Synthesis and spectrum of the neoglycoside ACHN-490 - Wikidata - wikimedia - TriplyDB

Synthesis and spectrum of the neoglycoside ACHN-490

Synthesis and spectrum of the neoglycoside ACHN-490

http://www.wikidata.org/entity/Q34134992

about

"Stormy waters ahead": global emergence of carbapenemases Breaking the Spell: Combating Multidrug Resistant 'Superbugs'Strategies to overcome the action of aminoglycoside-modifying enzymes for treating resistant bacterial infections 4′-O-substitutions determine selectivity of aminoglycoside antibiotics Clinical management of infections caused by multidrug-resistant Enterobacteriaceae Antibiotics in the clinical pipeline at the end of 2015.Discovery research: the scientific challenge of finding new antibiotics.New trends in aminoglycosides use.Carbapenem-resistant Klebsiella pneumoniae strains exhibit diversity in aminoglycoside-modifying enzymes, which exert differing effects on plazomicin and other agents.Comparison of the next-generation aminoglycoside plazomicin to gentamicin, tobramycin and amikacin.Identification and evaluation of improved 4'-O-(alkyl) 4,5-disubstituted 2-deoxystreptamines as next-generation aminoglycoside antibiotics.Investigational antimicrobial agents of 2013.The evolving role of chemical synthesis in antibacterial drug discovery.In vivo efficacy of apramycin in murine infection models.Pharmacokinetics and safety of single and multiple doses of ACHN-490 injection administered intravenously in healthy subjects Plazomicin: an investigational therapy for the treatment of urinary tract infections.The challenge of efflux-mediated antibiotic resistance in Gram-negative bacteria.In vitro activity of ceftazidime-avibactam against 338 molecularly characterized gentamicin-nonsusceptible Gram-negative clinical isolates obtained from patients in Canadian hospitals.Activity of plazomicin (ACHN-490) against MDR clinical isolates of Klebsiella pneumoniae, Escherichia coli, and Enterobacter spp. from Athens, Greece.Synthesis and Biological Activity of Mono- and Di-N-acylated Aminoglycosides.Structure-activity relationships among the kanamycin aminoglycosides: role of ring I hydroxyl and amino groups Mechanisms of Resistance to Aminoglycoside Antibiotics: Overview and Perspectives A review of patents (2011-2015) towards combating resistance to and toxicity of aminoglycosides Adaptation-based resistance to siderophore-conjugated antibacterial agents by Pseudomonas aeruginosa Understanding and overcoming aminoglycoside resistance caused by N-6'-acetyltransferase.In vitro activity of plazomicin against 5,015 gram-negative and gram-positive clinical isolates obtained from patients in canadian hospitals as part of the CANWARD study, 2011-2012.Current use of aminoglycosides: indications, pharmacokinetics and monitoring for toxicity.Status report on carbapenemases: challenges and prospects.Inhaled antibiotics for gram-negative respiratory infections.Pharmacological considerations for the proper clinical use of aminoglycosides.Antibiotics in development targeting protein synthesis.2-Deoxystreptamine-containing aminoglycoside antibiotics: recent advances in the characterization and manipulation of their biosynthetic pathways.Natural product and natural product derived drugs in clinical trials.Multidrug-resistant Gram-negative bacteria in solid organ transplant recipients with bacteremias.Recent developments in antibiotic agents for the treatment of complicated intra-abdominal infections.Parallel pathways in the biosynthesis of aminoglycoside antibiotics.Investigational drugs in phase I and phase II clincial trials for the treatment of hospital-acquired pneumonia.Aminoglycosides: An Overview.The antibiotic pipeline for multi-drug resistant gram negative bacteria: what can we expect?Recent Advances in the Rational Design and Optimization of Antibacterial Agents.

