Small molecule disruption of G beta gamma signaling inhibits the progression of heart failure
about
Understanding molecular recognition by G protein βγ subunits on the path to pharmacological targetingCardiac cAMP: production, hydrolysis, modulation and detectionOngoing controversies surrounding cardiac remodeling: is it black and white-or rather fifty shades of gray?Signaling effectors underlying pathologic growth and remodeling of the heartTargeting G protein coupled receptor-related pathways as emerging molecular therapiesGRK2 in the heart: a GPCR kinase and beyondNuclear GPCRs in cardiomyocytes: an insider's view of β-adrenergic receptor signalingParoxetine Is a Direct Inhibitor of G Protein-Coupled Receptor Kinase 2 and Increases Myocardial Contractility"Freeze, Don't Move": How to Arrest a Suspect in Heart Failure - A Review on Available GRK2 InhibitorsInhibition of G-protein βγ signaling enhances T cell receptor-stimulated interleukin 2 transcription in CD4+ T helper cellsThe expanding GRK interactome: Implications in cardiovascular disease and potential for therapeutic development.New approaches in small animal echocardiography: imaging the sounds of silence.G protein-coupled Receptor Kinase 2 as a Therapeutic Target for Heart Failure.A chemical biology approach demonstrates G protein βγ subunits are sufficient to mediate directional neutrophil chemotaxis.G-protein βγ subunit dimers modulate kidney repair after ischemia-reperfusion injury in rats.Melanopsin mediates light-dependent relaxation in blood vessels.Rational design of a selective covalent modifier of G protein βγ subunits.Targeting G protein-coupled receptor kinases (GRKs) in Heart Failure.G protein modulation of CaV2 voltage-gated calcium channelsDirect-reversible binding of small molecules to G protein βγ subunits.G protein coupled receptor kinases as therapeutic targets in cardiovascular disease.G protein βγ subunits regulate cardiomyocyte hypertrophy through a perinuclear Golgi phosphatidylinositol 4-phosphate hydrolysis pathway.Constitutively active signaling by the G protein βγ-subunit mediates intrinsically increased phosphodiesterase-4 activity in human asthmatic airway smooth muscle cells.The WD40 repeat protein WDR26 binds Gβγ and promotes Gβγ-dependent signal transduction and leukocyte migrationG-protein βγ subunits are positive regulators of Kv7.4 and native vascular Kv7 channel activity.GRK2-mediated inhibition of adrenergic and dopaminergic signaling in right ventricular hypertrophy: therapeutic implications in pulmonary hypertension.G Protein βγ-subunit signaling mediates airway hyperresponsiveness and inflammation in allergic asthma.Repeated Mu-Opioid Exposure Induces a Novel Form of the Hyperalgesic Priming Model for Transition to Chronic Pain.G-protein βγ subunits in vasorelaxing and anti-endothelinergic effects of calcitonin gene-related peptideParoxetine-mediated GRK2 inhibition reverses cardiac dysfunction and remodeling after myocardial infarctionNoradrenaline stimulates cell proliferation by suppressing potassium channels via G(i/o) -protein-coupled α(1B) -adrenoceptors in human osteoblasts.Cardiac Fibrosis: The Fibroblast AwakensInhibition of G-Protein βγ Signaling Decreases Levels of Messenger RNAs Encoding Proinflammatory Cytokines in T Cell Receptor-Stimulated CD4(+) T Helper Cells.WDR26 functions as a scaffolding protein to promote Gβγ-mediated phospholipase C β2 (PLCβ2) activation in leukocytes.New paradigms in GPCR drug discovery.Cardiac overexpression of Mammalian enabled (Mena) exacerbates heart failure in mice.GRK 2 level in peripheral blood lymphocytes of elderly patients with acute myocardial infarctionA peptide of the RGS domain of GRK2 binds and inhibits Gα(q) to suppress pathological cardiac hypertrophy and dysfunction.Taking the heart failure battle inside the cell: small molecule targeting of Gβγ subunitsG protein-dependent and G protein-independent signaling pathways and their impact on cardiac function.
P2860
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P2860
Small molecule disruption of G beta gamma signaling inhibits the progression of heart failure
description
2010 nî lūn-bûn
@nan
2010 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Small molecule disruption of G ...... e progression of heart failure
@ast
Small molecule disruption of G ...... e progression of heart failure
@en
Small molecule disruption of G ...... e progression of heart failure
@nl
type
label
Small molecule disruption of G ...... e progression of heart failure
@ast
Small molecule disruption of G ...... e progression of heart failure
@en
Small molecule disruption of G ...... e progression of heart failure
@nl
prefLabel
Small molecule disruption of G ...... e progression of heart failure
@ast
Small molecule disruption of G ...... e progression of heart failure
@en
Small molecule disruption of G ...... e progression of heart failure
@nl
P2093
P2860
P1433
P1476
Small molecule disruption of G ...... e progression of heart failure
@en
P2093
Alan V Smrcka
Alessandra Matavel
Andrew R Pistner
Burns C Blaxall
Coeli M B Lopes
Dmitriy Migdalovich
Frances E Nwakanma
Gabriel Vorobiof
Liam M Casey
Olga Dunaevsky
P2860
P304
P356
10.1161/CIRCRESAHA.110.217075
P577
2010-06-24T00:00:00Z