Altered distributions of Gemini of coiled bodies and mitochondria in motor neurons of TDP-43 transgenic mice.
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VAPB interacts with the mitochondrial protein PTPIP51 to regulate calcium homeostasisFrom animal models to human disease: a genetic approach for personalized medicine in ALSTransporting mitochondria in neuronsCopy Number Variations in the Survival Motor Neuron Genes: Implications for Spinal Muscular Atrophy and Other Neurodegenerative DiseasesDysregulated axonal RNA translation in amyotrophic lateral sclerosisImpaired Autophagy and Defective Mitochondrial Function: Converging Paths on the Road to Motor Neuron DegenerationALS Patient Stem Cells for Unveiling Disease Signatures of Motoneuron Susceptibility: Perspectives on the Deadly Mitochondria, ER Stress and Calcium TriadMouse models of frontotemporal dementiaConverging mechanisms in ALS and FTD: disrupted RNA and protein homeostasisMitochondrial dysfunction in amyotrophic lateral sclerosis - a valid pharmacological target?The role of transposable elements in health and diseases of the central nervous systemOxidative stress and mitochondrial damage: importance in non-SOD1 ALSDoes a loss of TDP-43 function cause neurodegeneration?Mitochondrial transport in neurons: impact on synaptic homeostasis and neurodegeneration.RNA-processing protein TDP-43 regulates FOXO-dependent protein quality control in stress responseFUS Interacts with HSP60 to Promote Mitochondrial DamageNon-human primate model of amyotrophic lateral sclerosis with cytoplasmic mislocalization of TDP-43Axonal transport deficits and degeneration can evolve independently in mouse models of amyotrophic lateral sclerosis.Overexpression of human wild-type FUS causes progressive motor neuron degeneration in an age- and dose-dependent fashion.ALS-linked TDP-43 mutations produce aberrant RNA splicing and adult-onset motor neuron disease without aggregation or loss of nuclear TDP-43.Overexpression of ALS-associated p.M337V human TDP-43 in mice worsens disease features compared to wild-type human TDP-43 mice.Abnormal mitochondrial transport and morphology are common pathological denominators in SOD1 and TDP43 ALS mouse models.Expression of ALS-linked TDP-43 mutant in astrocytes causes non-cell-autonomous motor neuron death in ratsPrevention of intestinal obstruction reveals progressive neurodegeneration in mutant TDP-43 (A315T) mice.Wild type human TDP-43 potentiates ALS-linked mutant TDP-43 driven progressive motor and cortical neuron degeneration with pathological features of ALS.Astrocytic TDP-43 pathology in Alexander diseaseMutant TDP-43 does not impair mitochondrial bioenergetics in vitro and in vivoQuantitative analysis of cryptic splicing associated with TDP-43 depletion.Drosophila lines with mutant and wild type human TDP-43 replacing the endogenous gene reveals phosphorylation and ubiquitination in mutant lines in the absence of viability or lifespan defects.Nuclear TAR DNA-binding protein 43: A new target for amyotrophic lateral sclerosis treatmentSelective pattern of motor system damage in gamma-synuclein transgenic mice mirrors the respective pathology in amyotrophic lateral sclerosis.Presynaptic localization of Smn and hnRNP R in axon terminals of embryonic and postnatal mouse motoneuronsTransposable elements in TDP-43-mediated neurodegenerative disorders.TDP-43 potentiates alpha-synuclein toxicity to dopaminergic neurons in transgenic miceTDP-43 neurotoxicity and protein aggregation modulated by heat shock factor and insulin/IGF-1 signalingThe pathological phenotypes of human TDP-43 transgenic mouse models are independent of downregulation of mouse Tdp-43Motor neuron trophic factors: therapeutic use in ALS?ALS-causative mutations in FUS/TLS confer gain and loss of function by altered association with SMN and U1-snRNP.A network of RNA and protein interactions in Fronto Temporal Dementia.Nuclear localization of SMN and FUS is not altered in fibroblasts from patients with sporadic ALS
P2860
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P2860
Altered distributions of Gemini of coiled bodies and mitochondria in motor neurons of TDP-43 transgenic mice.
description
2010 nî lūn-bûn
@nan
2010 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Altered distributions of Gemin ...... ons of TDP-43 transgenic mice.
@ast
Altered distributions of Gemin ...... ons of TDP-43 transgenic mice.
@en
Altered distributions of Gemin ...... ons of TDP-43 transgenic mice.
@nl
type
label
Altered distributions of Gemin ...... ons of TDP-43 transgenic mice.
@ast
Altered distributions of Gemin ...... ons of TDP-43 transgenic mice.
@en
Altered distributions of Gemin ...... ons of TDP-43 transgenic mice.
@nl
prefLabel
Altered distributions of Gemin ...... ons of TDP-43 transgenic mice.
@ast
Altered distributions of Gemin ...... ons of TDP-43 transgenic mice.
@en
Altered distributions of Gemin ...... ons of TDP-43 transgenic mice.
@nl
P2093
P2860
P356
P1476
Altered distributions of Gemin ...... rons of TDP-43 transgenic mice
@en
P2093
Donald L Price
Philip C Wong
P2860
P304
16325-16330
P356
10.1073/PNAS.1003459107
P407
P577
2010-08-24T00:00:00Z