P2860

Q21131125-897FD115-FF92-45B2-A751-0E1EDF7CA675 Q26765868-EA4CDFA9-FED2-4F7F-826D-DDE60D753FDC Q26859978-DFE3050B-C474-4996-87B7-0B5ED5887965 Q27681495-8F833977-C10E-4ECF-98FA-60A19A683DF4 Q28246841-B4F2D0F5-FACF-475C-9FCA-DBFCC417C31F Q30249262-D5D6AB9C-9B19-42D2-9F7D-C6EB43EFD66A Q33941796-1C643A70-A385-4A54-8FE2-6FE05784A47B Q33951177-746DEFF5-668F-4559-B365-23C72887090C Q34058006-216AA49D-C91C-4CB8-8F5B-6EBDC14FFD61 Q34269044-F23BEB0A-CB15-478B-9FFE-80DA59CEC146 Q34334742-3F967729-FDD6-45DF-9646-BC2D1231A93F Q34375204-7DF33E95-29BB-469F-B990-80B186972E2F Q34427652-B0B08E2B-F811-4384-910D-D8EA6081A665 Q34596853-546BA47B-3D00-4E08-8EFE-6F9FCF841B14 Q34632230-431C908B-20DE-4870-84A9-E9F4289B1227 Q34673393-6BEDC729-314D-4EE8-8D98-4E28EA29FC2A Q35482558-DE7406E3-B595-4AFF-A638-A5BAC410E20E Q35607775-31DFEC4C-0107-4C41-BEB3-397E48007015 Q36107990-918CCDF7-F6D5-4B53-BBAC-62280E0BFC0E Q36281015-89F80900-4916-47B0-B0E9-81B6FC22E6DE Q36396224-701A100E-604C-4FED-9143-62E6FB76A149 Q36575916-7B9DC0CB-86BA-47DE-8940-263BB3F2509F Q36726249-6D44501A-8AC0-4B73-B7A5-4563AC76A40D Q37123987-7543E9D4-C5BD-4EDE-9E87-89B9E5A40DB2 Q37528001-6E22F16B-E1B9-47ED-97FB-562072EEB2C4 Q37712980-B4D8C520-54D2-48C8-97B9-9E70CB8EFDF5 Q37839231-30D75D3A-CD4E-4F96-B7CB-ECD809D261FA Q37879199-F4A761C2-3D3F-47C7-AA1E-4B7E18C1F419 Q37937558-17F5A3BC-4DB6-457D-8120-9B92868AA7FC Q37956403-381B286F-BF21-46A6-8E62-9DB5FF7A2385 Q37970724-AD3C49A7-8066-4D2D-9965-518952D438DE Q38062339-29DF802C-55C8-49B0-86A6-6453B5331677 Q38247457-12144A1E-4324-4BCE-9039-1000F7C3CF7A Q38267323-27EE629A-B450-4BE1-970D-8571AB4A90E4 Q38648594-A0CD03C0-0783-4ED5-A6A2-522BFEA21E37 Q38670416-BE9D3F36-F8FE-4240-9028-B2D52D747058 Q38783043-D35AC4EA-66E4-49A0-B886-220DCCAF431E Q38851189-053CD0FF-B64F-4FB5-B709-B14207B82DDF Q38892589-830797AB-5C4E-465F-9503-47CCF108824E Q38958278-C79D998E-2432-491C-8035-7153A6D9AEF0

P2860

Synthesis and spectrum of the neoglycoside ACHN-490

http://www.wikidata.org/entity/Q34134992

description

2010 nî lūn-bûn

@nan

2010 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի օգոստոսին հրատարակված գիտական հոդված

