NMDA-mediated Ca(2+) influx drives aberrant ryanodine receptor activation in dendrites of young Alzheimer's disease mice. - Wikidata - wikimedia - TriplyDB

NMDA-mediated Ca(2+) influx drives aberrant ryanodine receptor activation in dendrites of young Alzheimer's disease mice.

NMDA-mediated Ca(2+) influx drives aberrant ryanodine receptor activation in dendrites of young Alzheimer's disease mice.

http://www.wikidata.org/entity/Q34149384

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Role of presenilin 1 in structural plasticity of cortical dendritic spines in vivo FK506-binding protein 1b/12.6: a key to aging-related hippocampal Ca2+ dysregulation?Spines, plasticity, and cognition in Alzheimer's model mice Ryanodine Receptor Activation Induces Long-Term Plasticity of Spine Calcium Dynamics An X-linked channelopathy with cardiomegaly due to a CLIC2 mutation enhancing ryanodine receptor channel activity.Hippocampal Gαq/₁₁ but not Gαo-coupled receptors are altered in aging.Reduced synaptic STIM2 expression and impaired store-operated calcium entry cause destabilization of mature spines in mutant presenilin mice.Early calcium dysregulation in Alzheimer's disease: setting the stage for synaptic dysfunction.Withdrawal from cocaine self-administration alters NMDA receptor-mediated Ca2+ entry in nucleus accumbens dendritic spines.Stabilizing ER Ca2+ channel function as an early preventative strategy for Alzheimer's disease.Regulation of dendritic calcium release in striatal spiny projection neurons Endoplasmic reticulum Ca(2+) handling in excitable cells in health and disease Altered ryanodine receptor expression in mild cognitive impairment and Alzheimer's disease.Loss of Spatial Memory, Learning, and Motor Function During Normal Aging Is Accompanied by Changes in Brain Presenilin 1 and 2 Expression Levels.Morin attenuates tau hyperphosphorylation by inhibiting GSK3β.Calcium channel blocking as a therapeutic strategy for Alzheimer's disease: the case for isradipine.Critical role of soluble amyloid-β for early hippocampal hyperactivity in a mouse model of Alzheimer's disease.Early presynaptic and postsynaptic calcium signaling abnormalities mask underlying synaptic depression in presymptomatic Alzheimer's disease mice.Impaired Cholinergic Excitation of Prefrontal Attention Circuitry in the TgCRND8 Model of Alzheimer's Disease Ryanodine receptor blockade reduces amyloid-β load and memory impairments in Tg2576 mouse model of Alzheimer disease.Dysregulation of neural calcium signaling in Alzheimer disease, bipolar disorder and schizophrenia Calcium signaling, excitability, and synaptic plasticity defects in a mouse model of Alzheimer's disease β amyloid peptide plaques fail to alter evoked neuronal calcium signals in APP/PS1 Alzheimer's disease mice Role of endoplasmic reticulum Ca2+ signaling in the pathogenesis of Alzheimer disease The therapeutic potential of small-conductance KCa2 channels in neurodegenerative and psychiatric diseases Presenilins regulate the cellular activity of ryanodine receptors differentially through isotype-specific N-terminal cysteines.L-type Ca2+ currents at CA1 synapses, but not CA3 or dentate granule neuron synapses, are increased in 3xTgAD mice in an age-dependent manner.Cocaine increases ryanodine receptors via dopamine D1 receptors.Presenilins function in ER calcium leak and Alzheimer's disease pathogenesis.Ca2+ dysfunction in neurodegenerative disorders: Alzheimer's disease.Presenilins as endoplasmic reticulum calcium leak channels and Alzheimer's disease pathogenesis.Consequences of inhibiting amyloid precursor protein processing enzymes on synaptic function and plasticity.Calcium dysregulation and neuroinflammation: discrete and integrated mechanisms for age-related synaptic dysfunction.Glutamate drugs and pharmacogenetics of OCD: a pathway-based exploratory approach.Ryanodine receptors: physiological function and deregulation in Alzheimer disease.Chronic neuroinflammation in Alzheimer's disease: new perspectives on animal models and promising candidate drugs.Dantrolene, a treatment for Alzheimer disease?Presenilin1/γ-secretase protects neurons from glucose deprivation-induced death by regulating miR-212 and PEA15.The Role of Reelin Signaling in Alzheimer's Disease.Post-translational remodeling of ryanodine receptor induces calcium leak leading to Alzheimer's disease-like pathologies and cognitive deficits.

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NMDA-mediated Ca(2+) influx drives aberrant ryanodine receptor activation in dendrites of young Alzheimer's disease mice.

http://www.wikidata.org/entity/Q34149384

description

2010 nî lūn-bûn

@nan

2010 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

NMDA-mediated Ca

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NMDA-mediated Ca(2+) influx dr ...... oung Alzheimer's disease mice.

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NMDA-mediated Ca(2+) influx dr ...... oung Alzheimer's disease mice.

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type

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NMDA-mediated Ca

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NMDA-mediated Ca(2+) influx dr ...... oung Alzheimer's disease mice.

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NMDA-mediated Ca(2+) influx dr ...... oung Alzheimer's disease mice.

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NMDA-mediated Ca

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NMDA-mediated Ca(2+) influx dr ...... oung Alzheimer's disease mice.

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NMDA-mediated Ca(2+) influx dr ...... oung Alzheimer's disease mice.

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JNEUROSCI.2474-10.2010

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Journal of Neuroscience

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NMDA-mediated Ca(2+) influx dr ...... oung Alzheimer's disease mice.

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Grace E Stutzmann

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Ivan Goussakov

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Megan B Miller

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P2860

Presenilins form ER Ca2+ leak channels, a function disrupted by familial Alzheimer's disease-linked mutations

Familial Alzheimer disease-linked mutations specifically disrupt Ca2+ leak function of presenilin 1

Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

Soluble oligomers of the amyloid beta-protein impair synaptic plasticity and behavior

Presenilins are essential for regulating neurotransmitter release

Effect of dimebon on cognition, activities of daily living, behaviour, and global function in patients with mild-to-moderate Alzheimer's disease: a randomised, double-blind, placebo-controlled study

Calmodulin activation by calcium transients in the postsynaptic density of dendritic spines

Formation of molecular complexes by N-methyl-D-aspartate receptor subunit NR2B and ryanodine receptor 2 in neonatal rat myocard

Inositol 1,4,5 trisphosphate receptor and chromogranin B are concentrated in different regions of the hippocampus

Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway

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10.1523/JNEUROSCI.2474-10.2010

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Alzheimer's disease

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