Matriptase Complexes and Prostasin Complexes with HAI-1 and HAI-2 in Human Milk: Significant Proteolysis in Lactation
about
Natural Endogenous Human Matriptase and Prostasin Undergo Zymogen Activation via Independent Mechanisms in an Uncoupled Manner.Selective Inhibition of Prostasin in Human Enterocytes by the Integral Membrane Kunitz-Type Serine Protease Inhibitor HAI-2Matriptase and prostasin are expressed in human skin in an inverse trend over the course of differentiation and are targeted to different regions of the plasma membrane.Delineation of proteolytic and non-proteolytic functions of the membrane-anchored serine protease prostasin.Matriptase shedding is closely coupled with matriptase zymogen activation and requires de novo proteolytic cleavage likely involving its own activity.The type II transmembrane serine protease matriptase cleaves the amyloid precursor protein and reduces its processing to β amyloid.Tissue distribution and subcellular localizations determine in vivo functional relationship among prostasin, matriptase, HAI-1, and HAI-2 in human skin.Hepatocyte growth factor activator inhibitor type-2 (HAI-2)/SPINT2 contributes to invasive growth of oral squamous cell carcinoma cells.
P2860
Q36217915-0859A847-5D91-42F6-BBC4-6BD11C6584B1Q36261355-E6EB49CD-8A58-404B-9380-6D292D2DAF57Q37381333-B7B0C9AE-FBF3-4EC1-8638-AEEAC681307AQ39626361-385A45B5-3950-48DC-BA40-F2084E0F1F09Q41492870-4ACE4F73-6D64-415C-BDB4-93F28A3107CFQ42778244-92A02DBD-ECA4-4EDA-8621-DEB10B9422D5Q50041747-B67555A5-11FB-4B10-B39F-5BDC69985539Q55343941-F05D6DEA-4D9D-48F4-A5F3-D9E3D40A7E54
P2860
Matriptase Complexes and Prostasin Complexes with HAI-1 and HAI-2 in Human Milk: Significant Proteolysis in Lactation
description
2016 nî lūn-bûn
@nan
2016年の論文
@ja
2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
2016年论文
@zh
2016年论文
@zh-cn
name
Matriptase Complexes and Prost ...... icant Proteolysis in Lactation
@ast
Matriptase Complexes and Prost ...... icant Proteolysis in Lactation
@en
type
label
Matriptase Complexes and Prost ...... icant Proteolysis in Lactation
@ast
Matriptase Complexes and Prost ...... icant Proteolysis in Lactation
@en
prefLabel
Matriptase Complexes and Prost ...... icant Proteolysis in Lactation
@ast
Matriptase Complexes and Prost ...... icant Proteolysis in Lactation
@en
P2093
P2860
P1433
P1476
Matriptase Complexes and Prost ...... icant Proteolysis in Lactation
@en
P2093
Chen-Yong Lin
Chih-Hsin Lai
Chun-Che Tseng
Feng-Pai Chou
Hsiang-Hua D Chang
Jehng-Kang Wang
Michael D Johnson
Ying-Jung J Lai
P2860
P304
P356
10.1371/JOURNAL.PONE.0152904
P407
P577
2016-04-04T00:00:00Z