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Selective inhibition of BET bromodomainsA chemical probe selectively inhibits G9a and GLP methyltransferase activity in cellsStructural biology and chemistry of protein arginine methyltransferasesOpen access chemical probes for epigenetic targetsDirect and Propagated Effects of Small Molecules on Protein-Protein Interaction NetworksChemical probes of histone lysine methyltransferasesAdvancing Biological Understanding and Therapeutics Discovery with Small-Molecule ProbesCurrent chemical biology approaches to interrogate protein methyltransferasesSmall-Molecule Ligands of Methyl-Lysine Binding ProteinsStructurally Sophisticated Octahedral Metal Complexes as Highly Selective Protein Kinase InhibitorsFamily-wide chemical profiling and structural analysis of PARP and tankyrase inhibitorsStructural analysis of human KDM5B guides histone demethylase inhibitor developmentPubChem as a public resource for drug discoveryBET bromodomain inhibition as a therapeutic strategy to target c-MycContributions of academic laboratories to the discovery and development of chemical biology toolsSelectivity Profiling and Biological Activity of Novel β-Carbolines as Potent and Selective DYRK1 Kinase InhibitorsInvestigating Apoptozole as a Chemical Probe for HSP70 InhibitionA High-Throughput Screening-Compatible Strategy for the Identification of Inositol Pyrophosphate Kinase InhibitorsAssessing the mechanism and therapeutic potential of modulators of the human Mediator complex-associated protein kinasesIs Open Science the Future of Drug Development?Small Molecule Inhibitor of CBFβ-RUNX Binding for RUNX Transcription Factor Driven CancersChemical biology. A small-molecule inhibitor of the aberrant transcription factor CBFβ-SMMHC delays leukemia in mice.A cellular chemical probe targeting the chromodomains of Polycomb repressive complex 1Identification of non-peptide malignant brain tumor (MBT) repeat antagonists by virtual screening of commercially available compounds.Accessing protein methyltransferase and demethylase enzymology using microfluidic capillary electrophoresishCB2 ligand-interaction landscape: cysteine residues critical to biarylpyrazole antagonist binding motif and receptor modulation.Chemical probes targeting epigenetic proteins: Applications beyond oncology.Choose and Use Your Chemical Probe Wisely to Explore Cancer Biology.Branching cascades: a concise synthetic strategy targeting diverse and complex molecular frameworks.Composition and applications of focus libraries to phenotypic assaysThe estrogen-related receptor α inverse agonist XCT 790 is a nanomolar mitochondrial uncouplerHigh-throughput kinase profiling: a more efficient approach toward the discovery of new kinase inhibitors.Probing the probes: fitness factors for small molecule tools.The use of small molecules in somatic-cell reprogramming.Protein lysine methyltransferase G9a inhibitors: design, synthesis, and structure activity relationships of 2,4-diamino-7-aminoalkoxy-quinazolines.Biology-oriented synthesis.PubChem promiscuity: a web resource for gathering compound promiscuity data from PubChem.UNC2025, a potent and orally bioavailable MER/FLT3 dual inhibitor.Towards patient-based cancer therapeutics.(R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells.
P2860
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P2860
description
2010 nî lūn-bûn
@nan
2010 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի մարտին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
The art of the chemical probe.
@ast
The art of the chemical probe.
@en
The art of the chemical probe.
@nl
type
label
The art of the chemical probe.
@ast
The art of the chemical probe.
@en
The art of the chemical probe.
@nl
prefLabel
The art of the chemical probe.
@ast
The art of the chemical probe.
@en
The art of the chemical probe.
@nl
P356
P1476
The art of the chemical probe.
@en
P2093
Stephen V Frye
P2888
P304
P356
10.1038/NCHEMBIO.296
P577
2010-03-01T00:00:00Z