Development of a single-chain, quasi-dimeric zinc-finger nuclease for the selective degradation of mutated human mitochondrial DNA. - Wikidata - wikimedia - TriplyDB

Development of a single-chain, quasi-dimeric zinc-finger nuclease for the selective degradation of mutated human mitochondrial DNA.

Development of a single-chain, quasi-dimeric zinc-finger nuclease for the selective degradation of mutated human mitochondrial DNA.

http://www.wikidata.org/entity/Q39977270

about

Progress and prospects: zinc-finger nucleases as gene therapy agents Genetic manipulation for inherited neurodegenerative diseases: myth or reality?Mitochondrial DNA disease-molecular insights and potential routes to a cure Liver-targeted gene therapy: Approaches and challenges Zinc finger nucleases as tools to understand and treat human diseases.Specific elimination of mutant mitochondrial genomes in patient-derived cells by mitoTALENs.Re-engineering the mitochondrial genomes in mammalian cells Therapeutic prospects for mitochondrial disease.Selective elimination of mitochondrial mutations in the germline by genome editing The use of mitochondria-targeted endonucleases to manipulate mtDNA A single-chain TALEN architecture for genome engineering.The generation of zinc finger proteins by modular assembly.Organ-specific shifts in mtDNA heteroplasmy following systemic delivery of a mitochondria-targeted restriction endonuclease.Mitochondrial disease: clinical aspects, molecular mechanisms, translational science, and clinical frontiers.Near-complete elimination of mutant mtDNA by iterative or dynamic dose-controlled treatment with mtZFNs.Mitochondrial DNA Heteroplasmy Associations With Neurosensory and Mobility Function in Elderly Adults.EENdb: a database and knowledge base of ZFNs and TALENs for endonuclease engineering Mitochondrial targeting of recombinant RNAs modulates the level of a heteroplasmic mutation in human mitochondrial DNA associated with Kearns Sayre Syndrome Modifying the Mitochondrial Genome.Emerging therapies for mitochondrial disorders.Selective removal of deletion-bearing mitochondrial DNA in heteroplasmic Drosophila.Targeted approaches for gene therapy and the emergence of engineered meganucleases.Mitochondrially targeted ZFNs for selective degradation of pathogenic mitochondrial genomes bearing large-scale deletions or point mutations.The approaches for manipulating mitochondrial proteome Towards artificial metallonucleases for gene therapy: recent advances and new perspectives.Genome modifications in plant cells by custom-made restriction enzymes.Transgenic chickens.Nuclease-mediated genome editing: At the front-line of functional genomics technology.Emerging aspects of treatment in mitochondrial disorders.Gene editing technology as an approach to the treatment of liver diseases.Engineering and optimising deaminase fusions for genome editing.MitoTALEN: A General Approach to Reduce Mutant mtDNA Loads and Restore Oxidative Phosphorylation Function in Mitochondrial Diseases.Targeting individual subunits of the FokI restriction endonuclease to specific DNA strands.Assembly and in vitro functional analysis of zinc finger nuclease specific to the 3' untranslated region of chicken ovalbumin gene.Scientific opinion addressing the safety assessment of plants developed using Zinc Finger Nuclease 3 and other Site-Directed Nucleases with similar function Mitochondrial Genome Engineering: The Revolution May Not Be CRISPR-Ized.Applications of Alternative Nucleases in the Age of CRISPR/Cas9.Mitochondrial Haplotype Alters Mammary Cancer Tumorigenicity and Metastasis in an Oncogenic Driver-Dependent Manner.Continuous genetic recording with self-targeting CRISPR-Cas in human cells.Precision genetic modifications: a new era in molecular biology and crop improvement.

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P2860

Development of a single-chain, quasi-dimeric zinc-finger nuclease for the selective degradation of mutated human mitochondrial DNA.

http://www.wikidata.org/entity/Q39977270

description

2008 nî lūn-bûn

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2008年の論文

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2008年学术文章

@wuu

2008年学术文章

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2008年学术文章

@zh-hans

2008年学术文章

@zh-my

2008年学术文章

@zh-sg

2008年學術文章

@yue

2008年學術文章

@zh

2008年學術文章

@zh-hant

name

Development of a single-chain, ...... tated human mitochondrial DNA.

@en

Development of a single-chain, ...... tated human mitochondrial DNA.

@nl

type

label

Development of a single-chain, ...... tated human mitochondrial DNA.

@en

Development of a single-chain, ...... tated human mitochondrial DNA.

@nl

prefLabel

Development of a single-chain, ...... tated human mitochondrial DNA.

@en

Development of a single-chain, ...... tated human mitochondrial DNA.

@nl

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P1433

Nucleic Acids Research

P1476

Development of a single-chain, ...... tated human mitochondrial DNA.

@en

P2093

Aaron Klug

http://www.w3.org/2001/XMLSchema#string

Jeffrey C Miller

http://www.w3.org/2001/XMLSchema#string

Michal Minczuk

http://www.w3.org/2001/XMLSchema#string

Monika A Papworth

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P2860

Localisation of the human hSuv3p helicase in the mitochondrial matrix and its preferential unwinding of dsDNA

The NS2 proteins of parvovirus minute virus of mice are required for efficient nuclear egress of progeny virions in mouse cells.

Hybrid restriction enzymes: zinc finger fusions to Fok I cleavage domain

A rapid, generally applicable method to engineer zinc fingers illustrated by targeting the HIV-1 promoter

Composition and dynamics of human mitochondrial nucleoids

Highly efficient endogenous human gene correction using designed zinc-finger nucleases

Designer zinc-finger proteins and their applications

An improved zinc-finger nuclease architecture for highly specific genome editing

Requirements for double-strand cleavage by chimeric restriction enzymes with zinc finger DNA-recognition domains

Identification of mammalian TOM22 as a subunit of the preprotein translocase of the mitochondrial outer membrane.

P304

3926-3938

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scholarly article

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10.1093/NAR/GKN313

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12

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P478

36

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Michael P. Murphy

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2008-05-29T00:00:00Z

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5340367

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P698

18511461

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P921

mitochondrial DNA

P932

2475635

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