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Small molecule disruption of G beta gamma signaling inhibits the progression of heart failure

Small molecule disruption of G beta gamma signaling inhibits the progression of heart failure

http://www.wikidata.org/entity/Q34077136

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Understanding molecular recognition by G protein βγ subunits on the path to pharmacological targeting Cardiac cAMP: production, hydrolysis, modulation and detection Ongoing controversies surrounding cardiac remodeling: is it black and white-or rather fifty shades of gray?Signaling effectors underlying pathologic growth and remodeling of the heart Targeting G protein coupled receptor-related pathways as emerging molecular therapies GRK2 in the heart: a GPCR kinase and beyond Nuclear GPCRs in cardiomyocytes: an insider's view of β-adrenergic receptor signaling Paroxetine Is a Direct Inhibitor of G Protein-Coupled Receptor Kinase 2 and Increases Myocardial Contractility "Freeze, Don't Move": How to Arrest a Suspect in Heart Failure - A Review on Available GRK2 Inhibitors Inhibition of G-protein βγ signaling enhances T cell receptor-stimulated interleukin 2 transcription in CD4+ T helper cells The expanding GRK interactome: Implications in cardiovascular disease and potential for therapeutic development.New approaches in small animal echocardiography: imaging the sounds of silence.G protein-coupled Receptor Kinase 2 as a Therapeutic Target for Heart Failure.A chemical biology approach demonstrates G protein βγ subunits are sufficient to mediate directional neutrophil chemotaxis.G-protein βγ subunit dimers modulate kidney repair after ischemia-reperfusion injury in rats.Melanopsin mediates light-dependent relaxation in blood vessels.Rational design of a selective covalent modifier of G protein βγ subunits.Targeting G protein-coupled receptor kinases (GRKs) in Heart Failure.G protein modulation of CaV2 voltage-gated calcium channels Direct-reversible binding of small molecules to G protein βγ subunits.G protein coupled receptor kinases as therapeutic targets in cardiovascular disease.G protein βγ subunits regulate cardiomyocyte hypertrophy through a perinuclear Golgi phosphatidylinositol 4-phosphate hydrolysis pathway.Constitutively active signaling by the G protein βγ-subunit mediates intrinsically increased phosphodiesterase-4 activity in human asthmatic airway smooth muscle cells.The WD40 repeat protein WDR26 binds Gβγ and promotes Gβγ-dependent signal transduction and leukocyte migration G-protein βγ subunits are positive regulators of Kv7.4 and native vascular Kv7 channel activity.GRK2-mediated inhibition of adrenergic and dopaminergic signaling in right ventricular hypertrophy: therapeutic implications in pulmonary hypertension.G Protein βγ-subunit signaling mediates airway hyperresponsiveness and inflammation in allergic asthma.Repeated Mu-Opioid Exposure Induces a Novel Form of the Hyperalgesic Priming Model for Transition to Chronic Pain.G-protein βγ subunits in vasorelaxing and anti-endothelinergic effects of calcitonin gene-related peptide Paroxetine-mediated GRK2 inhibition reverses cardiac dysfunction and remodeling after myocardial infarction Noradrenaline stimulates cell proliferation by suppressing potassium channels via G(i/o) -protein-coupled α(1B) -adrenoceptors in human osteoblasts.Cardiac Fibrosis: The Fibroblast Awakens Inhibition of G-Protein βγ Signaling Decreases Levels of Messenger RNAs Encoding Proinflammatory Cytokines in T Cell Receptor-Stimulated CD4(+) T Helper Cells.WDR26 functions as a scaffolding protein to promote Gβγ-mediated phospholipase C β2 (PLCβ2) activation in leukocytes.New paradigms in GPCR drug discovery.Cardiac overexpression of Mammalian enabled (Mena) exacerbates heart failure in mice.GRK 2 level in peripheral blood lymphocytes of elderly patients with acute myocardial infarction A peptide of the RGS domain of GRK2 binds and inhibits Gα(q) to suppress pathological cardiac hypertrophy and dysfunction.Taking the heart failure battle inside the cell: small molecule targeting of Gβγ subunits G protein-dependent and G protein-independent signaling pathways and their impact on cardiac function.

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Small molecule disruption of G beta gamma signaling inhibits the progression of heart failure

http://www.wikidata.org/entity/Q34077136

description

2010 nî lūn-bûn

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2010 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2010 թվականի հունիսին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

Small molecule disruption of G ...... e progression of heart failure

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Small molecule disruption of G ...... e progression of heart failure

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Small molecule disruption of G ...... e progression of heart failure

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Small molecule disruption of G ...... e progression of heart failure

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Small molecule disruption of G ...... e progression of heart failure

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Small molecule disruption of G ...... e progression of heart failure

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Small molecule disruption of G ...... e progression of heart failure

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Small molecule disruption of G ...... e progression of heart failure

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Small molecule disruption of G ...... e progression of heart failure

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CIRCRESAHA.110.217075

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Circulation Research

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Small molecule disruption of G ...... e progression of heart failure

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Alan V Smrcka

http://www.w3.org/2001/XMLSchema#string

Alessandra Matavel

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Andrew R Pistner

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Burns C Blaxall

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Coeli M B Lopes

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Dmitriy Migdalovich

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Frances E Nwakanma

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Gabriel Vorobiof

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Liam M Casey

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Olga Dunaevsky

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P2860

ACC/AHA 2005 Guideline Update for the Diagnosis and Management of Chronic Heart Failure in the Adult: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Update the 2001 G

Targeted beta-adrenergic receptor kinase (betaARK1) inhibition by gene transfer in failing human hearts

Expression of a beta-adrenergic receptor kinase 1 inhibitor prevents the development of myocardial failure in gene-targeted mice

Heart disease and stroke statistics--2009 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee

Cardiac function in mice overexpressing the beta-adrenergic receptor kinase or a beta ARK inhibitor

Activation of heterotrimeric G proteins by a high energy phosphate transfer via nucleoside diphosphate kinase (NDPK) B and Gbeta subunits. Specific activation of Gsalpha by an NDPK B.Gbetagamma complex in H10 cells

G protein-coupled receptor kinase 2 ablation in cardiac myocytes before or after myocardial infarction prevents heart failure.

Differential targeting of Gbetagamma-subunit signaling with small molecules.

Role of beta gamma subunits of G proteins in targeting the beta-adrenergic receptor kinase to membrane-bound receptors.

Phosphorylation of G protein-coupled receptors: GPCR kinases in heart disease.

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532-539

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10.1161/CIRCRESAHA.110.217075

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4

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107

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2010-06-24T00:00:00Z

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