Genome architecture of the human beta-globin locus affects developmental regulation of gene expression
about
Systematic documentation and analysis of human genetic variation in hemoglobinopathies using the microattribution approachMi2β is required for γ-globin gene silencing: temporal assembly of a GATA-1-FOG-1-Mi2 repressor complex in β-YAC transgenic miceDevelopmental and species-divergent globin switching are driven by BCL11APhylogenetic comparisons suggest that distance from the locus control region guides developmental expression of primate beta-type globin genes.LCR 5' hypersensitive site specificity for globin gene activation within the active chromatin hub.A T-to-G transversion at nucleotide -567 upstream of HBG2 in a GATA-1 binding motif is associated with elevated hemoglobin F.Persistent fetal gamma-globin expression in adult transgenic mice following deletion of two silencer elements located 3' to the human Agamma-globin gene.Silencing of Agamma-globin gene expression during adult definitive erythropoiesis mediated by GATA-1-FOG-1-Mi2 complex binding at the -566 GATA site.Identification of higher-order functional domains in the human ENCODE regions.Induction of Fetal Hemoglobin In Vivo Mediated by a Synthetic γ-Globin Zinc Finger Activator.Evidence for a bigenic chromatin subdomain in regulation of the fetal-to-adult hemoglobin switch.
P2860
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P2860
Genome architecture of the human beta-globin locus affects developmental regulation of gene expression
description
2005 nî lūn-bûn
@nan
2005 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Genome architecture of the hum ...... regulation of gene expression
@ast
Genome architecture of the hum ...... regulation of gene expression
@en
Genome architecture of the hum ...... regulation of gene expression
@nl
type
label
Genome architecture of the hum ...... regulation of gene expression
@ast
Genome architecture of the hum ...... regulation of gene expression
@en
Genome architecture of the hum ...... regulation of gene expression
@nl
prefLabel
Genome architecture of the hum ...... regulation of gene expression
@ast
Genome architecture of the hum ...... regulation of gene expression
@en
Genome architecture of the hum ...... regulation of gene expression
@nl
P2093
P2860
P1476
Genome architecture of the hum ...... regulation of gene expression
@en
P2093
George Stamatoyannopoulos
Kenneth R Peterson
Patrick A Navas
Susanna Harju
P2860
P304
P356
10.1128/MCB.25.20.8765-8778.2005
P407
P577
2005-10-01T00:00:00Z