Phosphorylation of IRF4 by ROCK2 regulates IL-17 and IL-21 production and the development of autoimmunity in mice. - Wikidata - wikimedia - TriplyDB

Phosphorylation of IRF4 by ROCK2 regulates IL-17 and IL-21 production and the development of autoimmunity in mice.

Phosphorylation of IRF4 by ROCK2 regulates IL-17 and IL-21 production and the development of autoimmunity in mice.

http://www.wikidata.org/entity/Q34090173

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Recent advances in understanding the molecular mechanisms of the development and function of Th17 cells Targeted inhibition of STATs and IRFs as a potential treatment strategy in cardiovascular disease Targeting Th17 Cells with Small Molecules and Small Interference RNA Disturbed T Cell Signaling and Altered Th17 and Regulatory T Cell Subsets in the Pathogenesis of Systemic Lupus Erythematosus Regulation of IL-17 in autoimmune diseases by transcriptional factors and microRNAs ROCKs as immunomodulators of stroke Small molecules in the treatment of systemic lupus erythematosus Genetic requirements for the development and differentiation of interleukin-17-producing γδ T cells The RhoA-ROCK pathway in the regulation of T and B cell responses Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity.The etiology of paraneoplastic autoimmunity.Minireview: Glucocorticoids in autoimmunity: unexpected targets and mechanisms.Cutting Edge: Selective Oral ROCK2 Inhibitor Reduces Clinical Scores in Patients with Psoriasis Vulgaris and Normalizes Skin Pathology via Concurrent Regulation of IL-17 and IL-10 ITK signalling via the Ras/IRF4 pathway regulates the development and function of Tr1 cells.Deficiency of the G protein Gαq ameliorates experimental autoimmune encephalomyelitis with impaired DC-derived IL-6 production and Th17 differentiation Advances in kinase inhibition: treating rheumatic diseases and beyond.NOD2 downregulates colonic inflammation by IRF4-mediated inhibition of K63-linked polyubiquitination of RICK and TRAF6.Helper T cell plasticity: impact of extrinsic and intrinsic signals on transcriptomes and epigenomes.Aberrant ROCK activation promotes the development of type I diabetes in NOD mice Murine models of systemic lupus erythematosus Selective oral ROCK2 inhibitor down-regulates IL-21 and IL-17 secretion in human T cells via STAT3-dependent mechanism.Stimulation of osteoclast formation by RANKL requires interferon regulatory factor-4 and is inhibited by simvastatin in a mouse model of bone loss.Abnormalities of T cell signaling in systemic lupus erythematosus.Increased rho kinase activity in temporal artery biopsies from patients with giant cell arteritis.IRF4 deficiency abrogates lupus nephritis despite enhancing systemic cytokine production Targeting lymphocyte signaling pathways as a therapeutic approach to systemic lupus erythematosus.T cells as a therapeutic target in SLE.Signal transduction pathways and transcriptional regulation in Th17 cell differentiation Advances and challenges in immunotherapy for solid organ and hematopoietic stem cell transplantation Increased expression of IRF4 and ETS1 in CD4+ cells from patients with intermittent allergic rhinitis.Regulation and function of innate and adaptive interleukin-17-producing cells Dual regulation of IRF4 function in T and B cells is required for the coordination of T-B cell interactions and the prevention of autoimmunity.T cell signaling abnormalities contribute to aberrant immune cell function and autoimmunity.Abrogation of airway hyperresponsiveness but not inflammation by rho kinase insufficiency.Modulation of innate host factors by Mycobacterium avium complex in human macrophages includes interleukin 17.IRF4-Dependent and IRF4-Independent Pathways Contribute to DC Dysfunction in Lupus.Cigarette smoke inhibits ROCK2 activation in T cells and modulates IL-22 production Cockroach allergen exposure and risk of asthma.IL-21 receptor is required for the systemic accumulation of activated B and T lymphocytes in MRL/MpJ-Fas(lpr/lpr)/J mice.Targeted Rho-associated kinase 2 inhibition suppresses murine and human chronic GVHD through a Stat3-dependent mechanism.

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Phosphorylation of IRF4 by ROCK2 regulates IL-17 and IL-21 production and the development of autoimmunity in mice.

http://www.wikidata.org/entity/Q34090173

description

2010 nî lūn-bûn

@nan

2010 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի օգոստոսին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

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2010年论文

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name

Phosphorylation of IRF4 by ROC ...... pment of autoimmunity in mice.

@ast

Phosphorylation of IRF4 by ROC ...... pment of autoimmunity in mice.

@en

Phosphorylation of IRF4 by ROC ...... pment of autoimmunity in mice.

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type

label

Phosphorylation of IRF4 by ROC ...... pment of autoimmunity in mice.

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Phosphorylation of IRF4 by ROC ...... pment of autoimmunity in mice.

@en

Phosphorylation of IRF4 by ROC ...... pment of autoimmunity in mice.

@nl

prefLabel

Phosphorylation of IRF4 by ROC ...... pment of autoimmunity in mice.

@ast

Phosphorylation of IRF4 by ROC ...... pment of autoimmunity in mice.

@en

Phosphorylation of IRF4 by ROC ...... pment of autoimmunity in mice.

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Journal of Clinical Investigation

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Phosphorylation of IRF4 by ROC ...... pment of autoimmunity in mice.

@en

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Alessandra B Pernis

http://www.w3.org/2001/XMLSchema#string

Emily Chang

http://www.w3.org/2001/XMLSchema#string

Govind Bhagat

http://www.w3.org/2001/XMLSchema#string

James K Liao

http://www.w3.org/2001/XMLSchema#string

Li Song

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Partha S Biswas

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Roslynn A Stirzaker

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Sanjay Gupta

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P2860

Rocks: multifunctional kinases in cell behaviour

Modulation of T cell cytokine production by interferon regulatory factor-4

Nuclear Rho kinase, ROCK2, targets p300 acetyltransferase

Interferon regulatory factor 4 (IRF4) interacts with NFATc2 to modulate interleukin 4 gene expression

X-ray crystal structure of IRF-3 and its functional implications

Crystal structure of IRF-3 reveals mechanism of autoinhibition and virus-induced phosphoactivation

Insights into interferon regulatory factor activation from the crystal structure of dimeric IRF5

Essential role of IL-21 in B cell activation, expansion, and plasma cell generation during CD4+ T cell-B cell collaboration

TH17 cells in development: an updated view of their molecular identity and genetic programming

Rho and Rac take center stage

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3280-3295

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10.1172/JCI42856

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9

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120

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45583591

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20697158

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phosphorylation

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2929726

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