Induction of Noxa sensitizes human colorectal cancer cells expressing Mcl-1 to the small-molecule Bcl-2/Bcl-xL inhibitor, ABT-737.
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Noxa/Bcl-2 protein interactions contribute to bortezomib resistance in human lymphoid cellsTargeting Mcl-1 for the therapy of cancerThe combination of BH3-mimetic ABT-737 with the alkylating agent temozolomide induces strong synergistic killing of melanoma cells independent of p53Upregulating Noxa by ER stress, celastrol exerts synergistic anti-cancer activity in combination with ABT-737 in human hepatocellular carcinoma cellsNanoencapsulation of ABT-737 and camptothecin enhances their clinical potential through synergistic antitumor effects and reduction of systemic toxicity.Celecoxib-induced apoptosis is enhanced by ABT-737 and by inhibition of autophagy in human colorectal cancer cellsThe downregulation of Mcl-1 via USP9X inhibition sensitizes solid tumors to Bcl-xl inhibition.ATR inhibitors VE-821 and VX-970 sensitize cancer cells to topoisomerase i inhibitors by disabling DNA replication initiation and fork elongation responses.Combined inhibition of Notch signaling and Bcl-2/Bcl-xL results in synergistic antimyeloma effect.Simultaneous knock-down of Bcl-xL and Mcl-1 induces apoptosis through Bax activation in pancreatic cancer cellsTherapeutic potential and molecular mechanism of a novel, potent, nonpeptide, Smac mimetic SM-164 in combination with TRAIL for cancer treatmentTargeted inhibition of FAK, PYK2 and BCL-XL synergistically enhances apoptosis in ovarian clear cell carcinoma cell lines.Distribution of Bim determines Mcl-1 dependence or codependence with Bcl-xL/Bcl-2 in Mcl-1-expressing myeloma cells.Differential control of growth, apoptotic activity and gene expression in human colon cancer cells by extracts derived from medicinal herbs, Rhazya stricta and Zingiber officinale and their combinationReversal of Mutant KRAS-Mediated Apoptosis Resistance by Concurrent Noxa/Bik Induction and Bcl-2/Bcl-xL Antagonism in Colon Cancer Cells.Sensitization of BCL-2-expressing breast tumors to chemotherapy by the BH3 mimetic ABT-737NVP-BKM120 potentiates apoptosis in tumor necrosis factor-related apoptosis-inducing ligand-resistant glioma cell lines via upregulation of Noxa and death receptor 5.Radiosensitization by a novel Bcl-2 and Bcl-XL inhibitor S44563 in small-cell lung cancer.The ratio of Mcl-1 and Noxa determines ABT737 resistance in squamous cell carcinoma of the skinpRb/E2F-1-mediated caspase-dependent induction of Noxa amplifies the apoptotic effects of the Bcl-2/Bcl-xL inhibitor ABT-737Apoptotic effect of hot water extract of Sanguisorba officinalis L. in human oral cancer cells.Marizomib, a proteasome inhibitor for all seasons: preclinical profile and a framework for clinical trialsSurvivin inhibitor YM-155 sensitizes tumor necrosis factor- related apoptosis-inducing ligand-resistant glioma cells to apoptosis through Mcl-1 downregulation and by engaging the mitochondrial death pathwayMcl1 downregulation sensitizes neuroblastoma to cytotoxic chemotherapy and small molecule Bcl2-family antagonists.Inhibition of MCL-1 enhances lapatinib toxicity and overcomes lapatinib resistance via BAK-dependent autophagy.Targeting cell death signaling in colorectal cancer: current strategies and future perspectives.Small mitochondria-targeting molecules as anti-cancer agents.Akt inhibition improves irinotecan treatment and prevents cell emergence by switching the senescence response to apoptosis.Molecular mechanism of anticancer effect of Sclerotium rolfsii lectin in HT29 cells involves differential expression of genes associated with multiple signaling pathways: A microarray analysis.Noxa and cancer therapy: Tuning up the mitochondrial death machinery in response to chemotherapy.Antihelminthic benzimidazoles potentiate navitoclax (ABT-263) activity by inducing Noxa-dependent apoptosis in non-small cell lung cancer (NSCLC) cell lines.The small-molecule compound BM-1197 inhibits the antiapoptotic regulators Bcl-2/Bcl-xL and triggers apoptotic cell death in human colorectal cancer cells.Inhibition of NANOG/NANOGP8 downregulates MCL-1 in colorectal cancer cells and enhances the therapeutic efficacy of BH3 mimeticsABT-737 synergizes with arsenic trioxide to induce apoptosis of gastric carcinoma cells in vitro and in vivo.Perturbing pro-survival proteins using quinoxaline derivatives: a structure-activity relationship study.Phosphoinositide 3-kinase/AKT/mTORC1/2 signaling determines sensitivity of Burkitt's lymphoma cells to BH3 mimetics.Methylseleninic acid potentiates multiple types of cancer cells to ABT-737-induced apoptosis by targeting Mcl-1 and Bad.p53-dependent regulation of Mcl-1 contributes to synergistic cell death by ionizing radiation and the Bcl-2/Bcl-XL inhibitor ABT-737.The Bcl-2/Bcl-XL inhibitor ABT-737 promotes death of retinoblastoma cancer cells.Actinomycin D synergistically enhances the efficacy of the BH3 mimetic ABT-737 by downregulating Mcl-1 expression.
P2860
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P2860
Induction of Noxa sensitizes human colorectal cancer cells expressing Mcl-1 to the small-molecule Bcl-2/Bcl-xL inhibitor, ABT-737.
description
2008 nî lūn-bûn
@nan
2008 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Induction of Noxa sensitizes h ...... l-2/Bcl-xL inhibitor, ABT-737.
@ast
Induction of Noxa sensitizes h ...... l-2/Bcl-xL inhibitor, ABT-737.
@en
Induction of Noxa sensitizes h ...... l-2/Bcl-xL inhibitor, ABT-737.
@nl
type
label
Induction of Noxa sensitizes h ...... l-2/Bcl-xL inhibitor, ABT-737.
@ast
Induction of Noxa sensitizes h ...... l-2/Bcl-xL inhibitor, ABT-737.
@en
Induction of Noxa sensitizes h ...... l-2/Bcl-xL inhibitor, ABT-737.
@nl
prefLabel
Induction of Noxa sensitizes h ...... l-2/Bcl-xL inhibitor, ABT-737.
@ast
Induction of Noxa sensitizes h ...... l-2/Bcl-xL inhibitor, ABT-737.
@en
Induction of Noxa sensitizes h ...... l-2/Bcl-xL inhibitor, ABT-737.
@nl
P2093
P2860
P1476
Induction of Noxa sensitizes h ...... l-2/Bcl-xL inhibitor, ABT-737.
@en
P2093
Frank A Sinicrope
Kenji Okumura
Shengbing Huang
P2860
P304
P356
10.1158/1078-0432.CCR-08-1665
P407
P577
2008-12-01T00:00:00Z