Design and Applications of Bifunctional Small Molecules: Why Two Heads Are Better Than One. - Wikidata - wikimedia - TriplyDB

Design and Applications of Bifunctional Small Molecules: Why Two Heads Are Better Than One.

Design and Applications of Bifunctional Small Molecules: Why Two Heads Are Better Than One.

http://www.wikidata.org/entity/Q34077604

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Malachite Green Mediates Homodimerization of Antibody VL Domains to Form a Fluorescent Ternary Complex with Singular Symmetric Interfaces Re-engineering protein interfaces yields copper-inducible ferritin cage assembly An antibody-recruiting small molecule that targets HIV gp120.A coiled-coil enabled split-luciferase three-hybrid system: applied toward profiling inhibitors of protein kinases.Natural products as chemical probes Deciphering the kinetic binding mechanism of dimeric ligands using a potent plasma-stable dimeric inhibitor of postsynaptic density protein-95 as an example.Nucleating the assembly of macromolecular complexes.High-throughput screening for modulators of protein-protein interactions: use of photonic crystal biosensors and complementary technologies.Three steps in one pot: biosynthesis of 4-hydroxycinnamyl alcohols using immobilized whole cells of two genetically engineered Escherichia coli strains.Targeting protein-protein interactions for therapeutic intervention: a challenge for the future.Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4.Design of a PDZbody, a bivalent binder of the E6 protein from human papillomavirus Small-Molecule-Mediated Degradation of the Androgen Receptor through Hydrophobic Tagging Overexpression of artificially fused bifunctional enzyme 4CL1-CCR: a method for production of secreted 4-hydroxycinnamaldehydes in Escherichia coli.Direct Chemical Activation of a Rationally Engineered Signaling Enzyme Synthesis, cellular evaluation, and mechanism of action of piperlongumine analogs.Designed compounds for recognition of 10 base pairs of DNA with two at binding sites.On-Demand Targeting: Investigating Biology with Proximity-Directed Chemistry.Posttranslational protein knockdown coupled to receptor tyrosine kinase activation with phosphoPROTACs.Metabolic mechanisms of epigenetic regulation.Designing customized cell signalling circuits Small-molecule control of intracellular protein levels through modulation of the ubiquitin proteasome system Privileged Electrophile Sensors: A Resource for Covalent Drug Development.Go in! Go out! Inducible control of nuclear localization.Peptidyl-Proline Isomerases (PPIases): Targets for Natural Products and Natural Product-Inspired Compounds.Novel naphthalimide-benzoic acid conjugates as potential apoptosis-inducing agents: design, synthesis, and biological activity.Impact of linker length on the activity of PROTACs.A modular approach to triazole-containing chemical inducers of dimerisation for yeast three-hybrid screening.Protein Degradation by In-Cell Self-Assembly of Proteolysis Targeting Chimeras.Selective Targeting of Cells via Bispecific Molecules That Exploit Coexpression of Two Intracellular Proteins.Cell-permeant and photocleavable chemical inducer of dimerization.Designing new cellular signaling pathways.Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation.Live-Cell Protein Sulfonylation Based on Proximity-driven N-Sulfonyl Pyridone Chemistry.Decomposing Dynamical Couplings in Mutated scFv Antibody Fragments into Stabilizing and Destabilizing Effects.Artificial signal transduction therapy: a futuristic approach to disease treatment.Novel Selective Estrogen Receptor Ligand Conjugates Incorporating Endoxifen-Combretastatin and Cyclofenil-Combretastatin Hybrid Scaffolds: Synthesis and Biochemical Evaluation.An intein-cassette integration approach used for the generation of a split TEV protease activated by conditional protein splicing.Mimicking the Function of Signaling Proteins: Toward Artificial Signal Transduction Therapy.

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P2860

Design and Applications of Bifunctional Small Molecules: Why Two Heads Are Better Than One.

http://www.wikidata.org/entity/Q34077604

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2008 nî lūn-bûn

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2008 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

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2008 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2008年の論文

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2008年论文

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Design and Applications of Bif ...... Two Heads Are Better Than One.

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Design and Applications of Bif ...... Two Heads Are Better Than One.

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Design and Applications of Bif ...... Two Heads Are Better Than One.

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ACS Chemical Biology

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Design and Applications of Bif ...... Two Heads Are Better Than One.

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Craig M Crews

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Nicholas Aberle

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Timothy W Corson

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P2860

Controlling protein association and subcellular localization with a synthetic ligand that induces heterodimerization of proteins

The atypical PKC-interacting protein p62 channels NF-kappaB activation by the IL-1-TRAF6 pathway

The anti-angiogenic agent fumagillin covalently binds and inhibits the methionine aminopeptidase, MetAP-2

Crystal structure of ARF1*Sec7 complexed with Brefeldin A and its implications for the guanine nucleotide exchange mechanism

Reaching for high-hanging fruit in drug discovery at protein-protein interfaces

Small-molecule inhibitors of protein-protein interactions: progressing towards the dream

Synthesis of a beta-estradiol-biotin chimera that potently heterodimerizes estrogen receptor and streptavidin proteins in a yeast three-hybrid system.

Directed evolution of a glycosynthase via chemical complementation.

The rapamycin-binding domain of the protein kinase mammalian target of rapamycin is a destabilizing domain.

Small-molecule based delivery systems for alkylating antineoplastic compounds.

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677-692

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10.1021/CB8001792

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11

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3

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2008-11-01T00:00:00Z

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23709332

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19112665

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2925120

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