The Bmi-1 oncogene induces telomerase activity and immortalizes human mammary epithelial cells.
about
Immortalization of human mammary epithelial cells is associated with inactivation of the p14ARF-p53 pathwayIdentification of a polymorphism in the RING finger of human Bmi-1 that causes its degradation by the ubiquitin-proteasome systemPTEN inhibits BMI1 function independently of its phosphatase activityMicroarray analysis identifies a death-from-cancer signature predicting therapy failure in patients with multiple types of cancerMammary stem cells, self-renewal pathways, and carcinogenesisBmi-1 promotes neural stem cell self-renewal and neural development but not mouse growth and survival by repressing the p16Ink4a and p19Arf senescence pathways.Control of the replicative life span of human fibroblasts by p16 and the polycomb protein Bmi-1Bmi1, stem cells, and senescence regulationThe NRIF3 family of transcriptional coregulators induces rapid and profound apoptosis in breast cancer cellsMiR-15a and MiR-16 control Bmi-1 expression in ovarian cancerBMI1 is recruited to DNA breaks and contributes to DNA damage-induced H2A ubiquitination and repairMel-18 acts as a tumor suppressor by repressing Bmi-1 expression and down-regulating Akt activity in breast cancer cellsContribution of polycomb homologues Bmi-1 and Mel-18 to medulloblastoma pathogenesisMel-18, a polycomb group protein, regulates cell proliferation and senescence via transcriptional repression of Bmi-1 and c-Myc oncoproteinsMammary epithelial cell transformation: insights from cell culture and mouse models.Cancer-Specific Telomerase Reverse Transcriptase (TERT) Promoter Mutations: Biological and Clinical ImplicationsTWIST1 and BMI1 in Cancer Metastasis and ChemoresistanceYin Yang 1 is associated with cancer stem cell transcription factors (SOX2, OCT4, BMI1) and clinical implicationA Novel Aspect of Tumorigenesis-BMI1 Functions in Regulating DNA Damage ResponseTargeting self-renewal pathways in cancer stem cells: clinical implications for cancer therapymiRNAs in breast cancer tumorigenesis (Review)Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cellsSwitches, excitable responses and oscillations in the Ring1B/Bmi1 ubiquitination systemGlobal gene profiling of spontaneous hepatocellular carcinoma in B6C3F1 mice: similarities in the molecular landscape with human liver cancerPrognostic relevance of Bmi-1 expression and autoantibodies in esophageal squamous cell carcinoma.Overexpression of BMI-1 promotes cell growth and resistance to cisplatin treatment in osteosarcoma.HPV16 E7 protein and hTERT proteins defective for telomere maintenance cooperate to immortalize human keratinocytesExpression of Bmi-1 is a prognostic marker in bladder cancerExpression of aldehyde dehydrogenase 1 (ALDH1) is associated with basal-like markers and features of aggressive tumours in African breast cancer.Intestinal stem cells and their roles during mucosal injury and repair.The Bmi-1 polycomb protein antagonizes the (-)-epigallocatechin-3-gallate-dependent suppression of skin cancer cell survival.Bmi-1 expression predicts prognosis in squamous cell carcinoma of the tongue.BMI1 and Mel-18 oppositely regulate carcinogenesis and progression of gastric cancer.Expression of BMI-1 and Mel-18 in breast tissue--a diagnostic marker in patients with breast cancerCombination of hTERT and bmi-1, E6, or E7 induces prolongation of the life span of bone marrow stromal cells from an elderly donor without affecting their neurogenic potential.Downregulation of Bmi1 in breast cancer stem cells suppresses tumor growth and proliferation.Deletion analysis of BMI1 oncoprotein identifies its negative regulatory domainTelomerase-immortalized human mammary stem/progenitor cells with ability to self-renew and differentiateChromatin remodeling in mammary gland differentiation and breast tumorigenesis.Oncogenic role of the chromobox protein CBX7 in gastric cancer.
