Predicting cardiomyopathic phenotypes by altering Ca2+ affinity of cardiac troponin C.

Predicting cardiomyopathic phenotypes by altering Ca2+ affinity of cardiac troponin C.

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http://www.wikidata.org/entity/Q34107285
Molecular basis of calcium-sensitizing and desensitizing mutations of the human cardiac troponin C regulatory domain: a multi-scale simulation studyGenetics and disease of ventricular muscle.Cardiac Troponin and Tropomyosin: Structural and Cellular Perspectives to Unveil the Hypertrophic Cardiomyopathy PhenotypeWhy Is there a Limit to the Changes in Myofilament Ca2+-Sensitivity Associated with Myopathy Causing Mutations?A mutation in TNNC1-encoded cardiac troponin C, TNNC1-A31S, predisposes to hypertrophic cardiomyopathy and ventricular fibrillationMolecular determinants of cardiac myocyte performance as conferred by isoform-specific TnI residuesPKA phosphorylation of cardiac troponin I modulates activation and relaxation kinetics of ventricular myofibrils.Functional characterization of TNNC1 rare variants identified in dilated cardiomyopathy.Fluorescent Protein-Based Ca2+ Sensor Reveals Global, Divalent Cation-Dependent Conformational Changes in Cardiac Troponin CIn Vivo Analysis of Troponin C Knock-In (A8V) Mice: Evidence that TNNC1 Is a Hypertrophic Cardiomyopathy Susceptibility GeneStructural and functional consequences of the cardiac troponin C L48Q Ca(2+)-sensitizing mutation.Long-timescale molecular dynamics simulations elucidate the dynamics and kinetics of exposure of the hydrophobic patch in troponin CStructural and functional consequences of cardiac troponin C L57Q and I61Q Ca(2+)-desensitizing variantsA Tension-Based Model Distinguishes Hypertrophic versus Dilated Cardiomyopathy.Sarcomere neutralization in inherited cardiomyopathy: small-molecule proof-of-concept to correct hyper-Ca2+-sensitive myofilamentsCardiac troponin structure-function and the influence of hypertrophic cardiomyopathy associated mutations on modulation of contractility.Probing the mechanism of cardiovascular drugs using a covalent levosimendan analog.
P2860

Predicting cardiomyopathic phenotypes by altering Ca2+ affinity of cardiac troponin C.

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http://www.wikidata.org/entity/Q34107285
description
2010 nî lūn-bûn
@nan
2010 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Predicting cardiomyopathic phenotypes by altering Ca2+ affinity of cardiac troponin C.
@ast
Predicting cardiomyopathic phenotypes by altering Ca2+ affinity of cardiac troponin C.
@en
Predicting cardiomyopathic phenotypes by altering Ca2+ affinity of cardiac troponin C.
@nl
type
label
Predicting cardiomyopathic phenotypes by altering Ca2+ affinity of cardiac troponin C.
@ast
Predicting cardiomyopathic phenotypes by altering Ca2+ affinity of cardiac troponin C.
@en
Predicting cardiomyopathic phenotypes by altering Ca2+ affinity of cardiac troponin C.
@nl
prefLabel
Predicting cardiomyopathic phenotypes by altering Ca2+ affinity of cardiac troponin C.
@ast
Predicting cardiomyopathic phenotypes by altering Ca2+ affinity of cardiac troponin C.
@en
Predicting cardiomyopathic phenotypes by altering Ca2+ affinity of cardiac troponin C.
@nl
P1433
P1476
P2093
P2860
P304
P31
P356
P407
P433
P478
P577
P698
P932
P356
P1433
P1476
Predicting cardiomyopathic phenotypes by altering Ca2+ affinity of cardiac troponin C.
@en
P2093
P2860
P304
P31
P356
P407
P433
P478
P577
P698
P932