Hydrocarbon double-stapling remedies the proteolytic instability of a lengthy peptide therapeutic - Wikidata - wikimedia - TriplyDB

Hydrocarbon double-stapling remedies the proteolytic instability of a lengthy peptide therapeutic

Hydrocarbon double-stapling remedies the proteolytic instability of a lengthy peptide therapeutic

http://www.wikidata.org/entity/Q34069846

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Targeted disruption of the BCL9/β-catenin complex inhibits oncogenic Wnt signaling Getting in shape: controlling peptide bioactivity and bioavailability using conformational constraints Stapled BH3 peptides against MCL-1: mechanism and design using atomistic simulations Inhibition of oncogenic Wnt signaling through direct targeting of -catenin Evaluation of Diverse α/β-Backbone Patterns for Functional α-Helix Mimicry: Analogues of the Bim BH3 Domain Oxime side-chain cross-links in an α-helical coiled-coil protein: structure, thermodynamics, and folding-templated synthesis of bicyclic species Hydrocarbon-stapled peptides: principles, practice, and progress A general strategy to endow natural fusion-protein-derived peptides with potent antiviral activity Discovery and characterization of smORF-encoded bioactive polypeptides Chemical synthesis of hydrocarbon-stapled peptides for protein interaction research and therapeutic targeting Constraining cyclic peptides to mimic protein structure motifs.Dual-purpose linker for alpha helix stabilization and imaging agent conjugation to glucagon-like peptide-1 receptor ligands.Mechanistic and quantitative insight into cell surface targeted molecular imaging agent design.The PDB database is a rich source of alpha-helical anti-microbial peptides to combat disease causing pathogens.Truncated and helix-constrained peptides with high affinity and specificity for the cFos coiled-coil of AP-1 Truncation, randomization, and selection: generation of a reduced length c-Jun antagonist that retains high interaction stability Captides: rigid junctions between beta sheets and small molecules.Effect of hydrocarbon stapling on the properties of α-helical antimicrobial peptides isolated from the venom of hymenoptera.Increasing hydrophobicity of residues in an anti-HIV-1 Env peptide synergistically improves potency Stapled HIV-1 peptides recapitulate antigenic structures and engage broadly neutralizing antibodies.Characterizing alpha helical properties of Ebola viral proteins as potential targets for inhibition of alpha-helix mediated protein-protein interactions.Library construction, selection and modification strategies to generate therapeutic peptide-based modulators of protein-protein interactions.Novel structures of self-associating stapled peptides.Inhibitors for the Vitamin D Receptor-Coregulator Interaction.Bridged Analogues for p53-Dependent Cancer Therapy Obtained by S-Alkylation Stapling mimics noncovalent interactions of γ-carboxyglutamates in conantokins, peptidic antagonists of N-methyl-D-aspartic acid receptors A New Methodology for Incorporating Chiral Linkers into Stapled Peptides.Inhibition of caspase-9 by stabilized peptides targeting the dimerization interface.Therapeutic development in targeting protein-protein interactions with synthetic topological mimetics.A Helix-Stabilizing Linker Improves Subcutaneous Bioavailability of a Helical Peptide Independent of Linker Lipophilicity.Template-constrained macrocyclic peptides prepared from native, unprotected precursors Targeted delivery of ubiquitin-conjugated BH3 peptide-based Mcl-1 inhibitors into cancer cells A Short Double-Stapled Peptide Inhibits Respiratory Syncytial Virus Entry and Spreading.Mucosal delivery of a double-stapled RSV peptide prevents nasopulmonary infection Helix-mediated protein--protein interactions as targets for intervention using foldamers.Design and development of peptides and peptide mimetics as antagonists for therapeutic intervention.Stability of peptides and therapeutic success in cancer.Peptides and proteins as a continuing exciting source of inspiration for peptidomimetics.Going further than Lipinski's rule in drug design.Stabilized helical peptides: overview of the technologies and therapeutic promises.

P2860

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P2860

Hydrocarbon double-stapling remedies the proteolytic instability of a lengthy peptide therapeutic

http://www.wikidata.org/entity/Q34069846

description

2010 nî lūn-bûn

@nan

2010 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի հուլիսին հրատարակված գիտական հոդված

@hy

2010年の論文

@ja

2010年論文

@yue

2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

name

Hydrocarbon double-stapling re ...... a lengthy peptide therapeutic

@ast

Hydrocarbon double-stapling re ...... a lengthy peptide therapeutic

@en

Hydrocarbon double-stapling re ...... a lengthy peptide therapeutic

@nl

type

label

Hydrocarbon double-stapling re ...... a lengthy peptide therapeutic

@ast

Hydrocarbon double-stapling re ...... a lengthy peptide therapeutic

@en

Hydrocarbon double-stapling re ...... a lengthy peptide therapeutic

@nl

prefLabel

Hydrocarbon double-stapling re ...... a lengthy peptide therapeutic

@ast

Hydrocarbon double-stapling re ...... a lengthy peptide therapeutic

@en

Hydrocarbon double-stapling re ...... a lengthy peptide therapeutic

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PNAS.1002713107

P1433

Proceedings of the National Academy of Sciences of the United States of America

P1476

Hydrocarbon double-stapling re ...... a lengthy peptide therapeutic

@en

P2093

Alisa F Perry

http://www.w3.org/2001/XMLSchema#string

Amy M Princiotto

http://www.w3.org/2001/XMLSchema#string

Gregory H Bird

http://www.w3.org/2001/XMLSchema#string

Jeffrey G Supko

http://www.w3.org/2001/XMLSchema#string

Joseph G Sodroski

http://www.w3.org/2001/XMLSchema#string

Loren D Walensky

http://www.w3.org/2001/XMLSchema#string

Navid Madani

http://www.w3.org/2001/XMLSchema#string

Xiaoying He

http://www.w3.org/2001/XMLSchema#string

P2860

A stapled BID BH3 helix directly binds and activates BAX

Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix.

All-atom model for stabilization of alpha-helical structure in peptides by hydrocarbon staples.

Potent D-peptide inhibitors of HIV-1 entry

Structural characterization of the human respiratory syncytial virus fusion protein core

Short constrained peptides that inhibit HIV-1 entry

Structural and biological mimicry of protein surface recognition by / -peptide foldamers

Structure of influenza haemagglutinin at the pH of membrane fusion

Core structure of gp41 from the HIV envelope glycoprotein

Atomic structure of the ectodomain from HIV-1 gp41

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14093-14098

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scholarly article

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10.1073/PNAS.1002713107

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P433

32

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P478

107

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Evripidis Gavathiotis

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2010-07-21T00:00:00Z

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45365921

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20660316

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2922607

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