Kinetic properties of p53 phosphorylation by the human vaccinia-related kinase 1.
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Macro histone H2A1.2 (macroH2A1) protein suppresses mitotic kinase VRK1 during interphaseCharacterization of three paralogous members of the Mammalian vaccinia related kinase familyNMR solution structure of human vaccinia-related kinase 1 (VRK1) reveals the C-terminal tail essential for its structural stability and autocatalytic activityHuman VRK2 (vaccinia-related kinase 2) modulates tumor cell invasion by hyperactivation of NFAT1 and expression of cyclooxygenase-2c-Jun phosphorylation by the human vaccinia-related kinase 1 (VRK1) and its cooperation with the N-terminal kinase of c-Jun (JNK)The vaccinia-related kinases phosphorylate the N' terminus of BAF, regulating its interaction with DNA and its retention in the nucleusPlk3 interacts with and specifically phosphorylates VRK1 in Ser342, a downstream target in a pathway that induces Golgi fragmentationProteomics identification of nuclear Ran GTPase as an inhibitor of human VRK1 and VRK2 (vaccinia-related kinase) activitiesp53 Stabilization and accumulation induced by human vaccinia-related kinase 1VRK1 interacts with p53 forming a basal complex that is activated by UV-induced DNA damageVaccinia-related kinase 1 (VRK1) is an upstream nucleosomal kinase required for the assembly of 53BP1 foci in response to ionizing radiation-induced DNA damageHuman vaccinia-related kinase 1 (VRK1) activates the ATF2 transcriptional activity by novel phosphorylation on Thr-73 and Ser-62 and cooperates with JNKVaccinia-related kinase 2 modulates the stress response to hypoxia mediated by TAK1p53 downregulates its activating vaccinia-related kinase 1, forming a new autoregulatory loopMembers of a novel family of mammalian protein kinases complement the DNA-negative phenotype of a vaccinia virus ts mutant defective in the B1 kinaseBiomarkers of head and neck cancer, tools or a gordian knot?Identification of human kinases involved in hepatitis C virus replication by small interference RNA library screening.Human VRK1 is an early response gene and its loss causes a block in cell cycle progression.The C/H3 domain of p300 is required to protect VRK1 and VRK2 from their downregulation induced by p53Mice deficient in the serine/threonine protein kinase VRK1 are infertile due to a progressive loss of spermatogonia.Functional disruption of the moloney murine leukemia virus preintegration complex by vaccinia-related kinases.Identification of potential synthetic lethal genes to p53 using a computational biology approachMolecular genetic analysis of VRK1 in mammary epithelial cells: depletion slows proliferation in vitro and tumor growth and metastasis in vivo.Defective p53 post-translational modification required for wild type p53 inactivation in malignant epithelial cells with mdm2 gene amplification.Structural characterization of human Vaccinia-Related Kinases (VRK) bound to small-molecule inhibitors identifies different P-loop conformations.VRK1 and AURKB form a complex that cross inhibit their kinase activity and the phosphorylation of histone H3 in the progression of mitosis.Sensitivity of the kinase activity of human vaccinia-related kinase proteins to toxic metals.Expression of the VRK (vaccinia-related kinase) gene family of p53 regulators in murine hematopoietic development.Overexpression of the VRK1 kinase, which is associated with breast cancer, induces a mesenchymal to epithelial transition in mammary epithelial cells
P2860
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P2860
Kinetic properties of p53 phosphorylation by the human vaccinia-related kinase 1.
description
2002 nî lūn-bûn
@nan
2002 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի մարտին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Kinetic properties of p53 phosphorylation by the human vaccinia-related kinase 1.
@ast
Kinetic properties of p53 phosphorylation by the human vaccinia-related kinase 1.
@en
Kinetic properties of p53 phosphorylation by the human vaccinia-related kinase 1.
@nl
type
label
Kinetic properties of p53 phosphorylation by the human vaccinia-related kinase 1.
@ast
Kinetic properties of p53 phosphorylation by the human vaccinia-related kinase 1.
@en
Kinetic properties of p53 phosphorylation by the human vaccinia-related kinase 1.
@nl
prefLabel
Kinetic properties of p53 phosphorylation by the human vaccinia-related kinase 1.
@ast
Kinetic properties of p53 phosphorylation by the human vaccinia-related kinase 1.
@en
Kinetic properties of p53 phosphorylation by the human vaccinia-related kinase 1.
@nl
P2093
P356
P1476
Kinetic properties of p53 phosphorylation by the human vaccinia-related kinase 1.
@en
P2093
Francisco M Vega
Pedro A Lazo
Ramiro Barcia
Susana López-Borges
P356
10.1006/ABBI.2001.2746
P407
P577
2002-03-01T00:00:00Z