@hy

2010年の論文

@ja

2010年論文

@yue

2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

name

Synthesis and spectrum of the neoglycoside ACHN-490

@ast

Synthesis and spectrum of the neoglycoside ACHN-490

@en

Synthesis and spectrum of the neoglycoside ACHN-490

@nl

type

label

Synthesis and spectrum of the neoglycoside ACHN-490

@ast

Synthesis and spectrum of the neoglycoside ACHN-490

@en

Synthesis and spectrum of the neoglycoside ACHN-490

@nl

prefLabel

Synthesis and spectrum of the neoglycoside ACHN-490

@ast

Synthesis and spectrum of the neoglycoside ACHN-490

@en

Synthesis and spectrum of the neoglycoside ACHN-490

@nl

P1433

Q34134992-328F93A7-EE55-4FD0-933D-E7A2741A63F5

P1476

Q34134992-A1CBE9E8-35A5-420D-AA19-DFFB733738C4

P2093

Q34134992-1BC16344-1F29-4784-B81B-9E28BD1FED86

Q34134992-287C9A7B-4B21-4AA3-9B1A-481C8BDD3196

Q34134992-2E2942E3-B0A9-410D-ABF0-7278FA5E9A87

Q34134992-3BA7549F-733A-482F-ABE7-E652D5ED196A

Q34134992-41FA54AE-886D-4771-8743-AC4902A87E83

Q34134992-4F22910E-B78E-4EFF-85CA-6C77B7FE469E

Q34134992-70B91396-0C25-4A4D-ACB4-D82CA4EA9624

Q34134992-7354889D-7AB9-43E1-8CE1-D2C25894C06F

Q34134992-7ADBFE13-DE18-4B2B-81F5-63E5AB7AB8EE

Q34134992-81F7DD3E-11A0-4D22-84DC-991245202B0D

P2860

Q34134992-128254F2-19B1-4A58-A13F-09F09BCFE3DD

Q34134992-1E9EB751-A721-44DA-BF1E-39F78AEB3A16

Q34134992-2C8C177F-0CBD-4A63-A446-19B4456169AE

Q34134992-45FA7C0E-345D-4966-AEB0-5478F8B4EC62

Q34134992-5DCE3F95-6282-4D48-8F94-D9809C8D05B5

Q34134992-736E30D4-4D55-4368-80B1-F92703AF0783

Q34134992-755AE6B7-D061-49FB-84DF-BE4AE5465F4A

Q34134992-77E1A235-B699-4BDD-A35A-0FCA6B878BCD

Q34134992-968C657B-2F78-4C51-800F-96FD79A2274A

Q34134992-A81499C6-6AA5-4671-8E89-4DEA9966A926

P304

Q34134992-8D0984FA-4AEF-4E56-A864-C53AD2E41458

P31

Q34134992-9B808A68-40EC-4951-A2D5-D83D907E3148

P356

Q34134992-835B6F25-E0D3-4D74-88F2-03EC5489C0E1

P407

Q34134992-767F1114-6A22-49D6-8B7B-C8233F8D219F

P433

Q34134992-E4F884B6-767A-40A0-80E7-89C8BE3E4A75

P478

Q34134992-93B8B2B6-B50E-46A5-A2CB-F19766882609

P577

Q34134992-A9734105-26E2-4727-8ECC-7DAA29F911F3

P698

Q34134992-540881D3-E892-42A0-9BC7-7B059EEDBE78

P932

Q34134992-C927492F-AEF4-44E5-8E06-9F5333DE8184

P356

P1433

Antimicrobial Agents and Chemotherapy

P1476

Synthesis and spectrum of the neoglycoside ACHN-490

@en

P2093

Adam A Goldblum

http://www.w3.org/2001/XMLSchema#string

Aya Kubo

http://www.w3.org/2001/XMLSchema#string

Darin J Hildebrandt

http://www.w3.org/2001/XMLSchema#string

Eliana S Armstrong

http://www.w3.org/2001/XMLSchema#string

George H Miller

http://www.w3.org/2001/XMLSchema#string

Heinz E Moser

http://www.w3.org/2001/XMLSchema#string

James B Aggen

http://www.w3.org/2001/XMLSchema#string

Kenneth B Wlasichuk

http://www.w3.org/2001/XMLSchema#string

Lee Ann Feeney

http://www.w3.org/2001/XMLSchema#string

Marcela Gomez

http://www.w3.org/2001/XMLSchema#string

P2860

Aminoglycoside-modifying enzymes.

16S ribosomal RNA methylation: emerging resistance mechanism against aminoglycosides.

The changing epidemiology of resistance.

Molecular understanding of aminoglycoside action and resistance.

Aminoglycoside antibiotics: old drugs and new therapeutic approaches.

Back to the future: using aminoglycosides again and how to dose them optimally.

Molecular genetics of aminoglycoside resistance genes and familial relationships of the aminoglycoside-modifying enzymes.

Contribution of the MexXY multidrug transporter to aminoglycoside resistance in Pseudomonas aeruginosa clinical isolates.

Chemotherapeutic evaluation of 5-episisomicin (Sch 22591), a new semisynthetic aminoglycoside.

Clinical significance of in vitro synergism between antibiotics in gram-negative infections.

P304

4636-4642

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1128/AAC.00572-10

http://www.w3.org/2001/XMLSchema#string

P407

P433

11

http://www.w3.org/2001/XMLSchema#string

P478

54

http://www.w3.org/2001/XMLSchema#string

P577

2010-08-30T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

20805391

http://www.w3.org/2001/XMLSchema#string

P932

2976124

http://www.w3.org/2001/XMLSchema#string