The protease inhibitor HAI-2, but not HAI-1, regulates matriptase activation and shedding through prostasin.
about
Sequence and conformational specificity in substrate recognition: several human Kunitz protease inhibitor domains are specific substrates of mesotrypsin.Matriptase zymogen supports epithelial development, homeostasis and regenerationMatriptase Complexes and Prostasin Complexes with HAI-1 and HAI-2 in Human Milk: Significant Proteolysis in LactationNatural Endogenous Human Matriptase and Prostasin Undergo Zymogen Activation via Independent Mechanisms in an Uncoupled Manner.Selective Inhibition of Prostasin in Human Enterocytes by the Integral Membrane Kunitz-Type Serine Protease Inhibitor HAI-2Matriptase-mediated cleavage of EpCAM destabilizes claudins and dysregulates intestinal epithelial homeostasis.Phosphorylation of the type II transmembrane serine protease, TMPRSS13 in Hepatocyte Growth Factor Activator Inhibitor-1 and 2-mediated cell surface localization.Hepatocyte growth factor activator inhibitor type 1 maintains the assembly of keratin into desmosomes in keratinocytes by regulating protease-activated receptor 2-dependent p38 signaling.Delineation of proteolytic and non-proteolytic functions of the membrane-anchored serine protease prostasin.The Kunitz Domain I of Hepatocyte Growth Factor Activator Inhibitor-2 Inhibits Matriptase Activity and Invasive Ability of Human Prostate Cancer Cells.Inflammatory cytokines down-regulate the barrier-protective prostasin-matriptase proteolytic cascade early in experimental colitis.HAI-2 stabilizes, inhibits and regulates SEA-cleavage-dependent secretory transport of matriptase.Loss of HAI-2 in mice with decreased prostasin activity leads to an early-onset intestinal failure resembling congenital tufting enteropathy.Hepatocyte growth factor activator inhibitor type-2 (HAI-2)/SPINT2 contributes to invasive growth of oral squamous cell carcinoma cells.
P2860
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P2860
The protease inhibitor HAI-2, but not HAI-1, regulates matriptase activation and shedding through prostasin.
description
2014 nî lūn-bûn
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2014 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2014年の論文
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2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
The protease inhibitor HAI-2, ...... nd shedding through prostasin.
@ast
The protease inhibitor HAI-2, ...... nd shedding through prostasin.
@en
The protease inhibitor HAI-2, ...... nd shedding through prostasin.
@nl
type
label
The protease inhibitor HAI-2, ...... nd shedding through prostasin.
@ast
The protease inhibitor HAI-2, ...... nd shedding through prostasin.
@en
The protease inhibitor HAI-2, ...... nd shedding through prostasin.
@nl
prefLabel
The protease inhibitor HAI-2, ...... nd shedding through prostasin.
@ast
The protease inhibitor HAI-2, ...... nd shedding through prostasin.
@en
The protease inhibitor HAI-2, ...... nd shedding through prostasin.
@nl
P2093
P2860
P356
P1476
The protease inhibitor HAI-2, ...... nd shedding through prostasin.
@en
P2093
Hiroaki Kataoka
Jeffrey Martin Schafer
Katiuchia Uzzun Sales
Lotte K Vogel
Stine Friis
P2860
P304
22319-22332
P356
10.1074/JBC.M114.574400
P407
P577
2014-06-24T00:00:00Z