Rictor forms a complex with Cullin-1 to promote SGK1 ubiquitination and destruction. - Wikidata - wikimedia - TriplyDB

Rictor forms a complex with Cullin-1 to promote SGK1 ubiquitination and destruction.

Rictor forms a complex with Cullin-1 to promote SGK1 ubiquitination and destruction.

http://www.wikidata.org/entity/Q34125987

about

mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide Rictor regulates FBXW7-dependent c-Myc and cyclin E degradation in colorectal cancer cells Sirolimus and Everolimus Pathway: Reviewing Candidate Genes Influencing Their Intracellular Effects SGK1: The Dark Side of PI3K Signaling.Mammalian target of rapamycin and Rictor control neutrophil chemotaxis by regulating Rac/Cdc42 activity and the actin cytoskeleton Specific blockade of Rictor-mTOR association inhibits mTORC2 activity and is cytotoxic in glioblastoma.Maintaining glycogen synthase kinase-3 activity is critical for mTOR kinase inhibitors to inhibit cancer cell growth.Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus Cullin-1 promotes cell proliferation via cell cycle regulation and is a novel in prostate cancer.Conditional astroglial Rictor overexpression induces malignant glioma in mice Systematic analysis of the in situ crosstalk of tyrosine modifications reveals no additional natural selection on multiply modified residues.Rictor negatively regulates high-affinity receptors for IgE-induced mast cell degranulation.Rheb1 is required for mTORC1 and myelination in postnatal brain development Frontier of epilepsy research - mTOR signaling pathway.Conditional disruption of rictor demonstrates a direct requirement for mTORC2 in skin tumor development and continued growth of established tumors Glycogen synthase kinase (GSK)-3 promotes p70 ribosomal protein S6 kinase (p70S6K) activity and cell proliferation ERK kinase phosphorylates and destabilizes the tumor suppressor FBW7 in pancreatic cancer Rictor Undergoes Glycogen Synthase Kinase 3 (GSK3)-dependent, FBXW7-mediated Ubiquitination and Proteasomal Degradation.mTOR Complex 2 Stabilizes Mcl-1 Protein by Suppressing Its Glycogen Synthase Kinase 3-Dependent and SCF-FBXW7-Mediated Degradation.Systematic Analysis of the Genetic Variability That Impacts SUMO Conjugation and Their Involvement in Human Diseases.Skp1 Independent Function of Cdc53/Cul1 in F-box Protein Homeostasis mTOR complex 2 signaling and functions CAR Suppresses Hepatic Gluconeogenesis by Facilitating the Ubiquitination and Degradation of PGC1α.PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase Complex.H2O2 regulates lung epithelial sodium channel (ENaC) via ubiquitin-like protein Nedd8.SCF-mediated Cdh1 degradation defines a negative feedback system that coordinates cell-cycle progression.Using the ubiquitin-modified proteome to monitor protein homeostasis function.Dual phosphorylation of Sin1 at T86 and T398 negatively regulates mTORC2 complex integrity and activity.pVHL suppresses kinase activity of Akt in a proline-hydroxylation-dependent manner.Mammalian TOR signaling to the AGC kinases.Therapeutic potential of serum and glucocorticoid inducible kinase inhibition.Signaling crosstalk between the mTOR complexes.SKP2 loss destabilizes EZH2 by promoting TRAF6-mediated ubiquitination to suppress prostate cancer.The mTOR pathway controls cell proliferation by regulating the FoxO3a transcription factor via SGK1 kinase.Phosphorylation of Rictor at Thr1135 impairs the Rictor/Cullin-1 complex to ubiquitinate SGK1.Rictor regulates cell migration by suppressing RhoGDI2.Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis.G-Protein Dependent Signal Transduction and Ubiquitination in Dictyostelium.Oncogenic Signalling through Mechanistic Target of Rapamycin (mTOR): A Driver of Metabolic Transformation and Cancer Progression.Multiple lines of inhibitory feedback on AKT kinase in Schwann cells lacking TSC1/2 hint at distinct functions of mTORC1 and AKT in nerve development.

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P2860

Rictor forms a complex with Cullin-1 to promote SGK1 ubiquitination and destruction.

http://www.wikidata.org/entity/Q34125987

description

2010 nî lūn-bûn

@nan

2010 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի սեպտեմբերին հրատարակված գիտական հոդված

@hy

2010年の論文

@ja

2010年論文

@yue

2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

name

Rictor forms a complex with Cullin-1 to promote SGK1 ubiquitination and destruction.

@ast

Rictor forms a complex with Cullin-1 to promote SGK1 ubiquitination and destruction.

@en

Rictor forms a complex with Cullin-1 to promote SGK1 ubiquitination and destruction.

@nl

type

label

Rictor forms a complex with Cullin-1 to promote SGK1 ubiquitination and destruction.

@ast

Rictor forms a complex with Cullin-1 to promote SGK1 ubiquitination and destruction.

@en

Rictor forms a complex with Cullin-1 to promote SGK1 ubiquitination and destruction.

@nl

prefLabel

Rictor forms a complex with Cullin-1 to promote SGK1 ubiquitination and destruction.

@ast

Rictor forms a complex with Cullin-1 to promote SGK1 ubiquitination and destruction.

@en

Rictor forms a complex with Cullin-1 to promote SGK1 ubiquitination and destruction.

@nl

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P356

J.MOLCEL.2010.08.016

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P1476

Rictor forms a complex with Cullin-1 to promote SGK1 ubiquitination and destruction.

@en

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Adriana E Tron

http://www.w3.org/2001/XMLSchema#string

Alan Lau

http://www.w3.org/2001/XMLSchema#string

Alan Tseng

http://www.w3.org/2001/XMLSchema#string

Alex Toker

http://www.w3.org/2001/XMLSchema#string

Anders H Berg

http://www.w3.org/2001/XMLSchema#string

Bo Zhai

http://www.w3.org/2001/XMLSchema#string

Daming Gao

http://www.w3.org/2001/XMLSchema#string

Eric Bennett

http://www.w3.org/2001/XMLSchema#string

Hiroyuki Inuzuka

http://www.w3.org/2001/XMLSchema#string

J Wade Harper

http://www.w3.org/2001/XMLSchema#string

P2860

A probability-based approach for high-throughput protein phosphorylation analysis and site localization

Insights into SCF ubiquitin ligases from the structure of the Skp1-Skp2 complex

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action

Sgk kinases and their role in epithelial transport

The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1

Protein phosphatase 2A dephosphorylation of phosphoserine 112 plays the gatekeeper role for BAD-mediated apoptosis

Protein kinase DYRK2 is a scaffold that facilitates assembly of an E3 ligase

mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)

P304

797-808

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scholarly article

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10.1016/J.MOLCEL.2010.08.016

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5

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39

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2010-09-01T00:00:00Z

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46219230

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20832730

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P921

protein ubiquitination

P932

2939073

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