Trop2 expression contributes to tumor pathogenesis by activating the ERK MAPK pathway.
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Trop2 and its overexpression in cancers: regulation and clinical/therapeutic implicationsChemotherapy-induced monoamine oxidase expression in prostate carcinoma functions as a cytoprotective resistance enzyme and associates with clinical outcomesRegulated proteolysis of Trop2 drives epithelial hyperplasia and stem cell self-renewal via β-catenin signalingTROP2 expressed in the trunk of the ureteric duct regulates branching morphogenesis during kidney developmentAntibody discovery ex vivo accelerated by the LacO/LacI regulatory networkIdentification of novel targets for breast cancer by exploring gene switches on a genome scale.Hepatitis C virus network based classification of hepatocellular cirrhosis and carcinomaTrop-2 protein overexpression is an independent marker for predicting disease recurrence in endometrioid endometrial carcinoma.Loss of Trop2 causes ErbB3 activation through a neuregulin-1-dependent mechanism in the mesenchymal subtype of HNSCC.Loss of miR-125b-1 contributes to head and neck cancer development by dysregulating TACSTD2 and MAPK pathway.A novel human Fab antibody for Trop2 inhibits breast cancer growth in vitro and in vivo.Overexpression of TROP2 predicts poor prognosis of patients with cervical cancer and promotes the proliferation and invasion of cervical cancer cells by regulating ERK signaling pathway.A predicted protein, KIAA0247, is a cell cycle modulator in colorectal cancer cells under 5-FU treatmentCervical carcinomas overexpress human trophoblast cell-surface marker (Trop-2) and are highly sensitive to immunotherapy with hRS7, a humanized monoclonal anti-Trop-2 antibody.Uterine and ovarian carcinosarcomas overexpressing Trop-2 are sensitive to hRS7, a humanized anti-Trop-2 antibody.Loss of Trop2 promotes carcinogenesis and features of epithelial to mesenchymal transition in squamous cell carcinoma.Postnatal growth and DNA methylation are associated with differential gene expression of the TACSTD2 gene and childhood fat mass.Significance of EpCAM and TROP2 expression in non-small cell lung cancer.Transcriptional regulation of gene expression during osmotic stress responses by the mammalian target of rapamycin.TROP2 is epigenetically inactivated and modulates IGF-1R signalling in lung adenocarcinoma.Proteomic analysis of acquired tamoxifen resistance in MCF-7 cells reveals expression signatures associated with enhanced migration.Prognostic value of TROP2 in human nasopharyngeal carcinoma.Impact of TROP2 expression on prognosis in solid tumors: A Systematic Review and Meta-analysisIncreased expression of TROP2 in airway basal cells potentially contributes to airway remodeling in chronic obstructive pulmonary disease.Chemotherapy agents-induced immunoresistance in lung cancer cells could be reversed by trop-2 inhibition in vitro and in vivo by interaction with MAPK signaling pathway.Trop2: from development to disease.Molecular targets and pathways involved in liver metastasis of colorectal cancer.Sacituzumab govitecan: an antibody-drug conjugate.Tumor-associated calcium signal transducer 2 regulates neovascularization of non-small-cell lung cancer via activating ERK1/2 signaling pathway.Overexpression of trophoblast cell surface antigen 2 as an independent marker for a poor prognosis and as a potential therapeutic target in epithelial ovarian carcinoma.Expression of Trop2 cell surface glycoprotein in normal and tumor tissues: potential implications as a cancer therapeutic target.Trop2 inhibition suppresses the proliferation and invasion of laryngeal carcinoma cells via the extracellular signal-regulated kinase/mitogen-activated protein kinase pathway.Nano - drug Delivery of Apoptosis Activator 2 to AGS Cells by Liposomes Conjugated with Anti-TROP2 AntibodyTROP2 promotes proliferation, migration and metastasis of gallbladder cancer cells by regulating PI3K/AKT pathway and inducing EMT.Expression of tumor-associated calcium signal transducer 2 in patients with salivary adenoid cystic carcinoma: Correlation with clinicopathological features and prognosis.Expression and clinical significance of the Trop-2 gene in advanced non-small cell lung carcinoma.siRNA targeting of Trop2 suppresses the proliferation and invasion of lung adenocarcinoma H460 cells.Different effects of ERβ and TROP2 expression in Chinese patients with early-stage colon cancer.TROP2 expression and its correlation with tumor proliferation and angiogenesis in human gliomas.Potential therapeutic target and independent prognostic marker of TROP2 in laryngeal squamous cell carcinoma.
P2860
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P2860
Trop2 expression contributes to tumor pathogenesis by activating the ERK MAPK pathway.
description
2010 nî lūn-bûn
@nan
2010 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Trop2 expression contributes to tumor pathogenesis by activating the ERK MAPK pathway.
@ast
Trop2 expression contributes to tumor pathogenesis by activating the ERK MAPK pathway.
@en
Trop2 expression contributes to tumor pathogenesis by activating the ERK MAPK pathway.
@nl
type
label
Trop2 expression contributes to tumor pathogenesis by activating the ERK MAPK pathway.
@ast
Trop2 expression contributes to tumor pathogenesis by activating the ERK MAPK pathway.
@en
Trop2 expression contributes to tumor pathogenesis by activating the ERK MAPK pathway.
@nl
prefLabel
Trop2 expression contributes to tumor pathogenesis by activating the ERK MAPK pathway.
@ast
Trop2 expression contributes to tumor pathogenesis by activating the ERK MAPK pathway.
@en
Trop2 expression contributes to tumor pathogenesis by activating the ERK MAPK pathway.
@nl
P2093
P2860
P356
P1433
P1476
Trop2 expression contributes to tumor pathogenesis by activating the ERK MAPK pathway
@en
P2093
P2860
P2888
P356
10.1186/1476-4598-9-253
P50
P577
2010-09-21T00:00:00Z
P5875
P6179
1005729030