The effect of allosteric modulators on the kinetics of agonist-G protein-coupled receptor interactions in single living cells.
about
Fluorescent approaches for understanding interactions of ligands with G protein coupled receptorsTamoxifen Isomers and Metabolites Exhibit Distinct Affinity and Activity at Cannabinoid Receptors: Potential Scaffold for Drug DevelopmentFragment screening at adenosine-A(3) receptors in living cells using a fluorescence-based binding assay.Portraying G protein-coupled receptors with fluorescent ligandsAllosteric modulation of purine and pyrimidine receptors.Allosteric interactions across native adenosine-A3 receptor homodimers: quantification using single-cell ligand-binding kinetics.The significance of G protein-coupled receptor crystallography for drug discovery.Lighting up G protein-coupled purinergic receptors with engineered fluorescent ligands.Fluorescent ligands for adenosine receptors.Fluorescence- and bioluminescence-based approaches to study GPCR ligand binding.Small-molecule-biased formyl peptide receptor agonist compound 17b protects against myocardial ischaemia-reperfusion injury in mice.Allosteric interactions at adenosine A(1) and A(3) receptors: new insights into the role of small molecules and receptor dimerization.Biophysical Detection of Diversity and Bias in GPCR Function.Synthesis and characterization of high-affinity 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene-labeled fluorescent ligands for human β-adrenoceptors.The use of fluorescence correlation spectroscopy to characterize the molecular mobility of fluorescently labelled G protein-coupled receptors.Investigation of GPCR allosterism and dimerization in single living cells using fluorescent ligands.Role of the Second Extracellular Loop of the Adenosine A1 Receptor on Allosteric Modulator Binding, Signaling, and Cooperativity.Use of a new proximity assay (NanoBRET) to investigate the ligand-binding characteristics of three fluorescent ligands to the human β1-adrenoceptor expressed in HEK-293 cells.Negative cooperativity across β1-adrenoceptor homodimers provides insights into the nature of the secondary low-affinity CGP 12177 β1-adrenoceptor binding conformation.Molecular mechanism of allosteric modulation at GPCRs: insight from a binding kinetics study at the human A1 adenosine receptor.Detection of the secondary, low-affinity β1 -adrenoceptor site in living cells using the fluorescent CGP 12177 derivative BODIPY-TMR-CGP.Kinetic analysis of antagonist-occupied adenosine-A3 receptors within membrane microdomains of individual cells provides evidence of receptor dimerization and allosterism.Fluorescent ligands for G protein-coupled receptors: illuminating receptor-ligand interactions for drug discovery.A Non-imaging High Throughput Approach to Chemical Library Screening at the Unmodified Adenosine-A3 Receptor in Living Cells.
P2860
Q27004213-A04ECC4D-C8B7-4021-931F-E8637FB69885Q28554883-C918B816-CAF1-4E07-B279-3C438F681D1AQ31100553-B7A8C1EF-0BB8-4944-BB76-1A35C0604083Q34211605-F10A3EA5-8C90-4572-814B-9324992D8995Q35190426-F1E3AA5B-42AF-4BEE-90BB-446527A57E8FQ35225057-6A231A03-B662-433E-BD17-E98FA526A08CQ35264433-1347635C-BC50-42E8-A6A3-7099321DAFF5Q36171090-C20A0355-8156-450A-A393-72D1D7B5ADC7Q36570374-1F04465E-367B-47A7-A199-1F37510FF922Q37446861-AE522560-3AD9-4D19-B30A-254FAC0063A3Q37642476-3CBB3810-BCB9-4B56-BFD7-C5AEEECF96D2Q38136285-786A963A-746C-433A-B391-17FF3B0D6BE3Q38196401-C8205C31-89DB-4E11-87A7-8505D4AF9676Q38641723-B1378837-4256-456E-A19B-376203E7C1EFQ38805872-0566448A-84B1-49CE-AA13-F6EB4B9A92C0Q39150893-B258B3DD-8108-49B7-A261-3414BF5F8694Q39341570-968C48DA-DCA6-475B-A2D6-036CFA48D602Q39428983-10696135-DBD2-41C3-BA30-FE7FE41627EEQ42149596-055F670C-C9F3-4243-A55C-F2A04BBA628DQ42221343-D8EB0F6A-3C07-4927-8CC2-B6DD401B5383Q42559814-653DC030-D88A-4F47-B11E-574A82BA6DCBQ42950461-DBA84AD5-D1CB-40B7-BFDD-C1D3D5A8A9CDQ44404761-60EEB3F5-ACE3-44FF-983C-C6E26D84C350Q49714374-53BBBF3B-24A9-4D7A-8E69-1ADA0588B2A2
P2860
The effect of allosteric modulators on the kinetics of agonist-G protein-coupled receptor interactions in single living cells.
description
2010 nî lūn-bûn
@nan
2010 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
The effect of allosteric modul ...... ctions in single living cells.
@ast
The effect of allosteric modul ...... ctions in single living cells.
@en
The effect of allosteric modul ...... ctions in single living cells.
@nl
type
label
The effect of allosteric modul ...... ctions in single living cells.
@ast
The effect of allosteric modul ...... ctions in single living cells.
@en
The effect of allosteric modul ...... ctions in single living cells.
@nl
prefLabel
The effect of allosteric modul ...... ctions in single living cells.
@ast
The effect of allosteric modul ...... ctions in single living cells.
@en
The effect of allosteric modul ...... ctions in single living cells.
@nl
P2093
P2860
P356
P1476
The effect of allosteric modul ...... ctions in single living cells.
@en
P2093
Lauren T May
Stephen J Briddon
Stephen J Hill
Tim J Self
P2860
P304
P356
10.1124/MOL.110.064493
P577
2010-06-22T00:00:00Z