Allosteric binding sites on cell-surface receptors: novel targets for drug discovery.
about
Flexible modulation of agonist efficacy at the human A3 adenosine receptor by the imidazoquinoline allosteric enhancer LUF6000Toward selective drug development for the human 5-hydroxytryptamine 1E receptor: a comparison of 5-hydroxytryptamine 1E and 1F receptor structure-affinity relationshipsStructural basis for extracellular interactions between calcitonin receptor-like receptor and receptor activity-modifying protein 2 for adrenomedullin-specific bindingTherapeutic potential for novel drugs targeting the type 1 cholecystokinin receptorHeteromerization of G protein-coupled receptors: relevance to neurological disorders and neurotherapeutics.The ANG-(1-7)/ACE2/mas axis in the regulation of nephron functionNootropic alpha7 nicotinic receptor allosteric modulator derived from GABAA receptor modulatorsSmall-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonistsCross genome phylogenetic analysis of human and Drosophila G protein-coupled receptors: application to functional annotation of orphan receptors.Allosteric Modulation of Chemoattractant ReceptorsThe Camerino symposium series (1978-2013): a privileged observatory of receptorology developmentRegulation of G protein-coupled receptors by allosteric ligandsDREADDs: novel tools for drug discovery and developmentExploring the role of receptor flexibility in structure-based drug discoveryDrugs for allosteric sites on receptorsNon-traditional roles of G protein-coupled receptors in basic cell biologyThe GABA(B) receptor positive modulator BHF177 attenuated anxiety, but not conditioned fear, in rats.Molecular Mechanism of Flop Selectivity and Subsite Recognition for an AMPA Receptor Allosteric Modulator: Structures of GluA2 and GluA3 in Complexes with PEPAMetalloproteases Affecting Blood Coagulation, Fibrinolysis and Platelet Aggregation from Snake Venoms: Definition and Nomenclature of Interaction SitesNovel Allosteric Modulators of G Protein-coupled ReceptorsA new mechanism of allostery in a G protein-coupled receptor dimerEstimating the threshold surface density of Gp120-CCR5 complexes necessary for HIV-1 envelope-mediated cell-cell fusionEffects of the dopamine D2 allosteric modulator, PAOPA, on the expression of GRK2, arrestin-3, ERK1/2, and on receptor internalizationA unified view of "how allostery works"Chemical, target, and bioactive properties of allosteric modulationProperties of protein drug target classesVibrational resonance, allostery, and activation in rhodopsin-like G protein-coupled receptors.Effects of the allosteric modulator SCH-202676 on adenosine and P2Y receptors.Evaluating the role of the alpha-7 nicotinic acetylcholine receptor in the pathophysiology and treatment of schizophrenia.The allosteric enhancer PD81,723 increases chimaeric A1/A2A adenosine receptor coupling with GsCoupling sequence-specific recognition to DNA modification.Loss of object recognition memory produced by extended access to methamphetamine self-administration is reversed by positive allosteric modulation of metabotropic glutamate receptor 5Comparison of the effects of the GABAB receptor positive modulator BHF177 and the GABAB receptor agonist baclofen on anxiety-like behavior, learning, and memory in miceIdentification and quantification of a new family of peptide endocannabinoids (Pepcans) showing negative allosteric modulation at CB1 receptors.Discovery and characterization of orthosteric and allosteric muscarinic M2 acetylcholine receptor ligands by affinity selection-mass spectrometry.Mapping of allosteric druggable sites in activation-associated conformers of the M2 muscarinic receptorAccelerated molecular dynamics simulations of ligand binding to a muscarinic G-protein-coupled receptor.Neuroprotection by selective allosteric potentiators of the EP2 prostaglandin receptor.Discovery of a Negative Allosteric Modulator of GABAB ReceptorsSeven transmembrane receptors as shapeshifting proteins: the impact of allosteric modulation and functional selectivity on new drug discovery.
