium cells.Modeling of antigenomic therapy of mitochondrial diseases by mitochondrially addressed RNA targeting a pathogenic point mutation in mitochondrial DNA Parkin overexpression selects against a deleterious mtDNA mutation in heteroplasmic cybrid cells Specific elimination of mutant mitochondrial genomes in patient-derived cells by mitoTALENs.Leber's Hereditary Optic Neuropathy-Gene Therapy: From Benchtop to Bedside.Cell and animal models of mtDNA biology: progress and prospects.The use of mitochondria-targeted endonucleases to manipulate mtDNA Mitochondrial nucleoids maintain genetic autonomy but allow for functional complementation.Efficiency and safety of AAV-mediated gene delivery of the human ND4 complex I subunit in the mouse visual system UV-laser-based microscopic dissection of tree rings - a novel sampling tool for δ(13) C and δ(18) O studies.Organ-specific shifts in mtDNA heteroplasmy following systemic delivery of a mitochondria-targeted restriction endonuclease.Mitochondrial energetics and therapeutics.Real-Time PCR Quantification of Heteroplasmy in a Mouse Model with Mitochondrial DNA of C57BL/6 and NZB/BINJ Strains Mitochondrial Diseases Part III: Therapeutic interventions in mouse models of OXPHOS deficiencies.Near-complete elimination of mutant mtDNA by iterative or dynamic dose-controlled treatment with mtZFNs.Manipulation of mtDNA heteroplasmy in all striated muscles of newborn mice by AAV9-mediated delivery of a mitochondria-targeted restriction endonuclease.Induction of rapid and highly efficient expression of the human ND4 complex I subunit in the mouse visual system by self-complementary adeno-associated virus.The mitochondrial genome, a growing interest inside an organelle.Modifying the Mitochondrial Genome.Persistent damage induces mitochondrial DNA degradation.Phosphorylated neurofilament heavy chain is a marker of neurodegeneration in Leber hereditary optic neuropathy (LHON)Absence of autophagy results in reactive oxygen species-dependent amplification of RLR signaling.Mouse models of oxidative phosphorylation defects: powerful tools to study the pathobiology of mitochondrial diseases.Intra- and inter-molecular recombination of mitochondrial DNA after in vivo induction of multiple double-strand breaks.A Phenotype-Driven Approach to Generate Mouse Models with Pathogenic mtDNA Mutations Causing Mitochondrial Disease.Modulating mtDNA heteroplasmy by mitochondria-targeted restriction endonucleases in a 'differential multiple cleavage-site' model.Selective removal of deletion-bearing mitochondrial DNA in heteroplasmic Drosophila.Mitochondrial medicine for neurodegenerative diseases.Mitochondrially targeted ZFNs for selective degradation of pathogenic mitochondrial genomes bearing large-scale deletions or point mutations.Altering the balance between healthy and mutated mitochondrial DNA.Neurodevelopmental manifestations of mitochondrial disease.Targeting autophagy and mitophagy for mitochondrial diseases treatment.MitoTALEN: A General Approach to Reduce Mutant mtDNA Loads and Restore Oxidative Phosphorylation Function in Mitochondrial Diseases.Advances in molecular diagnostics for mitochondrial diseases.Development of a single-chain, quasi-dimeric zinc-finger nuclease for the selective degradation of mutated human mitochondrial DNA.Mechanisms of formation and accumulation of mitochondrial DNA deletions in aging neurons.Transient mitochondrial DNA double strand breaks in mice cause accelerated aging phenotypes in a ROS-dependent but p53/p21-independent manner.

P2860

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P2860

Rapid directional shift of mitochondrial DNA heteroplasmy in animal tissues by a mitochondrially targeted restriction endonuclease

http://www.wikidata.org/entity/Q34063452

description

2005 nî lūn-bûn

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2005 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2005 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2005年の論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年论文

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name

Rapid directional shift of mit ...... geted restriction endonuclease

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Rapid directional shift of mit ...... geted restriction endonuclease

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Rapid directional shift of mit ...... geted restriction endonuclease

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Rapid directional shift of mit ...... geted restriction endonuclease

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Rapid directional shift of mit ...... geted restriction endonuclease

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Rapid directional shift of mit ...... geted restriction endonuclease

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prefLabel

Rapid directional shift of mit ...... geted restriction endonuclease

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Rapid directional shift of mit ...... geted restriction endonuclease

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Rapid directional shift of mit ...... geted restriction endonuclease

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Proceedings of the National Academy of Sciences of the United States of America

P1476

Rapid directional shift of mit ...... geted restriction endonuclease

@en

P2093

Bas Blits

http://www.w3.org/2001/XMLSchema#string

Brendan J Battersby

http://www.w3.org/2001/XMLSchema#string

Carlos T Moraes

http://www.w3.org/2001/XMLSchema#string

Eric A Shoubridge

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Maria Pilar Bayona-Bafaluy

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P2860

Composition and dynamics of human mitochondrial nucleoids

In organello formaldehyde crosslinking of proteins to mtDNA: identification of bifunctional proteins.

Complete restoration of a wild-type mtDNA genotype in regenerating muscle fibres in a patient with a tRNA point mutation and mitochondrial encephalomyopathy

Mitochondrial respiratory-chain diseases

An antiprogestin regulable gene switch for induction of gene expression in vivo.

Double-strand breaks of mouse muscle mtDNA promote large deletions similar to multiple mtDNA deletions in humans.

Adeno-associated virus vectors for gene therapy: more pros than cons?

Inducible expression of a dominant negative DNA polymerase-gamma depletes mitochondrial DNA and produces a rho0 phenotype.

Molecular basis for treatment of mitochondrial myopathies.

Organization and dynamics of human mitochondrial DNA.

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40

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102

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7585415

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16179392

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mitochondrial DNA

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1242285

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