P2860
Q24308746-0272D6DF-4F5A-4E82-8760-7C06F5F4AB04Q24313030-EDE06886-D80D-415D-AF0E-4B21346B378BQ24315949-C5C8BB44-9B71-445A-A487-C2B7251160EBQ24528253-63489830-6C5E-41DC-B123-311EC9FE323DQ24529145-682A7428-409D-4AD1-BE10-1A80B669942EQ24529593-2A4DE60E-D584-4B8B-A619-5A2F39D68045Q24540711-D5CDC1F8-5B39-43BE-868F-AC348805A0C3Q24614474-3D3AEEE3-4F44-4465-A1AF-785EFD5A9CABQ24623349-CBA964E2-BCD2-4CB6-A468-23A761ABDEB9Q24632636-01060A23-E9D2-410C-800A-1DE36758892BQ24634217-9A88B15C-C6C8-4C34-9F65-EBF022EF7703Q24654211-639E68B0-458C-4EFD-9B88-647A8BC2C60CQ24675945-4257B521-E2F6-4B30-9757-BD3DC5E819CEQ24681882-847BD6E7-BEEC-4D12-A911-D5625A2306B2Q24810846-37403476-802C-4C62-A362-BA6B7F84F01FQ26738705-5E208418-DEEC-48EF-9CD6-4AF8B83D5C10Q26744196-C80FDA6A-BF44-4883-B1F6-B6C688C198D4Q26745972-86F7287D-BF9F-4A3C-961C-3B0419DADE73Q26774980-C8D3B754-EF14-426F-9DE6-C0C59DF7AB45Q26775961-1EA319CC-3FFB-49B2-839A-A12CCB8A662EQ26824561-F64F9F44-4301-4522-B83A-30E49AF0127BQ28246460-D98BCE45-3877-4811-B120-B0D7922004A0Q28478440-3DEFDF0C-4FE1-4049-827F-F6A20BD2DA16Q28829385-F0CE06CF-AE5A-48BA-98E3-0CFDF9878209Q30988759-6B48B9F9-B54F-4DCB-A04A-FF3D96699F36Q30999677-8663DE75-806B-4E12-8078-4EE7364E586DQ31115332-9C123C93-603A-40C9-A04A-550E580924F4Q33410666-1B43684B-D601-4BD6-A695-AD796674EDAAQ33630849-5DBCEC0B-F99C-4C36-A49E-F59DE814F5D5Q33692786-B5CCDB19-C778-43C3-99A0-69DDCD4733F9Q33705252-6D4EE50D-A545-4C52-A18D-EA3B736763B6Q33708108-52824DF3-9E38-44F9-8C5C-11F88BBB6263Q33741646-B89C1547-169E-4200-A117-91E0644F183DQ33772874-8FCC9980-D56C-4440-AF46-DB67FC7CC532Q33836823-DB57772E-493D-4976-A797-4C813D3282ACQ33888935-D85E7D07-982F-4D04-BC13-519B173A083DQ33975692-95736D2C-0CDE-41EE-9AF9-244A9A03FB07Q34069482-B4097D71-954F-43D5-8C8D-A374703AE49CQ34080232-25E7A074-29A6-4642-9EF7-8FB85F26A8EDQ34105084-717DD77D-18E0-4412-A29A-55C82666FE0A
P2860
The Bmi-1 oncogene induces telomerase activity and immortalizes human mammary epithelial cells.
description
2002 nî lūn-bûn
@nan
2002 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
The Bmi-1 oncogene induces tel ...... uman mammary epithelial cells.
@ast
The Bmi-1 oncogene induces tel ...... uman mammary epithelial cells.
@en
The Bmi-1 oncogene induces tel ...... uman mammary epithelial cells.
@nl
type
label
The Bmi-1 oncogene induces tel ...... uman mammary epithelial cells.
@ast
The Bmi-1 oncogene induces tel ...... uman mammary epithelial cells.
@en
The Bmi-1 oncogene induces tel ...... uman mammary epithelial cells.
@nl
prefLabel
The Bmi-1 oncogene induces tel ...... uman mammary epithelial cells.
@ast
The Bmi-1 oncogene induces tel ...... uman mammary epithelial cells.
@en
The Bmi-1 oncogene induces tel ...... uman mammary epithelial cells.
@nl
P2093
P1433
P1476
The Bmi-1 oncogene induces tel ...... uman mammary epithelial cells.
@en
P2093
David E Wazer
Goberdhan P Dimri
Jacqueline J L Jacobs
Jose-Luis Martinez
Judith Campisi
Koji Itahana
Maarten Van Lohuizen
Petra Keblusek
Vimla Band
P304
P407
P577
2002-08-01T00:00:00Z