P2860
Q21262008-E802A80A-521E-4F99-884A-237AE7C870C0Q24297642-864C8C9C-9B55-404C-BD6A-BBA2A4814307Q24298039-D6CCAD34-F7C5-4C64-845F-6E705F680CD3Q24628602-8122BE2C-3854-43CA-A97E-3E00AAADD007Q24630645-700F3468-FA48-411C-9FE8-860A48F9111AQ24633556-AB0B2C94-5555-4424-ADF7-84E485B22DE2Q24681828-521F443D-9DE9-4C98-B39A-3DF5C25529C6Q24794838-0EFA36B0-B3DE-437D-9443-D81EB014649DQ24816080-DD5E9BF7-C0F2-4425-85FC-232640349D2EQ26747395-0C00A75A-AA3A-4641-AFF7-C5C88BC4A2EBQ26830483-AB8A768E-D2DE-416E-B1D8-F51CFD4E0625Q26864384-3044DA02-BBB0-443D-AE08-D7A0665B9EEAQ26995396-1162C303-E355-43C6-ADD2-943884C0BAEAQ27001129-FAFF62E0-5E04-437F-AE5B-B9A37F5C1DECQ27006721-026AAFFE-4333-4626-9D18-3816E57610FFQ27006799-8DC09A4A-11DE-46B8-94E5-1AFFDEFB55F9Q27305120-6CC933F5-B1B3-48C6-BB0B-617F9968CC62Q27660095-F3E47A9A-047F-4ADD-B55F-9AE5E3743732Q28075348-43A1017E-85DE-437F-945A-1DBF89B0D866Q28081112-F5EE321F-5A36-4DCD-AC7A-EAFC3525BA1EQ28245604-CB9BD1EF-FA73-449F-BE37-D0357D34DDB1Q28478341-A077590E-3BA5-4542-86A5-735A7D8C339FQ28535151-51905445-CA01-40F7-8873-2D7B12573989Q28539606-68824465-E4A1-46E6-B93D-853B5906ECCDQ28541837-00151205-4976-45F0-8AE8-DFA0DF8A68EAQ28545197-7969A51E-655E-4412-853E-8EF998CC3D0BQ30395265-6C0B87F3-D453-4DF4-9D92-4A07128EC994Q30407404-6022A0F6-ACB1-4F65-8520-B74EE809901CQ30428422-0CCA571B-3E9E-4ABE-AECB-E41968BC2A87Q30439117-861F4ADC-E310-479D-88BE-BF9E2DB1D969Q30490702-3E9B6D51-B3F4-4B5C-8BFB-AB1B402C9A41Q30498430-FF08A478-A838-4FF5-A963-290271C42CD3Q30539539-75B83D35-A8CB-495C-BB3E-E8F53560158BQ30561814-B3109885-7A6E-4C5A-9C75-7A5A6B9AAFB8Q33234391-D01421AC-EDBC-4FA4-8C6B-995446F9B314Q33577530-18B4F810-DCBB-46CA-82CE-D99B8242B02DQ33699049-6BE19F1C-C320-4EE8-A27A-8EF53FC5CA65Q33719741-E4BCD52C-FBF0-4E79-A164-808859A78EB8Q33889093-E65B0E3D-475B-40F6-81DF-2F3E4758EDD6Q33890786-9A455ADB-11B3-4476-BF46-2C2F45135E84
P2860
Allosteric binding sites on cell-surface receptors: novel targets for drug discovery.
description
2002 nî lūn-bûn
@nan
2002 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի մարտին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Allosteric binding sites on cell-surface receptors: novel targets for drug discovery.
@ast
Allosteric binding sites on cell-surface receptors: novel targets for drug discovery.
@en
Allosteric binding sites on cell-surface receptors: novel targets for drug discovery.
@nl
type
label
Allosteric binding sites on cell-surface receptors: novel targets for drug discovery.
@ast
Allosteric binding sites on cell-surface receptors: novel targets for drug discovery.
@en
Allosteric binding sites on cell-surface receptors: novel targets for drug discovery.
@nl
prefLabel
Allosteric binding sites on cell-surface receptors: novel targets for drug discovery.
@ast
Allosteric binding sites on cell-surface receptors: novel targets for drug discovery.
@en
Allosteric binding sites on cell-surface receptors: novel targets for drug discovery.
@nl
P356
P1476
Allosteric binding sites on cell-surface receptors: novel targets for drug discovery.
@en
P2093
Arthur Christopoulos
P2888
P304
P356
10.1038/NRD746
P577
2002-03-01T00:00:00Z