Silencing of Agamma-globin gene expression during adult definitive erythropoiesis mediated by GATA-1-FOG-1-Mi2 complex binding at the -566 GATA site.
about
Systematic documentation and analysis of human genetic variation in hemoglobinopathies using the microattribution approachFetal globin gene repressors as drug targets for molecular therapies to treat the β-globinopathiesEpigenetic regulation of fetal globin gene expression in adult erythroid cellsHematopoietic overexpression of FOG1 does not affect B-cells but reduces the number of circulating eosinophilsMi2β is required for γ-globin gene silencing: temporal assembly of a GATA-1-FOG-1-Mi2 repressor complex in β-YAC transgenic miceIkaros interacts with P-TEFb and cooperates with GATA-1 to enhance transcription elongationPGC-1 coactivator activity is required for murine erythropoiesis.A zinc-finger transcriptional activator designed to interact with the gamma-globin gene promoters enhances fetal hemoglobin production in primary human adult erythroblastsAn international effort to cure a global health problem: A report on the 19th Hemoglobin Switching Conference.Role of the GATA-1/FOG-1/NuRD pathway in the expression of human beta-like globin genes.O-GlcNAcase Expression is Sensitive to Changes in O-GlcNAc Homeostasis.Recombinant erythroid Kruppel-like factor fused to GATA1 up-regulates delta- and gamma-globin expression in erythroid cellsGeneration of transgenic mice with megabase-sized human yeast artificial chromosomes by yeast spheroplast-embryonic stem cell fusion.Update on fetal hemoglobin gene regulation in hemoglobinopathiesNuclear receptors TR2 and TR4 recruit multiple epigenetic transcriptional corepressors that associate specifically with the embryonic β-type globin promoters in differentiated adult erythroid cells.Acetylation of histone deacetylase 1 regulates NuRD corepressor complex activityMBD2 and multiple domains of CHD4 are required for transcriptional repression by Mi-2/NuRD complexesLCR 5' hypersensitive site specificity for globin gene activation within the active chromatin hub.A T-to-G transversion at nucleotide -567 upstream of HBG2 in a GATA-1 binding motif is associated with elevated hemoglobin F.Mi2β-mediated silencing of the fetal γ-globin gene in adult erythroid cells.Original Research: Generation of non-deletional hereditary persistence of fetal hemoglobin β-globin locus yeast artificial chromosome transgenic mouse models: -175 Black HPFH and -195 Brazilian HPFHOriginal Research: Stable expression of miR-34a mediates fetal hemoglobin induction in K562 cells.O-Linked N-Acetylglucosamine (O-GlcNAc) Transferase and O-GlcNAcase Interact with Mi2β Protein at the Aγ-Globin Promoter.Transcriptional mechanisms underlying hemoglobin synthesis.Role of STAT3 and GATA-1 interactions in gamma-globin gene expression.Advances in the understanding of haemoglobin switching.Genome-wide analysis of aberrantly expressed lncRNAs and miRNAs with associated co-expression and ceRNA networks in β-thalassemia and hereditary persistence of fetal hemoglobin.siDNMT1 increases γ-globin expression in chemical inducer of dimerization (CID)-dependent mouse βYAC bone marrow cells and in baboon erythroid progenitor cell cultures.CTCF demarcates chicken embryonic α-globin gene autonomous silencing and contributes to adult stage-specific gene expressionInduction of Fetal Hemoglobin In Vivo Mediated by a Synthetic γ-Globin Zinc Finger Activator.Extensively self-renewing erythroblasts derived from transgenic β-yac mice is a novel model system for studying globin switching and erythroid maturation.NuRD mediates activating and repressive functions of GATA-1 and FOG-1 during blood development.Ikaros and GATA-1 combinatorial effect is required for silencing of human gamma-globin genes.Pharmacological and molecular approaches for the treatment of β-hemoglobin disorders.The intrinsic genetic and epigenetic regulator factors as therapeutic targets, and the effect on fetal globin gene expression.Mbd2-CP2c loop drives adult-type globin gene expression and definitive erythropoiesis.
P2860
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P2860
Silencing of Agamma-globin gene expression during adult definitive erythropoiesis mediated by GATA-1-FOG-1-Mi2 complex binding at the -566 GATA site.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh
2008年學術文章
@zh-hant
name
Silencing of Agamma-globin gen ...... binding at the -566 GATA site.
@en
type
label
Silencing of Agamma-globin gen ...... binding at the -566 GATA site.
@en
prefLabel
Silencing of Agamma-globin gen ...... binding at the -566 GATA site.
@en
P2093
P2860
P356
P1476
Silencing of Agamma-globin gen ...... binding at the -566 GATA site
@en
P2093
Flávia C Costa
Halyna Fedosyuk
Kenneth R Peterson
Renee Neades
P2860
P304
P356
10.1128/MCB.01858-07
P407
P577
2008-03-17T00:00:00Z